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Dkk2 Gene Detail
Summary
  • Symbol
    Dkk2
  • Name
    dickkopf WNT signaling pathway inhibitor 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890663
    NCBI Gene: 56811
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:131791053-131886065 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 61.32 cM, cytoband H2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2868 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890663
 protein coding gene Chr3:131791027-131886065 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027890
 protein coding gene Chr3:134825638-134924768 (+)
A/J MGP_AJ_G0027848
 protein coding gene Chr3:130084795-130180898 (+)
AKR/J MGP_AKRJ_G0027813
 protein coding gene Chr3:133468271-133566166 (+)
BALB/cJ MGP_BALBcJ_G0027861
 protein coding gene Chr3:129915866-130012250 (+)
C3H/HeJ MGP_C3HHeJ_G0027590
 protein coding gene Chr3:133861119-133958427 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028304
 protein coding gene Chr3:139566006-139670578 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025642
 protein coding gene Chr3:125548951-125642883 (+)
CAST/EiJ MGP_CASTEiJ_G0027046
 protein coding gene Chr3:133584297-133693797 (+)
CBA/J MGP_CBAJ_G0027566
 protein coding gene Chr3:144268380-144373073 (+)
DBA/2J MGP_DBA2J_G0027706
 protein coding gene Chr3:129259185-129354761 (+)
FVB/NJ MGP_FVBNJ_G0027673
 protein coding gene Chr3:126834909-126930265 (+)
LP/J MGP_LPJ_G0027816
 protein coding gene Chr3:136299636-136395316 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027704
 protein coding gene Chr3:152185073-152288044 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028362
 protein coding gene Chr3:133138517-133238363 (+)
PWK/PhJ MGP_PWKPhJ_G0026770
 protein coding gene Chr3:129001680-129102210 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026595
 protein coding gene Chr3:131206819-131300891 (+)
WSB/EiJ MGP_WSBEiJ_G0027125
 protein coding gene Chr3:133892289-133994631 (+)



Homology
more
  • Human Ortholog
    DKK2, dickkopf WNT signaling pathway inhibitor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DKK2, dickkopf WNT signaling pathway inhibitor 2
  • Synonyms
    DKK-2
  • Links
    NCBI Gene ID: 27123
    neXtProt AC: NX_Q9UBU2
    UniProt: Q9UBU2

  • Chr Location
    4q25; chr4:106921802-107283806 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
mice homozygous for a targeted disruption are osteopenic with defective mineralization of induced osteoblasts in culture.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1108
  • Tissues
    312
  • cDNA Data
    25
  • Literature Summary
    64
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028031 Ensembl Gene Model | MGI Sequence Detail 95013 C57BL/6J ±  kb
    transcript ENSMUST00000029665 Ensembl | MGI Sequence Detail 3705 Not Applicable  
    polypeptide ENSMUSP00000029665 Ensembl | MGI Sequence Detail 259 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000006500 dickkopf-related protein 2
      (term hierarchy)
    • PDB
      2JTK
    • InterPro Domains
      IPR006796 Dickkopf, N-terminal cysteine-rich
      IPR048500 Dickkopf-related protein 1/2/4, C-terminal subdomain 1
      IPR048499 Dickkopf-related protein 1/2/4, C-terminal subdomain 2
      IPR039863 Dickkopf related protein 1-4
      IPR047303 Dickkopf-related protein 2, first cysteine-rich domain
      IPR047302 Dickkopf-related protein 2, second cysteine-rich domain
    • GlyGen
      Q9QYZ8 1 site
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 27
      Primer pair 16
      Other 7

      Microarray probesets 3
    References
    more
    • Summaries
      All 113
      Developmental Gene Expression 64
      Diseases 1
      Gene Ontology 6
      Phenotypes 28
    • Earliest
      J:57798 Monaghan AP, et al., Dickkopf genes are co-ordinately expressed in mesodermal lineages. Mech Dev. 1999 Sep;87(1-2):45-56
    • Latest
      J:352719 Pina JO, et al., Spatial Multi-omics Reveals the Role of the Wnt Modulator, Dkk2, in Palatogenesis'. J Dent Res. 2024 Jun 23;:220345241256600
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory