Ndufv3 MGI Mouse Gene Detail - MGI:1890894 - NADH:ubiquinone oxidoreductase core subunit V3

Symbol

Ndufv3
Name

NADH:ubiquinone oxidoreductase core subunit V3
Synonyms

1500032D16Rik

Feature Type

protein coding gene
IDs

MGI:1890894
NCBI Gene: 78330
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr17:31739089-31750300 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 16.64 cM, cytoband B2
Mapping Data

3 experiments

SNPs within 2kb

499 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1890894	protein coding gene	Chr17:31739089-31750305 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023490	protein coding gene	Chr17:31301024-31312177 (+)
A/J	MGP_AJ_G0023448	protein coding gene	Chr17:30267215-30279290 (+)
AKR/J	MGP_AKRJ_G0023413	protein coding gene	Chr17:30530043-30543854 (+)
BALB/cJ	MGP_BALBcJ_G0023453	protein coding gene	Chr17:30363214-30374357 (+)
C3H/HeJ	MGP_C3HHeJ_G0023214	protein coding gene	Chr17:30909417-30920625 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023895	protein coding gene	Chr17:32375692-32388256 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021369	protein coding gene	Chr17:27393692-27405343 (+)
CAST/EiJ	MGP_CASTEiJ_G0022715	protein coding gene	Chr17:30954185-30966328 (+)
CBA/J	MGP_CBAJ_G0023189	protein coding gene	Chr17:33782862-33799388 (+)
DBA/2J	MGP_DBA2J_G0023319	protein coding gene	Chr17:29668614-29679818 (+)
FVB/NJ	MGP_FVBNJ_G0023289	protein coding gene	Chr17:29462169-29475292 (+)
LP/J	MGP_LPJ_G0023397	protein coding gene	Chr17:31519298-31532387 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023307	protein coding gene	Chr17:32865577-32877425 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023937	protein coding gene	Chr17:30897595-30908738 (+)
PWK/PhJ	MGP_PWKPhJ_G0022465	protein coding gene	Chr17:28537914-28550078 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022283	protein coding gene	Chr17:28882191-28895969 (+)
WSB/EiJ	MGP_WSBEiJ_G0022777	protein coding gene	Chr17:30855577-30870827 (+)

Human Ortholog

NDUFV3, NADH:ubiquinone oxidoreductase subunit V3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NDUFV3, NADH:ubiquinone oxidoreductase subunit V3
Synonyms

CI-10k, CI-9KD
Links

HGNC:7719

NCBI Gene ID: 4731

neXtProt AC: NX_P56181

UniProt: P56181
Chr Location

21q22.3; chr21:42879644-42913304 (+) GRCh38

MGI Vertebrate Homology

Ndufv3 stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: NDUFV3
Gene Tree

Ndufv3

less

References

3 with disease annotations

less

Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
34 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

39
Endonuclease-mediated

2
Gene trapped

32
Targeted

5
Genomic Mutations

4 involving Ndufv3
Find Mice (IMSR)

20 strains or lines available

less

All GO Annotations

13
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

909
Tissues

156
cDNA Data

14
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

56
RefSeq

4
UniProt

7
CCDS

CCDS37549.1, CCDS37550.1

Ensembl

ENSMUSG00000024038 (Evidence)
NCBI Gene

78330

			Length	Strain/Species	Flank
genomic	78330	NCBI Gene Model \| MGI Sequence Detail	11212	C57BL/6J	± kb
transcript	NM_030087	RefSeq \| MGI Sequence Detail	1594	C57BL/6
polypeptide	Q8BK30	UniProt \| EBI \| MGI Sequence Detail	104	Not Applicable

less

UniProt

7 Sequences
Protein Ontology

PR:000011106 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

(term hierarchy)
PDB

6G2J, 6G72, 6ZR2, 6ZTQ, 7AK5, 7AK6, 7B93, 7PSA, 8C2S, 8CA3, 8CA4, 8CA5, 8OLT, 8OM1, 8PW5, 8PW6, 8PW7, 8RGP, 8RGQ, 8RGR, 8RGT
InterPro Domains

IPR026193 NADH-ubiquinone oxidoreductase flavoprotein 3
GlyGen

Q8BK30 1 site, 1 O-linked glycan (1 site)

less

All nucleic 18

Genomic 1

cDNA 14

Primer pair 2

Other 1

Microarray probesets 4

less

MGI:1925580

Summaries

All 67

Developmental Gene Expression 5

Diseases 3

Gene Ontology 8

Phenotypes 34
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:357279 Donovan MG, et al., Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome. Cell Rep. 2024 Aug 27;43(8):114599

TSS for Ndufv3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143670	Chr17:31739107-31739143 (+)	36 bp
Tssr143671	Chr17:31739144-31739185 (+)	76 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24