Kcne4 Gene Detail

Summary

• Symbol
  Kcne4
• Name
  potassium voltage-gated channel, Isk-related subfamily, gene 4
• Synonyms
  MiRP3

• Feature Type
  protein coding gene
• IDs
  MGI:1891125
  NCBI Gene: 57814
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr1:78794628-78797749 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 1, 40.89 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  151 from dbSNP Build 142
• Strain Annotations
  18
• PCR
  1

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891125	protein coding gene	Chr1:78794475-78797749 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016203	protein coding gene	Chr1:79578305-79581588 (+)
A/J	MGP_AJ_G0016186	protein coding gene	Chr1:76769802-76773096 (+)
AKR/J	MGP_AKRJ_G0016143	protein coding gene	Chr1:78885997-78889271 (+)
BALB/cJ	MGP_BALBcJ_G0016141	protein coding gene	Chr1:76867505-76870795 (+)
C3H/HeJ	MGP_C3HHeJ_G0015971	protein coding gene	Chr1:79235874-79239164 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016594	protein coding gene	Chr1:82657434-82660704 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014314	protein coding gene	Chr1:72179818-72183083 (+)
CAST/EiJ	MGP_CASTEiJ_G0015556	protein coding gene	Chr1:78615030-78618306 (+)
CBA/J	MGP_CBAJ_G0015945	protein coding gene	Chr1:85359902-85363172 (+)
DBA/2J	MGP_DBA2J_G0016046	protein coding gene	Chr1:76088167-76091437 (+)
FVB/NJ	MGP_FVBNJ_G0016049	protein coding gene	Chr1:75248773-75252029 (+)
LP/J	MGP_LPJ_G0016118	protein coding gene	Chr1:80697593-80700884 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016069	protein coding gene	Chr1:88577889-88581159 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016641	protein coding gene	Chr1:79007336-79010588 (+)
PWK/PhJ	MGP_PWKPhJ_G0015342	protein coding gene	Chr1:75550657-75553945 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015120	protein coding gene	Chr1:78331669-78334966 (+)
WSB/EiJ	MGP_WSBEiJ_G0015617	protein coding gene	Chr1:78793348-78796638 (+)

Homology

• Human Ortholog
  KCNE4, potassium voltage-gated channel subfamily E regulatory subunit 4

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  KCNE4, potassium voltage-gated channel subfamily E regulatory subunit 4
  
• Synonyms
  MIRP3
• Links
  HGNC:6244

  NCBI Gene ID: 23704

  neXtProt AC: NX_Q8WWG9

  UniProt: Q8WWG9

  
  
• Chr Location
  2q36.1; chr2:223052190-223198399 (+)  GRCh38

---

• MGI Vertebrate Homology
  Kcne4 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: KCNE4
• Gene Tree
  Kcne4
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotypes from 1 allele in 1 genetic background
  8 phenotype references
  

• All Mutations and Alleles
  7
• Chemically induced (other)
  1
• Radiation induced
  1
• Targeted
  5
• Genomic Mutations
  2 involving Kcne4
• Incidental Mutations
  APF
• Find Mice (IMSR)
  15 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Homozygous deletion of this gene impairs cardiac ventricular repolarization in an age and sex-dependent manner, with a prolonged QT interval only occurring similarly in both males and females after female menopause.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  24
• GO References
  11

Expression

• Assay Results
  712
• Tissues
  6
• cDNA Data
  16
• Literature Summary
  2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase kcne4

Sequences &
Gene Models

• All Sequences
  37
• RefSeq
  2
• UniProt
  3
• CCDS
  CCDS15088.1

• Ensembl
  ENSMUSG00000047330 (Evidence)
• NCBI Gene
  57814

Representative Sequences			Length	Strain/Species
genomic	57814	NCBI Gene Model | MGI Sequence Detail	3122	C57BL/6J
transcript	NM_021342	RefSeq | MGI Sequence Detail	2524	C57BL/6
polypeptide	Q9WTW3	UniProt | EBI | MGI Sequence Detail	170	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000009258 potassium voltage-gated channel subfamily E member 4
  (term hierarchy)
• InterPro Domains
  IPR000369 Potassium channel, voltage-dependent, beta subunit, KCNE
• GlyGen
  Q9WTW3 2 sites

Molecular
Reagents

• All nucleic 18

  cDNA 16

  Primer pair 2

  
  

  Microarray probesets 3

Other
Accession IDs

MGI:2138590

References

• Summaries
  All 38

  Developmental Gene Expression 2

  Gene Ontology 11

  Phenotypes 8
• Earliest
  J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
• Latest
  J:352579 Sole L, et al., Functional Consequences of the Variable Stoichiometry of the Kv1.3-KCNE4 Complex. Cells. 2020 May 2;9(5)

TSS for Kcne4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7586	Chr1:78794626-78794630 (+)	0 bp