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Chst2 Gene Detail
Summary
  • Symbol
    Chst2
  • Name
    carbohydrate sulfotransferase 2
  • Synonyms
    C130041E03Rik, Gn6st, GST-2, N-acetylglucosamine-6-O-sulfotransferase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891160
    NCBI Gene: 54371
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:95282979-95289323 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 50.11 cM, cytoband E3.2-3.3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    190 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891160
 protein coding gene Chr9:95281345-95289323 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035133
 protein coding gene Chr9:96510297-96517797 (-)
A/J MGP_AJ_G0035114
 protein coding gene Chr9:93167406-93174625 (-)
AKR/J MGP_AKRJ_G0035046
 protein coding gene Chr9:95410682-95420035 (-)
BALB/cJ MGP_BALBcJ_G0035107
 protein coding gene Chr9:92853713-92860935 (-)
C3H/HeJ MGP_C3HHeJ_G0034817
 protein coding gene Chr9:95853327-95861837 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035627
 protein coding gene Chr9:99269501-99276908 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032529
 protein coding gene Chr9:91000542-91007649 (-)
CAST/EiJ MGP_CASTEiJ_G0034129
 protein coding gene Chr9:95571452-95577988 (-)
CBA/J MGP_CBAJ_G0034785
 protein coding gene Chr9:102709909-102717139 (-)
DBA/2J MGP_DBA2J_G0034947
 protein coding gene Chr9:92696930-92704143 (-)
FVB/NJ MGP_FVBNJ_G0034895
 protein coding gene Chr9:91547502-91554791 (-)
LP/J MGP_LPJ_G0035026
 protein coding gene Chr9:96763883-96771114 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034934
 protein coding gene Chr9:104728099-104735465 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035649
 protein coding gene Chr9:95627239-95634557 (-)
PWK/PhJ MGP_PWKPhJ_G0033836
 protein coding gene Chr9:92835136-92842519 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033671
 protein coding gene Chr9:95641008-95648256 (-)
WSB/EiJ MGP_WSBEiJ_G0034249
 protein coding gene Chr9:95507928-95515278 (-)



Homology
more
  • Human Ortholog
    CHST2, carbohydrate sulfotransferase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHST2, carbohydrate sulfotransferase 2
  • Synonyms
    C6ST, glcNAc6ST-1, Gn6ST-1, GST-2, GST2, HEL-S-75
  • Links
    NCBI Gene ID: 9435
    neXtProt AC: NX_Q9Y4C5
    UniProt: Q9Y4C5

  • Chr Location
    3q24; chr3:143119771-143124014 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display decreased lymphocyte binding to peripheral lymph node high endothelial venules, and significantly reduced lymphocyte homing to Peyer's patches, peripheral and mesenteric lymph nodes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1029
  • Tissues
    198
  • cDNA Data
    20
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54371 NCBI Gene Model | MGI Sequence Detail 6345 C57BL/6J ±  kb
    transcript NM_018763 RefSeq | MGI Sequence Detail 6256 C57BL/6  
    polypeptide Q80WV3 UniProt | EBI | MGI Sequence Detail 530 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 20
      Primer pair 4
      Other 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2143044, MGI:2143292, MGI:2444728
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 16
      Gene Ontology 7
      Phenotypes 24
    • Earliest
      J:49573 Uchimura K, et al., Molecular cloning and characterization of an N-acetylglucosamine-6-O-sulfotransferase. J Biol Chem. 1998 Aug 28;273(35):22577-83
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory