Scel MGI Mouse Gene Detail - MGI:1891228

Symbol

Scel
Name

sciellin
Synonyms

9230114I02Rik

Feature Type

protein coding gene
IDs

MGI:1891228
NCBI Gene: 64929
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr14:103750778-103850233 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 52.51 cM, cytoband E
Mapping Data

5 experiments

SNPs within 2kb

3296 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891228	protein coding gene	Chr14:103750499-103850782 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021631	protein coding gene	Chr14:100030989-100137010 (+)
A/J	MGP_AJ_G0021589	protein coding gene	Chr14:96716122-96816298 (+)
AKR/J	MGP_AKRJ_G0021565	protein coding gene	Chr14:99618819-99719970 (+)
BALB/cJ	MGP_BALBcJ_G0021595	protein coding gene	Chr14:97055554-97163060 (+)
C3H/HeJ	MGP_C3HHeJ_G0021373	protein coding gene	Chr14:99511499-99615282 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022035	protein coding gene	Chr14:104069881-104170206 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019575	protein coding gene	Chr14:93571297-93674829 (+)
CAST/EiJ	MGP_CASTEiJ_G0020890	protein coding gene	Chr14:96846741-96951983 (+)
CBA/J	MGP_CBAJ_G0021341	protein coding gene	Chr14:107793581-107898200 (+)
DBA/2J	MGP_DBA2J_G0021465	protein coding gene	Chr14:96207775-96308692 (+)
FVB/NJ	MGP_FVBNJ_G0021442	protein coding gene	Chr14:95174270-95280982 (+)
LP/J	MGP_LPJ_G0021533	protein coding gene	Chr14:100838765-100943502 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021469	protein coding gene	Chr14:110658269-110768177 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022058	protein coding gene	Chr14:99140718-99240755 (+)
PWK/PhJ	MGP_PWKPhJ_G0020633	protein coding gene	Chr14:93208318-93313419 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020471	protein coding gene	Chr14:95171530-95277559 (+)
WSB/EiJ	MGP_WSBEiJ_G0020943	protein coding gene	Chr14:99798076-99901466 (+)

Human Ortholog

SCEL, sciellin

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SCEL, sciellin
Links

HGNC:10573

NCBI Gene ID: 8796

neXtProt AC: NX_O95171

UniProt: O95171
Chr Location

13q22.3; chr13:77535674-77645263 (+) GRCh38

MGI Vertebrate Homology

Scel stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SCEL
Gene Tree

Scel

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

1
Genomic Mutations

1 involving Scel
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

46 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice are viable and fertile with normal hair morphology and development and normal skin morphology and barrier function.

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All GO Annotations

16
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

748
Tissues

34
cDNA Data

23
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase scel

ZFIN scel

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All Sequences

45
RefSeq

6
UniProt

4
CCDS

CCDS37002.1

Ensembl

ENSMUSG00000022123 (Evidence)
NCBI Gene

64929

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022123	Ensembl Gene Model \| MGI Sequence Detail	99456	C57BL/6J	± kb
transcript	ENSMUST00000095576	Ensembl \| MGI Sequence Detail	2424	Not Applicable
polypeptide	ENSMUSP00000093233	Ensembl \| MGI Sequence Detail	652	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014499 sciellin

(term hierarchy)
InterPro Domains

IPR052621 Cell Proliferation and Cornified Envelope Regulator

IPR001781 Zinc finger, LIM-type

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All nucleic 23

cDNA 23

Microarray probesets 4

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MGI:1925008

Summaries

All 34

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 6
Earliest

J:66221 Champliaud MF, et al., Gene characterization of sciellin (SCEL) and protein localization in vertebrate epithelia displaying barrier properties. Genomics. 2000 Dec 1;70(2):264-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Scel:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr127066	Chr14:103750740-103750760 (+)	-28 bp
Tssr127067	Chr14:103750764-103750813 (+)	11 bp
Tssr127068	Chr14:103750814-103750865 (+)	62 bp
Tssr127069	Chr14:103750874-103750879 (+)	99 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24