Gprc5a MGI Mouse Gene Detail - MGI:1891250 - G protein-coupled receptor, family C, group 5, member A

Symbol

Gprc5a
Name

G protein-coupled receptor, family C, group 5, member A
Synonyms

Gprc5a, Rai3, Raig1

Feature Type

protein coding gene
IDs

MGI:1891250
NCBI Gene: 232431
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr6:135042660-135061707 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 65.83 cM
Mapping Data

3 experiments

SNPs within 2kb

794 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891250	protein coding gene	Chr6:135042649-135061707 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031413	protein coding gene	Chr6:139388131-139413519 (+)
A/J	MGP_AJ_G0031389	protein coding gene	Chr6:133899742-133919645 (+)
AKR/J	MGP_AKRJ_G0031316	protein coding gene	Chr6:137962891-137984825 (+)
BALB/cJ	MGP_BALBcJ_G0031395	protein coding gene	Chr6:133716303-133738948 (+)
C3H/HeJ	MGP_C3HHeJ_G0031117	protein coding gene	Chr6:138007510-138028719 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031855	protein coding gene	Chr6:143159511-143192539 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028987	protein coding gene	Chr6:133045257-133066169 (+)
CAST/EiJ	MGP_CASTEiJ_G0030486	protein coding gene	Chr6:137437986-137458563 (+)
CBA/J	MGP_CBAJ_G0031076	protein coding gene	Chr6:148507214-148530909 (+)
DBA/2J	MGP_DBA2J_G0031234	protein coding gene	Chr6:132749833-132768739 (+)
FVB/NJ	MGP_FVBNJ_G0031184	protein coding gene	Chr6:131660915-131680164 (+)
LP/J	MGP_LPJ_G0031318	protein coding gene	Chr6:139482390-139502656 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031224	protein coding gene	Chr6:152543619-152563759 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031888	protein coding gene	Chr6:137710311-137733417 (+)
PWK/PhJ	MGP_PWKPhJ_G0030211	protein coding gene	Chr6:131248417-131268076 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030035	protein coding gene	Chr6:135887260-135909142 (+)
WSB/EiJ	MGP_WSBEiJ_G0030577	protein coding gene	Chr6:138351395-138371063 (+)

Human Ortholog

GPRC5A, G protein-coupled receptor class C group 5 member A

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPRC5A, G protein-coupled receptor class C group 5 member A
Synonyms

GPCR5A, PEIG-1, RAI3, RAIG1, TIG1
Links

HGNC:9836

NCBI Gene ID: 9052

neXtProt AC: NX_Q8NFJ5

UniProt: Q8NFJ5
Chr Location

12p13.1; chr12:12890782-12917937 (+) GRCh38

MGI Vertebrate Homology

Gprc5a stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: GPRC5A
Gene Tree

Gprc5a

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Phenotype Summary

14 phenotypes from 3 alleles in 3 genetic backgrounds
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

44
Endonuclease-mediated

2
Gene trapped

38
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for one knock-out allele are healthy and exhibit normal lung development and a normal life span. A different homozygous KO allele causes a significantly increased incidence of acidophilic macrophage pneumonia and spontaneous lung tumors at 1-2 years of age. Another different homozygous KO results in age-related and diabetes-related pathology in kidney glomeruli.

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All GO Annotations

14
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

884
Tissues

53
cDNA Data

4
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gprc5a

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All Sequences

32
RefSeq

4
UniProt

2
CCDS

CCDS20644.1

Ensembl

ENSMUSG00000046733 (Evidence)
NCBI Gene

232431

			Length	Strain/Species	Flank
genomic	232431	NCBI Gene Model \| MGI Sequence Detail	19048	C57BL/6J	± kb
transcript	NM_181444	RefSeq \| MGI Sequence Detail	2072	C57BL/6
polypeptide	Q8BHL4	UniProt \| EBI \| MGI Sequence Detail	356	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008194 retinoic acid-induced protein 3

(term hierarchy)
InterPro Domains

IPR017978 GPCR family 3, C-terminal

IPR051753 Retinoic acid-inducible GPCR family 3
GlyGen

Q8BHL4 2 sites, 1 O-linked glycan (1 site)

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All nucleic 8

cDNA 4

Primer pair 1

Other 3

Microarray probesets 1

Summaries

All 52

Developmental Gene Expression 6

Gene Ontology 5

Phenotypes 29
Earliest

J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
Latest

J:349910 Han G, et al., An atlas of epithelial cell states and plasticity in lung adenocarcinoma. Nature. 2024 Mar;627(8004):656-663

TSS for Gprc5a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr59279	Chr6:135042664-135042680 (+)	12 bp
Tssr59280	Chr6:135055669-135055707 (+)	13,028 bp
Tssr59281	Chr6:135055709-135055767 (+)	13,078 bp
Tssr59282	Chr6:135061068-135061081 (+)	18,415 bp
Tssr59283	Chr6:135061170-135061193 (+)	18,522 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24