About   Help   FAQ
Kcnk6 Gene Detail
Summary
  • Symbol
    Kcnk6
  • Name
    potassium inwardly-rectifying channel, subfamily K, member 6
  • Synonyms
    D7Ertd764e, Toss, Twik2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891291
    NCBI Gene: 52150
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:28921351-28931940 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 16.94 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    378 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891291
 protein coding gene Chr7:28921351-28931947 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031977
 protein coding gene Chr7:28130173-28141790 (-)
A/J MGP_AJ_G0031955
 protein coding gene Chr7:27391014-27403180 (-)
AKR/J MGP_AKRJ_G0031888
 protein coding gene Chr7:28111656-28124379 (-)
BALB/cJ MGP_BALBcJ_G0031962
 protein coding gene Chr7:27587435-27600675 (-)
C3H/HeJ MGP_C3HHeJ_G0031681
 protein coding gene Chr7:28508456-28520165 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032427
 protein coding gene Chr7:29029292-29040134 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029477
 protein coding gene Chr7:28447084-28457390 (-)
CAST/EiJ MGP_CASTEiJ_G0031015
 protein coding gene Chr7:21767432-21778084 (-)
CBA/J MGP_CBAJ_G0031647
 protein coding gene Chr7:30390615-30401149 (-)
DBA/2J MGP_DBA2J_G0031799
 protein coding gene Chr7:27137015-27147550 (-)
FVB/NJ MGP_FVBNJ_G0031756
 protein coding gene Chr7:27245003-27257008 (-)
LP/J MGP_LPJ_G0031879
 protein coding gene Chr7:28432698-28444790 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031791
 protein coding gene Chr7:29772569-29784851 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032456
 protein coding gene Chr7:27594594-27606127 (-)
PWK/PhJ MGP_PWKPhJ_G0030741
 protein coding gene Chr7:22188515-22200435 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030574
 protein coding gene Chr7:18607285-18617855 (-)
WSB/EiJ MGP_WSBEiJ_G0031125
 protein coding gene Chr7:27963453-27977630 (-)



Homology
more
  • Human Ortholog
    KCNK6, potassium two pore domain channel subfamily K member 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNK6, potassium two pore domain channel subfamily K member 6
  • Synonyms
    K2p6.1, KCNK8, TOSS, TWIK-2, TWIK2
  • Links
    NCBI Gene ID: 9424
    neXtProt AC: NX_Q9Y257
    UniProt: Q9Y257

  • Chr Location
    19q13.2; chr19:38319845-38332076 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a knock-out allele exhibit vascular dysfunction and hypertension.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    5
  • cDNA Data
    31
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046410 Ensembl Gene Model | MGI Sequence Detail 10590 C57BL/6J ±  kb
    transcript ENSMUST00000085818 Ensembl | MGI Sequence Detail 4084 Not Applicable  
    polypeptide ENSMUSP00000082975 Ensembl | MGI Sequence Detail 313 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR013099 Potassium channel domain
      IPR003280 Two pore domain potassium channel
      IPR003092 Two pore domain potassium channel, TASK family
      IPR005409 Two pore domain potassium channel, TWIK-2
      IPR005408 Two pore domain potassium channel, TWIK family
    • GlyGen
      Q3TBV4 1 site
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 31
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1289340
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:343544 Zhi Y, et al., A novel TWIK2 channel inhibitor binds at the bottom of the selectivity filter and protects against LPS-induced experimental endotoxemia in vivo. Biochem Pharmacol. 2023 Dec;218:115894
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory