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Ube3b Gene Detail
Summary
  • Symbol
    Ube3b
  • Name
    ubiquitin protein ligase E3B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891295
    NCBI Gene: 117146
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:114518668-114559230 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 55.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1217 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891295
 protein coding gene Chr5:114518578-114559230 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029937
 protein coding gene Chr5:117116571-117157252 (+)
A/J MGP_AJ_G0029902
 protein coding gene Chr5:112518500-112559077 (+)
AKR/J MGP_AKRJ_G0029840
 protein coding gene Chr5:116089685-116130337 (+)
BALB/cJ MGP_BALBcJ_G0029913
 protein coding gene Chr5:113882821-113923447 (+)
C3H/HeJ MGP_C3HHeJ_G0029633
 protein coding gene Chr5:116589244-116632004 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030367
 protein coding gene Chr5:121641602-121682203 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027595
 protein coding gene Chr5:107341605-107382739 (+)
CAST/EiJ MGP_CASTEiJ_G0029041
 protein coding gene Chr5:115527084-115568898 (+)
CBA/J MGP_CBAJ_G0029600
 protein coding gene Chr5:126283699-126324966 (+)
DBA/2J MGP_DBA2J_G0029750
 protein coding gene Chr5:112576493-112617129 (+)
FVB/NJ MGP_FVBNJ_G0029707
 protein coding gene Chr5:111383157-111424729 (+)
LP/J MGP_LPJ_G0029839
 protein coding gene Chr5:117684980-117727573 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029738
 protein coding gene Chr5:130709693-130750252 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030408
 protein coding gene Chr5:115558981-115600786 (+)
PWK/PhJ MGP_PWKPhJ_G0028755
 protein coding gene Chr5:111216494-111262325 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028593
 protein coding gene Chr5:113095787-113141303 (+)
WSB/EiJ MGP_WSBEiJ_G0029117
 protein coding gene Chr5:116128158-116168718 (+)



Homology
more
  • Human Ortholog
    UBE3B, ubiquitin protein ligase E3B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UBE3B, ubiquitin protein ligase E3B
  • Synonyms
    BPIDS, KOS
  • Links
    NCBI Gene ID: 89910
    neXtProt AC: NX_Q7Z3V4
    UniProt: Q7Z3V4

  • Chr Location
    12q24.11; chr12:109477402-109547829 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ube3b mouse models; 1 with human UBE3B associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 3 alleles in 3 genetic backgrounds
    4 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit preweaning lethality, reduced fertility, decreased growth, reduced grip strength, impaired hearing, eye inflammation and decreased cholesterol level.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    822
  • Tissues
    111
  • cDNA Data
    219
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029577 Ensembl Gene Model | MGI Sequence Detail 40563 C57BL/6J ±  kb
    transcript ENSMUST00000074002 Ensembl | MGI Sequence Detail 5194 Not Applicable  
    polypeptide ENSMUSP00000073652 Ensembl | MGI Sequence Detail 1070 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 221
      cDNA 219
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2140892, MGI:2141051
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 4
      Phenotypes 17
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory