Lpin3 MGI Mouse Gene Detail - MGI:1891342

Symbol

Lpin3
Name

lipin 3
Synonyms

9130206L11Rik

Feature Type

protein coding gene
IDs

MGI:1891342
NCBI Gene: 64899
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:160722590-160747920 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 80.98 cM
Mapping Data

4 experiments

SNPs within 2kb

792 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891342	protein coding gene	Chr2:160722590-160747922 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026808	protein coding gene	Chr2:166081381-166107728 (+)
A/J	MGP_AJ_G0026774	protein coding gene	Chr2:159408332-159433607 (+)
AKR/J	MGP_AKRJ_G0026745	protein coding gene	Chr2:164119468-164144783 (+)
BALB/cJ	MGP_BALBcJ_G0026783	protein coding gene	Chr2:159720698-159746990 (+)
C3H/HeJ	MGP_C3HHeJ_G0026525	protein coding gene	Chr2:164454382-164481820 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027232	protein coding gene	Chr2:170996277-171021391 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024602	protein coding gene	Chr2:152791538-152808776 (+)
CAST/EiJ	MGP_CASTEiJ_G0025987	protein coding gene	Chr2:164835167-164864265 (+)
CBA/J	MGP_CBAJ_G0026502	protein coding gene	Chr2:177159172-177186634 (+)
DBA/2J	MGP_DBA2J_G0026640	protein coding gene	Chr2:158587854-158612898 (+)
FVB/NJ	MGP_FVBNJ_G0026607	protein coding gene	Chr2:156988787-157014263 (+)
LP/J	MGP_LPJ_G0026743	protein coding gene	Chr2:166188948-166215070 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026628	protein coding gene	Chr2:180854934-180881242 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027288	protein coding gene	Chr2:163958638-163985914 (+)
PWK/PhJ	MGP_PWKPhJ_G0025721	protein coding gene	Chr2:158134689-158160087 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025524	protein coding gene	Chr2:162838357-162863723 (+)
WSB/EiJ	MGP_WSBEiJ_G0026057	protein coding gene	Chr2:164853726-164878875 (+)

Human Ortholog

LPIN3, lipin 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LPIN3, lipin 3
Synonyms

dJ620E11.2, LIPN3L, SMP2
Links

HGNC:14451

NCBI Gene ID: 64900

neXtProt AC: NX_Q9BQK8

UniProt: Q9BQK8
Chr Location

20q12; chr20:41340821-41360582 (+) GRCh38

MGI Vertebrate Homology

Lpin3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LPIN3
Gene Tree

Lpin3

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Phenotype Summary

13 phenotypes from 2 alleles in 3 genetic backgrounds
6 phenotypes from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

3
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

52 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele show slightly decreased body weight, especially with age, and abnormal adipogenesis.

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

761
Tissues

16
cDNA Data

45
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lpin3

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All Sequences

54
RefSeq

6
UniProt

6
CCDS

CCDS16998.1

Ensembl

ENSMUSG00000027412 (Evidence)
NCBI Gene

64899

			Length	Strain/Species	Flank
genomic	64899	NCBI Gene Model \| MGI Sequence Detail	25331	C57BL/6J	± kb
transcript	NM_022883	RefSeq \| MGI Sequence Detail	3498	C57BL/6
polypeptide	Q99PI4	UniProt \| EBI \| MGI Sequence Detail	848	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000009896 phosphatidate phosphatase LPIN3

(term hierarchy)
EC

3.1.3.4
InterPro Domains

IPR036412 HAD-like superfamily

IPR023214 HAD superfamily

IPR026058 LIPIN family

IPR031703 Lipin, middle domain

IPR013209 Lipin/Ned1/Smp2 (LNS2)

IPR007651 Lipin, N-terminal

IPR031315 LNS2/PITP

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All nucleic 46

cDNA 45

Primer pair 1

Microarray probesets 3

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MGI:2139260, MGI:2442081, MGI:3034319

Summaries

All 40

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 13
Earliest

J:66739 Peterfy M, et al., Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin. Nat Genet. 2001 Jan;27(1):121-4
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lpin3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21408	Chr2:160722562-160722570 (+)	-24 bp
Tssr21409	Chr2:160722618-160722646 (+)	42 bp
Tssr21410	Chr2:160722648-160722667 (+)	68 bp
Tssr21411	Chr2:160730021-160730033 (+)	7,437 bp
Tssr21412	Chr2:160730076-160730119 (+)	7,508 bp
Tssr21413	Chr2:160733893-160733919 (+)	11,316 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24