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Prg4 Gene Detail
Summary
  • Symbol
    Prg4
  • Name
    proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
  • Synonyms
    DOL54, lubricin, MSF, SZP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891344
    NCBI Gene: 96875
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:150325163-150341916 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 63.84 cM, cytoband G
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    471 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891344
 protein coding gene Chr1:150325163-150341916 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016577
 protein coding gene Chr1:155097239-155114287 (-)
A/J MGP_AJ_G0016559
 protein coding gene Chr1:148850889-148866982 (-)
AKR/J MGP_AKRJ_G0016524
 protein coding gene Chr1:153399479-153415831 (-)
BALB/cJ MGP_BALBcJ_G0016519
 protein coding gene Chr1:149378864-149394688 (-)
C3H/HeJ MGP_C3HHeJ_G0016344
 protein coding gene Chr1:153580422-153596442 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016980
 protein coding gene Chr1:160474800-160491553 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014689
 protein coding gene Chr1:141207742-141224588 (-)
CAST/EiJ MGP_CASTEiJ_G0015923
 protein coding gene Chr1:152976996-152993750 (-)
CBA/J MGP_CBAJ_G0016318
 protein coding gene Chr1:166142032-166157954 (-)
DBA/2J MGP_DBA2J_G0016424
 protein coding gene Chr1:147904570-147920987 (-)
FVB/NJ MGP_FVBNJ_G0016422
 protein coding gene Chr1:146358609-146374646 (-)
LP/J MGP_LPJ_G0016495
 protein coding gene Chr1:156131084-156147322 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016448
 protein coding gene Chr1:173836896-173854529 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017016
 protein coding gene Chr1:153211381-153227470 (-)
PWK/PhJ MGP_PWKPhJ_G0015709
 protein coding gene Chr1:146820837-146837254 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015496
 protein coding gene Chr1:151997782-152013603 (-)
WSB/EiJ MGP_WSBEiJ_G0015986
 protein coding gene Chr1:153286260-153303176 (-)



Homology
more
  • Human Ortholog
    PRG4, proteoglycan 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRG4, proteoglycan 4
  • Synonyms
    CACP, HAPO, JCAP, MSF, SZP
  • Links
    NCBI Gene ID: 10216
    neXtProt AC: NX_Q92954
    UniProt: Q92954

  • Chr Location
    1q31.1; chr1:186296273-186314567 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PRG4 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    3 images
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Aging homozygous null mice develop a hopping gait, irregular endochondral growth plates, altered cartilage surface, camptodactyly, progressive synovial hyperplasia and, ultimately, joint failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    763
  • Tissues
    22
  • cDNA Data
    9
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 96875 NCBI Gene Model | MGI Sequence Detail 16754 C57BL/6J ±  kb
    transcript NM_021400 RefSeq | MGI Sequence Detail 4278 Not Specified  
    polypeptide Q9JM99 UniProt | EBI | MGI Sequence Detail 1054 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 9
      Primer pair 1
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 91
      Developmental Gene Expression 24
      Gene Ontology 6
      Phenotypes 46
    • Earliest
      J:75732 Kuroda M, et al., Induction of a secreted protein by the myxoid liposarcoma oncogene. Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5025-30
    • Latest
      J:354893 Fidler TP, et al., Suppression of IL-1beta promotes beneficial accumulation of fibroblast-like cells in atherosclerotic plaques in clonal hematopoiesis. Nat Cardiovasc Res. 2024 Jan;3(1):60-75
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory