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Fgf23 Gene Detail
Summary
  • Symbol
    Fgf23
  • Name
    fibroblast growth factor 23
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891427
    NCBI Gene: 64654
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:127049865-127058371 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 61.92 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    327 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891427
 protein coding gene Chr6:127049865-127059257 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031311
 protein coding gene Chr6:130554914-130563418 (+)
A/J MGP_AJ_G0031282
 protein coding gene Chr6:125598264-125606749 (+)
AKR/J MGP_AKRJ_G0031210
 protein coding gene Chr6:128996817-129005326 (+)
BALB/cJ MGP_BALBcJ_G0031289
 protein coding gene Chr6:125156470-125164890 (+)
C3H/HeJ MGP_C3HHeJ_G0031013
 protein coding gene Chr6:129114937-129123428 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031746
 protein coding gene Chr6:133961094-133969608 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028894
 protein coding gene Chr6:122772264-122780880 (+)
CAST/EiJ MGP_CASTEiJ_G0030394
 protein coding gene Chr6:129310339-129320273 (+)
CBA/J MGP_CBAJ_G0030974
 protein coding gene Chr6:139112782-139121228 (+)
DBA/2J MGP_DBA2J_G0031130
 protein coding gene Chr6:124485318-124493803 (+)
FVB/NJ MGP_FVBNJ_G0031079
 protein coding gene Chr6:123412487-123421100 (+)
LP/J MGP_LPJ_G0031210
 protein coding gene Chr6:130669692-130678142 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031118
 protein coding gene Chr6:143072988-143081439 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031781
 protein coding gene Chr6:128946347-128954811 (+)
PWK/PhJ MGP_PWKPhJ_G0030109
 protein coding gene Chr6:122756864-122765366 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029938
 protein coding gene Chr6:127027018-127035402 (+)
WSB/EiJ MGP_WSBEiJ_G0030479
 protein coding gene Chr6:129311047-129319507 (+)



Homology
more
  • Human Ortholog
    FGF23, fibroblast growth factor 23
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGF23, fibroblast growth factor 23
  • Synonyms
    ADHR, FGFN, HFTC2, HPDR2, HYPF, PHPTC
  • Links
    NCBI Gene ID: 8074
    neXtProt AC: NX_Q9GZV9
    UniProt: Q9GZV9

  • Chr Location
    12p13.32; chr12:4368227-4379712 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Fgf23 mouse models; 1 with human FGF23 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    63 phenotypes from 5 alleles in 7 genetic backgrounds
    30 phenotypes from multigenic genotypes
    2 images
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are severely growth retarded and die prematurely. They exhibit hypophosphatemia, abnormal vitamin D metabolism, renal defects, skeletal defects, and are infertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    922
  • Tissues
    173
  • cDNA Data
    7
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000182 Ensembl Gene Model | MGI Sequence Detail 8507 C57BL/6J ±  kb
    transcript ENSMUST00000000186 Ensembl | MGI Sequence Detail 1814 Not Applicable  
    polypeptide ENSMUSP00000000186 Ensembl | MGI Sequence Detail 251 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 7
      Primer pair 5
      Other 4

      Microarray probesets 2
    References
    more
    • Summaries
      All 208
      Developmental Gene Expression 21
      Diseases 3
      Gene Ontology 11
      Phenotypes 67
    • Earliest
      J:65463 White KE, et al., Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. Nat Genet. 2000 Nov;26(3):345-8
    • Latest
      J:346441 Jung YS, et al., ERRgamma-inducible FGF23 promotes alcoholic liver injury through enhancing CYP2E1 mediated hepatic oxidative stress. Redox Biol. 2024 Mar 5;71:103107
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory