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Pcdhac2 Gene Detail
Summary
  • Symbol
    Pcdhac2
  • Name
    protocadherin alpha subfamily C, 2
  • Synonyms
    CNRc2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891443
    NCBI Gene: 353237
  • Member of
    Pcdha cluster
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:37276731-37320716 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 19.46 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1137 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891443
 protein coding gene Chr18:37276556-37320716 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024309
 protein coding gene Chr18:35538408-35583235 (+)
A/J MGP_AJ_G0024276
 protein coding gene Chr18:34313359-34357515 (+)
AKR/J MGP_AKRJ_G0024244
 protein coding gene Chr18:35269293-35313391 (+)
BALB/cJ MGP_BALBcJ_G0024275
 protein coding gene Chr18:34362228-34406362 (+)
C3H/HeJ MGP_C3HHeJ_G0024042
 protein coding gene Chr18:35314004-35358175 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024717
 protein coding gene Chr18:36823463-36867648 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022156
 protein coding gene Chr18:34391800-34436126 (+)
CAST/EiJ MGP_CASTEiJ_G0023517
 protein coding gene Chr18:35312006-35356123 (+)
CBA/J MGP_CBAJ_G0024011
 protein coding gene Chr18:37901745-37945878 (+)
DBA/2J MGP_DBA2J_G0024141
 protein coding gene Chr18:33919589-33963728 (+)
FVB/NJ MGP_FVBNJ_G0024108
 protein coding gene Chr18:33645457-33689539 (+)
LP/J MGP_LPJ_G0024225
 protein coding gene Chr18:35632299-35676922 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024137
 protein coding gene Chr18:39174773-39218915 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024766
 protein coding gene Chr18:35136466-35180644 (+)
PWK/PhJ MGP_PWKPhJ_G0023261
 protein coding gene Chr18:34156387-34203479 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023066
 protein coding gene Chr18:35395325-35441752 (+)
WSB/EiJ MGP_WSBEiJ_G0023580
 protein coding gene Chr18:35035536-35081773 (+)



Homology
more
  • Human Ortholog
    PCDHAC2, protocadherin alpha subfamily C, 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PCDHAC2, protocadherin alpha subfamily C, 2
  • Synonyms
    PCDH-ALPHA-C2
  • Links
    NCBI Gene ID: 56134
    neXtProt AC: NX_Q9Y5I4
    UniProt: Q9Y5I4

  • Chr Location
    5q31.3; chr5:140966470-141012347 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Mice homozygous for a reporter allele are viable and fertile with no apparent gross phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    4
  • cDNA Data
    2
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 353237 NCBI Gene Model | MGI Sequence Detail 43986 C57BL/6J ±  kb
transcript NM_001003672 RefSeq | MGI Sequence Detail 5719 C57BL/6  
polypeptide NP_001003672 RefSeq | MGI Sequence Detail 1006 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • PDB
    4ZPM
  • InterPro Domains
    IPR020894 Cadherin conserved site
    IPR031904 Cadherin, C-terminal catenin-binding domain
    IPR032455 Cadherin, cytoplasmic C-terminal domain
    IPR002126 Cadherin-like
    IPR015919 Cadherin-like superfamily
    IPR013164 Cadherin, N-terminal
    IPR050174 Protocadherin/Cadherin-related Cell Adhesion
  • GlyGen
    Q91Y09 7 sites, 5 N-linked glycans (5 sites)
Molecular
Reagents
less
  • All nucleic 5
    cDNA 2
    Primer pair 3
References
more
  • Summaries
    All 30
    Developmental Gene Expression 6
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:67989 Wu Q, et al., Comparative dna sequence analysis of mouse and human protocadherin gene clusters. Genome Res. 2001 Mar;11(3):389-404
  • Latest
    J:332241 Kobayashi H, et al., Isoform requirement of clustered protocadherin for preventing neuronal apoptosis and neonatal lethality. iScience. 2023 Jan 20;26(1):105766
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory