Peli2 MGI Mouse Gene Detail - MGI:1891445

Symbol

Peli2
Name

pellino 2

Feature Type

protein coding gene
IDs

MGI:1891445
NCBI Gene: 93834
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr14:48358280-48519032 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 24.60 cM
Mapping Data

3 experiments

SNPs within 2kb

4852 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891445	protein coding gene	Chr14:48358096-48519035 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021225	protein coding gene	Chr14:41940361-42089016 (+)
A/J	MGP_AJ_G0021174	protein coding gene	Chr14:40648106-40787029 (+)
AKR/J	MGP_AKRJ_G0021152	protein coding gene	Chr14:42229102-42372021 (+)
BALB/cJ	MGP_BALBcJ_G0021177	protein coding gene	Chr14:40696435-40838121 (+)
C3H/HeJ	MGP_C3HHeJ_G0020960	protein coding gene	Chr14:42017148-42164912 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021612	protein coding gene	Chr14:43686031-43834597 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019171	protein coding gene	Chr14:39982667-40123531 (+)
CAST/EiJ	MGP_CASTEiJ_G0020486	protein coding gene	Chr14:39143679-39293936 (+)
CBA/J	MGP_CBAJ_G0020927	protein coding gene	Chr14:45108136-45258528 (+)
DBA/2J	MGP_DBA2J_G0021050	protein coding gene	Chr14:40531642-40671374 (+)
FVB/NJ	MGP_FVBNJ_G0021035	protein coding gene	Chr14:40272077-40412327 (+)
LP/J	MGP_LPJ_G0021119	protein coding gene	Chr14:42193697-42340638 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021060	protein coding gene	Chr14:44427825-44570825 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021645	protein coding gene	Chr14:41766700-41909948 (+)
PWK/PhJ	MGP_PWKPhJ_G0020234	protein coding gene	Chr14:37412810-37554888 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020059	protein coding gene	Chr14:37903868-38048533 (+)
WSB/EiJ	MGP_WSBEiJ_G0020542	protein coding gene	Chr14:41871241-42015398 (+)

Human Ortholog

PELI2, pellino E3 ubiquitin protein ligase family member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PELI2, pellino E3 ubiquitin protein ligase family member 2
Links

HGNC:8828

NCBI Gene ID: 57161

neXtProt AC: NX_Q9HAT8

UniProt: Q9HAT8
Chr Location

14q22.3; chr14:56117814-56301524 (+) GRCh38

MGI Vertebrate Homology

Peli2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PELI2
Protein SuperFamily

Pellino
Gene Tree

Peli2

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Targeted

1
Genomic Mutations

1 involving Peli2
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout reduces the immune response to gram-negative bacteria.

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All GO Annotations

13
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

924
Tissues

39
cDNA Data

9
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase peli2

ZFIN peli2

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All Sequences

60
RefSeq

9
UniProt

6
CCDS

CCDS36901.1

Ensembl

ENSMUSG00000021846 (Evidence)
NCBI Gene

93834

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021846	Ensembl Gene Model \| MGI Sequence Detail	160753	C57BL/6J	± kb
transcript	ENSMUST00000247875	Ensembl \| MGI Sequence Detail	5900	Not Applicable
polypeptide	ENSMUSP00000159539	Ensembl \| MGI Sequence Detail	472	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000012539 E3 ubiquitin-protein ligase pellino homolog 2

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR006800 Pellino family

IPR048334 Pellino, FHA domain

IPR048335 Pellino, RING domain

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All nucleic 12

cDNA 11

Primer pair 1

Microarray probesets 5

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MGI:2145788, MGI:2145853

Summaries

All 34

Developmental Gene Expression 5

Gene Ontology 6

Phenotypes 5
Earliest

J:68867 Resch K, et al., Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping. Cytogenet Cell Genet. 2001;92(1-2):172-4
Latest

J:342723 Oleszycka E, et al., Dendritic Cell-Specific Role for Pellino2 as a Mediator of TLR9 Signaling Pathway. J Immunol. 2021 Nov 1;207(9):2325-2336

TSS for Peli2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125333	Chr14:48358197-48358239 (+)	-62 bp
Tssr125334	Chr14:48358267-48358285 (+)	-4 bp
Tssr125335	Chr14:48358298-48358322 (+)	30 bp
Tssr125336	Chr14:48358330-48358413 (+)	92 bp
Tssr125337	Chr14:48358415-48358424 (+)	140 bp
Tssr4391	Chr14:48488021-48488043 (+)	129,752 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24