Ripk2 MGI Mouse Gene Detail - MGI:1891456 - receptor (TNFRSF)-interacting serine-threonine kinase 2

Symbol

Ripk2
Name

receptor (TNFRSF)-interacting serine-threonine kinase 2
Synonyms

2210420D18Rik, CARD3, CARDIAK, CCK, D4Bwg0615e, RICK, RIP2

Feature Type

protein coding gene
IDs

MGI:1891456
NCBI Gene: 192656
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr4:16122733-16163647 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 6.70 cM
Mapping Data

4 experiments

SNPs within 2kb

1057 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891456	protein coding gene	Chr4:16122733-16163674 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028076	protein coding gene	Chr4:13009781-13059001 (-)
A/J	MGP_AJ_G0028034	protein coding gene	Chr4:12688039-12728861 (-)
AKR/J	MGP_AKRJ_G0027999	protein coding gene	Chr4:12926876-12966625 (-)
BALB/cJ	MGP_BALBcJ_G0028045	protein coding gene	Chr4:12605476-12646125 (-)
C3H/HeJ	MGP_C3HHeJ_G0027775	protein coding gene	Chr4:13030058-13069765 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028488	protein coding gene	Chr4:13543648-13583070 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025830	protein coding gene	Chr4:11853209-11890852 (-)
CAST/EiJ	MGP_CASTEiJ_G0027230	protein coding gene	Chr4:12858642-12899419 (-)
CBA/J	MGP_CBAJ_G0027748	protein coding gene	Chr4:13875768-13920462 (-)
DBA/2J	MGP_DBA2J_G0027891	protein coding gene	Chr4:12510491-12550237 (-)
FVB/NJ	MGP_FVBNJ_G0027857	protein coding gene	Chr4:12268398-12306978 (-)
LP/J	MGP_LPJ_G0028000	protein coding gene	Chr4:13049570-13090700 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027890	protein coding gene	Chr4:14225575-14269502 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028547	protein coding gene	Chr4:12876072-12916804 (-)
PWK/PhJ	MGP_PWKPhJ_G0026950	protein coding gene	Chr4:12483590-12517109 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026779	protein coding gene	Chr4:12751356-12789509 (-)
WSB/EiJ	MGP_WSBEiJ_G0027307	protein coding gene	Chr4:12912410-12954484 (-)

Human Ortholog

RIPK2, receptor interacting serine/threonine kinase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RIPK2, receptor interacting serine/threonine kinase 2
Synonyms

CARD3, CARDIAK, CCK, GIG30, RICK, RIP2
Links

HGNC:10020

NCBI Gene ID: 8767

neXtProt AC: NX_O43353

UniProt: O43353
Chr Location

8q21.3; chr8:89757806-89791064 (+) GRCh38

MGI Vertebrate Homology

Ripk2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RIPK2
Gene Tree

Ripk2

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Phenotype Summary

11 phenotypes from 4 alleles in 5 genetic backgrounds
3 phenotypes from multigenic genotypes
90 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

3
Gene trapped

2
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available

Homozygous inactivation of this gene leads to impaired cytokine production in response to LPS treatment, and may result in resistance to LPS-induced septic shock and defects in Toll-like receptor and T-cell receptor signaling. Macrophages homozygous for a knock-in allele show normal LPS signaling.

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All GO Annotations

157
GO References

21

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

28

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

53
RefSeq

9
UniProt

3
CCDS

CCDS17988.1

Ensembl

ENSMUSG00000041135 (Evidence)
NCBI Gene

192656

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041135	Ensembl Gene Model \| MGI Sequence Detail	40915	C57BL/6J	± kb
transcript	ENSMUST00000037035	Ensembl \| MGI Sequence Detail	2692	Not Applicable
polypeptide	ENSMUSP00000038833	Ensembl \| MGI Sequence Detail	539	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014023 receptor-interacting serine/threonine-protein kinase 2

(term hierarchy)
EC

2.7.10.2, 2.7.11.1
InterPro Domains

IPR001315 CARD domain

IPR011029 Death-like domain superfamily

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR017322 Receptor-interacting serine/threonine-protein kinase 2

IPR042149 RIP2, CARD domain

IPR050167 Serine/threonine-protein kinase

IPR008271 Serine/threonine-protein kinase, active site

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
GlyGen

P58801 1 site, 1 O-linked glycan (1 site)

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All nucleic 29

cDNA 28

Primer pair 1

Microarray probesets 3

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MGD-MRK-34205, MGI:106511, MGI:1917420

Summaries

All 140

Gene Ontology 21

Phenotypes 90
Earliest

J:35447 Corradi A, et al., cDNA sequence, map, and expression of the murine homolog of GTBP, a DNA mismatch repair gene. Genomics. 1996 Sep 1;36(2):288-95
Latest

J:329456 Spring J, et al., Gut commensal bacteria enhance pathogenesis of a tumorigenic murine retrovirus. Cell Rep. 2022 Sep 13;40(11):111341

TSS for Ripk2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr40992	Chr4:16163611-16163625 (-)	29 bp
Tssr40991	Chr4:16163512-16163533 (-)	124 bp
Tssr40990	Chr4:16163492-16163505 (-)	148 bp
Tssr40989	Chr4:16147152-16147167 (-)	16,487 bp
Tssr40988	Chr4:16145741-16145753 (-)	17,900 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24