Nek6 MGI Mouse Gene Detail - MGI:1891638 - NIMA (never in mitosis gene a)-related expressed kinase 6

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Nek6 Gene Detail

Symbol

Nek6
Name

NIMA (never in mitosis gene a)-related expressed kinase 6
Synonyms

1300007C09Rik

Feature Type

protein coding gene
IDs

MGI:1891638
NCBI Gene: 59126
Alliance

gene page
Transcription Start Sites

14 TSS
Candidate for QTL

1 QTL

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Sequence Map

Chr2:38401655-38484618 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 24.41 cM
Mapping Data

3 experiments

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SNPs within 2kb

1875 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_1891638	protein coding gene	Chr2:38314052-38484618 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025702	protein coding gene	Chr2:37270533-37354200 (+)
A/J	MGP_AJ_G0025679	protein coding gene	Chr2:35737402-35818030 (+)
AKR/J	MGP_AKRJ_G0025649	protein coding gene	Chr2:36918910-36999474 (+)
BALB/cJ	MGP_BALBcJ_G0025674	protein coding gene	Chr2:35788464-35871595 (+)
C3H/HeJ	MGP_C3HHeJ_G0025435	protein coding gene	Chr2:36831456-36915097 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026120	protein coding gene	Chr2:38303558-38392385 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023525	protein coding gene	Chr2:34391890-34473326 (+)
CAST/EiJ	MGP_CASTEiJ_G0024898	protein coding gene	Chr2:36780548-36864220 (+)
CBA/J	MGP_CBAJ_G0025414	protein coding gene	Chr2:39741323-39824417 (+)
DBA/2J	MGP_DBA2J_G0025546	protein coding gene	Chr2:35484344-35565450 (+)
FVB/NJ	MGP_FVBNJ_G0025508	protein coding gene	Chr2:35350686-35431940 (+)
LP/J	MGP_LPJ_G0025633	protein coding gene	Chr2:37148431-37232548 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025539	protein coding gene	Chr2:39350858-39431956 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026178	protein coding gene	Chr2:36808823-36890138 (+)
PWK/PhJ	MGP_PWKPhJ_G0024640	protein coding gene	Chr2:35384244-35467152 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024445	protein coding gene	Chr2:36917031-37000803 (+)
WSB/EiJ	MGP_WSBEiJ_G0024966	protein coding gene	Chr2:36976782-37061628 (+)

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Human Ortholog

NEK6, NIMA related kinase 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NEK6, NIMA related kinase 6
Synonyms

SID6-1512
Links

HGNC:7749

NCBI Gene ID: 10783

neXtProt AC: NX_Q9HC98

UniProt: Q9HC98
Chr Location

9q33.3; chr9:124257606-124353307 (+) GRCh38

MGI Vertebrate Homology

Nek6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NEK6
Protein SuperFamily

Integrin-linked_kinase
Gene Tree

Nek6

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Phenotype Summary

8 phenotypes from 1 allele in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

119
Endonuclease-mediated

4
Gene trapped

112
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

94 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

No significant homozygous or heterozygous mutant phenotype was detected in a high throughput screen of a targeted mutation, however these homozygotes exhibit an increased response of the heart to induced stress, with aggravated cardiac hypertrophy.

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All GO Annotations

65
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

850
Tissues

142
cDNA Data

73
Literature Summary

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nek6

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All Sequences

72
RefSeq

14
UniProt

4
CCDS

CCDS16009.1

Ensembl

ENSMUSG00000026749 (Evidence)
NCBI Gene

59126

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000026749	Ensembl Gene Model \| MGI Sequence Detail	82964	C57BL/6J	± kb
	transcript	ENSMUST00000054234	Ensembl \| MGI Sequence Detail	10338	Not Applicable
	polypeptide	ENSMUSP00000049723	Ensembl \| MGI Sequence Detail	313	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000011132 serine/threonine-protein kinase Nek6

(term hierarchy)
EC

2.7.11.34
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

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All nucleic 74

cDNA 73

Primer pair 1

Microarray probesets 6

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MGI:1914728

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Summaries

All 50

Developmental Gene Expression 4

Gene Ontology 12

Phenotypes 11
Earliest

J:58906 Kandli M, et al., Isolation and characterization of two evolutionarily conserved murine kinases (Nek6 and nek7) related to the fungal mitotic regulator, NIMA. Genomics. 2000 Sep 1;68(2):187-96
Latest

J:346594 Shao S, et al., Never in mitosis gene A-related kinase-6 deficiency deteriorates diabetic cardiomyopathy via regulating heat shock protein 72. J Mol Med (Berl). 2023 Apr;101(4):419-430

TSS for Nek6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr17550	Chr2:38401503-38401535 (+)	-136 bp
Tssr17551	Chr2:38401559-38401563 (+)	-94 bp
Tssr17552	Chr2:38401682-38401759 (+)	66 bp
Tssr17553	Chr2:38401885-38401896 (+)	236 bp
Tssr17554	Chr2:38403252-38403262 (+)	1,602 bp
Tssr17555	Chr2:38407369-38407397 (+)	5,728 bp
Tssr17556	Chr2:38412336-38412351 (+)	10,689 bp
Tssr17557	Chr2:38423701-38423707 (+)	22,049 bp
Tssr17558	Chr2:38423814-38423815 (+)	22,160 bp
Tssr17559	Chr2:38426139-38426156 (+)	24,493 bp
Tssr17560	Chr2:38426617-38426628 (+)	24,968 bp
Tssr17561	Chr2:38426876-38426879 (+)	25,223 bp
Tssr17562	Chr2:38476090-38476101 (+)	74,441 bp
Tssr17563	Chr2:38477921-38477925 (+)	76,268 bp

Nek6 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Nidd5	Chr2, 31.66 cM		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 2, Nek6 showed differential expression between A/a and A/A animals on the restricted diet. Diabesity QTL Nidd5 (34.5 cM) maps near this candidate gene.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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