Hnrnpr MGI Mouse Gene Detail - MGI:1891692 - heterogeneous nuclear ribonucleoprotein R

Symbol

Hnrnpr
Name

heterogeneous nuclear ribonucleoprotein R
Synonyms

2610003J05Rik, 2610528B01Rik, hnRNPR, Hnrpr

Feature Type

protein coding gene
IDs

MGI:1891692
NCBI Gene: 74326
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr4:136038253-136086758 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 68.40 cM, cytoband D3
Mapping Data

3 experiments

SNPs within 2kb

985 from dbSNP Build 142
Strain Annotations

13

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891692	protein coding gene	Chr4:136038230-136086758 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028965	protein coding gene	Chr4:138854710-138909899 (+)
A/J	no annotation
AKR/J	no annotation
BALB/cJ	MGP_BALBcJ_G0028948	protein coding gene	Chr4:133602767-133652064 (+)
C3H/HeJ	MGP_C3HHeJ_G0028662	protein coding gene	Chr4:137060568-137110589 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029389	protein coding gene	Chr4:143797244-143881632 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026660	protein coding gene	Chr4:125981729-126031658 (+)
CAST/EiJ	no annotation
CBA/J	MGP_CBAJ_G0028627	protein coding gene	Chr4:147717001-147783201 (+)
DBA/2J	MGP_DBA2J_G0028776	protein coding gene	Chr4:133359231-133408577 (+)
FVB/NJ	MGP_FVBNJ_G0028743	protein coding gene	Chr4:132303786-132351795 (+)
LP/J	no annotation
NOD/ShiLtJ	MGP_NODShiLtJ_G0028769	protein coding gene	Chr4:151948340-152003377 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029427	protein coding gene	Chr4:137247051-137300264 (+)
PWK/PhJ	MGP_PWKPhJ_G0027814	protein coding gene	Chr4:130137258-130188427 (+)
SPRET/EiJ	no annotation
WSB/EiJ	MGP_WSBEiJ_G0028172	protein coding gene	Chr4:137414419-137464488 (+)

Human Ortholog

HNRNPR, heterogeneous nuclear ribonucleoprotein R

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HNRNPR, heterogeneous nuclear ribonucleoprotein R
Synonyms

hnRNP-R, HNRPR, NEDDFSB
Links

HGNC:5047

NCBI Gene ID: 10236

neXtProt AC: NX_O43390

UniProt: O43390
Chr Location

1p36.12; chr1:23303771-23344336 (-) GRCh38

MGI Vertebrate Homology

Hnrnpr stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HNRNPR
Gene Tree

Hnrnpr

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

42
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

35
Targeted

3
Genomic Mutations

3 involving Hnrnpr
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

48 strains or lines available

Mice homozygous for a knock-out allele in which expression of the full-length isoform is abolished while expression of the N-terminally truncated isoform is retained are viable and survive to adulthood with no overt phenotypic defects. In culture, primary motoneurons from these mice do not exhibit axonal growth defects but show increased accumulation of double strand breaks and an impaired DNA damage response upon exposure to genotoxic agents.

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All GO Annotations

14
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

761
Tissues

47
cDNA Data

22
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA HNRNPR

Xenbase hnrnpr

ZFIN hnrnpr

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All Sequences

131
RefSeq

39
UniProt

13
CCDS

CCDS18805.1, CCDS71495.1

Ensembl

ENSMUSG00000066037 (Evidence)
NCBI Gene

74326

			Length	Strain/Species	Flank
genomic	ENSMUSG00000066037	Ensembl Gene Model \| MGI Sequence Detail	48506	C57BL/6J	± kb
transcript	ENSMUST00000148843	Ensembl \| MGI Sequence Detail	21452	Not Applicable
polypeptide	ENSMUSP00000138399	Ensembl \| MGI Sequence Detail	632	Not Applicable

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UniProt

13 Sequences
InterPro Domains

IPR041337 Heterogeneous nuclear ribonucleoprotein Q acidic domain

IPR034410 Heterogeneous nuclear ribonucleoprotein R, RNA recognition motif 1

IPR034411 Heterogeneous nuclear ribonucleoprotein R, RNA recognition motif 2

IPR006535 HnRNP R/Q splicing factor

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain
GlyGen

Q8VHM5 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 24

cDNA 22

Primer pair 1

Other 1

Microarray probesets 10

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MGI:1917292, MGI:1921576

Summaries

All 50

Developmental Gene Expression 9

Gene Ontology 4

Phenotypes 15
Earliest

J:64914 Mizutani A, et al., SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms. J Biol Chem. 2000 Mar 31;275(13):9823-31
Latest

J:337970 Salehi S, et al., Cytosolic Ptbp2 modulates axon growth in motoneurons through axonal localization and translation of Hnrnpr. Nat Commun. 2023 Jul 12;14(1):4158

TSS for Hnrnpr:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39700	Chr4:136038247-136038258 (+)	0 bp
Tssr39701	Chr4:136038263-136038295 (+)	26 bp
Tssr39702	Chr4:136038302-136038365 (+)	81 bp
Tssr39703	Chr4:136059764-136059770 (+)	21,514 bp
Tssr39704	Chr4:136059848-136059894 (+)	21,618 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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