Rnf130 MGI Mouse Gene Detail - MGI:1891717

Symbol

Rnf130
Name

ring finger protein 130
Synonyms

2510042A13Rik, G1RP, G1RZFP

Feature Type

protein coding gene
IDs

MGI:1891717
NCBI Gene: 59044
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:49916173-50016546 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 30.16 cM, cytoband B1.2
Mapping Data

3 experiments

SNPs within 2kb

2369 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891717	protein coding gene	Chr11:49916158-50016546 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018240	protein coding gene	Chr11:49174779-49261149 (+)
A/J	MGP_AJ_G0018208	protein coding gene	Chr11:47294843-47374351 (+)
AKR/J	MGP_AKRJ_G0018178	protein coding gene	Chr11:48798115-48880498 (+)
BALB/cJ	MGP_BALBcJ_G0018178	protein coding gene	Chr11:47573785-47655136 (+)
C3H/HeJ	MGP_C3HHeJ_G0017991	protein coding gene	Chr11:48798517-48880675 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018629	protein coding gene	Chr11:50640517-50724644 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016281	protein coding gene	Chr11:44914035-44995379 (+)
CAST/EiJ	MGP_CASTEiJ_G0017553	protein coding gene	Chr11:48776550-48857903 (+)
CBA/J	MGP_CBAJ_G0017966	protein coding gene	Chr11:52980651-53070425 (+)
DBA/2J	MGP_DBA2J_G0018073	protein coding gene	Chr11:47096396-47175492 (+)
FVB/NJ	MGP_FVBNJ_G0018067	protein coding gene	Chr11:46712345-46795649 (+)
LP/J	MGP_LPJ_G0018148	protein coding gene	Chr11:49514027-49598165 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018092	protein coding gene	Chr11:54515685-54611554 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018673	protein coding gene	Chr11:48897011-48990686 (+)
PWK/PhJ	MGP_PWKPhJ_G0017331	protein coding gene	Chr11:47488325-47573691 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017126	protein coding gene	Chr11:48600735-48681716 (+)
WSB/EiJ	MGP_WSBEiJ_G0017606	protein coding gene	Chr11:48549275-48633073 (+)

Human Ortholog

RNF130, ring finger protein 130

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNF130, ring finger protein 130
Synonyms

G1RP, G1RZFP, GOLIATH, GP
Links

HGNC:18280

NCBI Gene ID: 55819

neXtProt AC: NX_Q86XS8

UniProt: Q86XS8
Chr Location

5q35.3; chr5:179911651-180072113 (-) GRCh38

MGI Vertebrate Homology

Rnf130 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RNF130
Gene Tree

Rnf130

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

4
Targeted

3
Genomic Mutations

1 involving Rnf130
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a hypomorphic allele show partial prenatal lethality, increased hepatic low-density lipoprotein receptor (LDLR) protein levels, and decreased plasma LDL cholesterol (LDL-C) levels.

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All GO Annotations

12
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

793
Tissues

81
cDNA Data

11
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rnf130

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All Sequences

51
RefSeq

6
UniProt

4
CCDS

CCDS24626.1, CCDS78937.1, CCDS88150.1

Ensembl

ENSMUSG00000020376 (Evidence)
NCBI Gene

59044

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020376	Ensembl Gene Model \| MGI Sequence Detail	100374	C57BL/6J	± kb
transcript	ENSMUST00000102776	Ensembl \| MGI Sequence Detail	1502	Not Applicable
polypeptide	ENSMUSP00000099837	Ensembl \| MGI Sequence Detail	419	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014081 E3 ubiquitin-protein ligase RNF130

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR003137 PA domain

IPR046450 PA domain superfamily

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type
GlyGen

Q8VEM1 6 sites, 7 N-linked glycans (3 sites)

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All nucleic 13

Genomic 1

cDNA 11

Primer pair 1

Microarray probesets 3

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MGI:1919691

Summaries

All 46

Developmental Gene Expression 6

Gene Ontology 6

Phenotypes 13
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345488 Hao S, et al., Goliath induces inflammation in obese mice by linking fatty acid beta-oxidation to glycolysis. EMBO Rep. 2023 Apr 5;24(4):e56932

TSS for Rnf130:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101206	Chr11:49916108-49916123 (+)	-57 bp
Tssr101207	Chr11:49916136-49916201 (+)	-4 bp
Tssr101208	Chr11:49916203-49916212 (+)	35 bp
Tssr101209	Chr11:49916215-49916222 (+)	46 bp
Tssr101210	Chr11:49929867-49929868 (+)	13,695 bp
Tssr101211	Chr11:49962033-49962046 (+)	45,867 bp
Tssr101212	Chr11:50010419-50010435 (+)	94,254 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24