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Ppp4c Gene Detail
Summary
  • Symbol
    Ppp4c
  • Name
    protein phosphatase 4, catalytic subunit
  • Synonyms
    1110002D08Rik, PPX
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891763
    NCBI Gene: 56420
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126385038-126391668 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.25 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    183 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891763
 protein coding gene Chr7:126385038-126391729 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032999
 protein coding gene Chr7:131084226-131090843 (-)
A/J MGP_AJ_G0032982
 protein coding gene Chr7:127611631-127618268 (-)
AKR/J MGP_AKRJ_G0032914
 protein coding gene Chr7:130845367-130852000 (-)
BALB/cJ MGP_BALBcJ_G0032987
 protein coding gene Chr7:127273122-127279755 (-)
C3H/HeJ MGP_C3HHeJ_G0032697
 protein coding gene Chr7:130783059-130789689 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033493
 protein coding gene Chr7:136178623-136185253 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030465
 protein coding gene Chr7:128804046-128810897 (-)
CAST/EiJ MGP_CASTEiJ_G0032026
 protein coding gene Chr7:122569943-122576548 (-)
CBA/J MGP_CBAJ_G0032670
 protein coding gene Chr7:140762050-140768680 (-)
DBA/2J MGP_DBA2J_G0032822
 protein coding gene Chr7:125585399-125592029 (-)
FVB/NJ MGP_FVBNJ_G0032775
 protein coding gene Chr7:125434097-125440727 (-)
LP/J MGP_LPJ_G0032916
 protein coding gene Chr7:132554592-132561222 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032807
 protein coding gene Chr7:141943341-141951528 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033512
 protein coding gene Chr7:129851474-129858111 (-)
PWK/PhJ MGP_PWKPhJ_G0031733
 protein coding gene Chr7:118580372-118587007 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031579
 protein coding gene Chr7:116702452-116708943 (-)
WSB/EiJ MGP_WSBEiJ_G0032138
 protein coding gene Chr7:130832149-130838731 (-)



Homology
more
  • Human Ortholog
    PPP4C, protein phosphatase 4 catalytic subunit
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP4C, protein phosphatase 4 catalytic subunit
  • Synonyms
    PP4, PP4C, PPH3, PPP4, PP-X, PPX
  • Links
    NCBI Gene ID: 5531
    neXtProt AC: NX_P60510
    UniProt: P60510

  • Chr Location
    16p11.2; chr16:30075978-30085376 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ppp4c mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 4 alleles in 4 genetic backgrounds
    8 phenotypes from multigenic genotypes
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryonic Ppp4c-deficiency leads to early embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    766
  • Tissues
    16
  • cDNA Data
    116
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030697 Ensembl Gene Model | MGI Sequence Detail 6631 C57BL/6J ±  kb
    transcript ENSMUST00000032936 Ensembl | MGI Sequence Detail 1359 Not Applicable  
    polypeptide ENSMUSP00000032936 Ensembl | MGI Sequence Detail 307 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000013152 serine/threonine-protein phosphatase 4 catalytic subunit
      (term hierarchy)
    • EC
      3.1.3.16
    • InterPro Domains
      IPR004843 Calcineurin-like phosphoesterase domain, ApaH type
      IPR029052 Metallo-dependent phosphatase-like
      IPR047129 Serine/Threonine protein phosphatase PP2A-like
      IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
    • GlyGen
      P97470 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 118
      cDNA 117
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2142119
    References
    more
    • Summaries
      All 99
      Developmental Gene Expression 9
      Diseases 4
      Gene Ontology 14
      Phenotypes 54
    • Earliest
      J:64812 Hu MC, et al., Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity. J Biol Chem. 1998 Dec 11;273(50):33561-5
    • Latest
      J:354208 Dong MZ, et al., Protein phosphatase 4 maintains the survival of primordial follicles by regulating autophagy in oocytes. Cell Death Dis. 2024 Sep 8;15(9):658
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory