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Becn1 Gene Detail
Summary
  • Symbol
    Becn1
  • Name
    beclin 1, autophagy related
  • Synonyms
    Atg6, MGC:6843
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891828
    NCBI Gene: 56208
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:101179084-101193112 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 64.58 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    407 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891828
 protein coding gene Chr11:101176778-101193112 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019193
 protein coding gene Chr11:104132717-104146745 (-)
A/J MGP_AJ_G0019161
 protein coding gene Chr11:99755224-99769252 (-)
AKR/J MGP_AKRJ_G0019130
 protein coding gene Chr11:102855984-102870007 (-)
BALB/cJ MGP_BALBcJ_G0019135
 protein coding gene Chr11:100242147-100256171 (-)
C3H/HeJ MGP_C3HHeJ_G0018944
 protein coding gene Chr11:103031057-103045082 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019584
 protein coding gene Chr11:107383320-107397344 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017210
 protein coding gene Chr11:97168059-97182832 (-)
CAST/EiJ MGP_CASTEiJ_G0018498
 protein coding gene Chr11:104018667-104032969 (-)
CBA/J MGP_CBAJ_G0018913
 protein coding gene Chr11:111821420-111835444 (-)
DBA/2J MGP_DBA2J_G0019025
 protein coding gene Chr11:99284594-99298619 (-)
FVB/NJ MGP_FVBNJ_G0019015
 protein coding gene Chr11:98830950-98844974 (-)
LP/J MGP_LPJ_G0019094
 protein coding gene Chr11:104676411-104690436 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019046
 protein coding gene Chr11:111378503-111392909 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019622
 protein coding gene Chr11:103183604-103197629 (-)
PWK/PhJ MGP_PWKPhJ_G0018261
 protein coding gene Chr11:100338852-100353135 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018053
 protein coding gene Chr11:102921029-102934353 (-)
WSB/EiJ MGP_WSBEiJ_G0018547
 protein coding gene Chr11:103180193-103194218 (-)



Homology
more
  • Human Ortholog
    BECN1, beclin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BECN1, beclin 1
  • Synonyms
    ATG6, beclin1, VPS30
  • Links
    NCBI Gene ID: 8678
    neXtProt AC: NX_Q14457
    UniProt: Q14457

  • Chr Location
    17q21.31; chr17:42810132-42833350 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Becn1 mouse models; 1 with human BECN1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    72 phenotypes from 8 alleles in 11 genetic backgrounds
    8 phenotypes from multigenic genotypes
    1 images
    148 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit prenatal lethality. Mice heterozygous for this allele exhibit premature death, increased tumor incidence and reduced autophagy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    150
  • GO References
    35
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    846
  • Tissues
    87
  • cDNA Data
    9
  • Literature Summary
    30
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56208 NCBI Gene Model | MGI Sequence Detail 14029 C57BL/6J ±  kb
    transcript NM_001359820 RefSeq | MGI Sequence Detail 2140 C57BL/6  
    polypeptide O88597 UniProt | EBI | MGI Sequence Detail 448 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 13
      Primer pair 4

      Microarray probesets 7
    References
    more
    • Summaries
      All 266
      Developmental Gene Expression 30
      Diseases 1
      Gene Ontology 35
      Phenotypes 148
    • Earliest
      J:64816 Liang XH, et al., Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol. 1998 Nov;72(11):8586-96
    • Latest
      J:352324 Nakamura Y, et al., Neuronal activity promotes secretory autophagy for the extracellular release of alpha-synuclein. J Biol Chem. 2024 May 28;300(7):107419
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory