Sfn MGI Mouse Gene Detail - MGI:1891831

Symbol

Sfn
Name

stratifin
Synonyms

14-3-3, 14-3-3 sigma, Er, MME1, Ywhas

Feature Type

protein coding gene
IDs

MGI:1891831
NCBI Gene: 55948
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr4:133327867-133329163 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 66.25 cM, cytoband D3
Mapping Data

8 experiments

SNPs within 2kb

112 from dbSNP Build 142
Strain Annotations

12

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891831	protein coding gene	Chr4:133327867-133329479 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028901	protein coding gene	Chr4:135882427-135885408 (-)
A/J	MGP_AJ_G0028860	protein coding gene	Chr4:130183263-130184696 (-)
AKR/J	MGP_AKRJ_G0033659	protein coding gene	Chr8:71033563-71035250 (+)
BALB/cJ	MGP_BALBcJ_G0028883	protein coding gene	Chr4:130815498-130818552 (-)
C3H/HeJ	MGP_C3HHeJ_G0028597	protein coding gene	Chr4:134139469-134141004 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029325	protein coding gene	Chr4:140743288-140747393 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026596	protein coding gene	Chr4:123248224-123249464 (-)
CAST/EiJ	MGP_CASTEiJ_G0028030	protein coding gene	Chr4:132250886-132253873 (-)
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	MGP_FVBNJ_G0028679	protein coding gene	Chr4:129492148-129493560 (-)
LP/J	no annotation
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0029363	protein coding gene	Chr4:134304615-134307505 (-)
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	MGP_WSBEiJ_G0032880	protein coding gene	Chr8:71442523-71443345 (+)

Human Ortholog

SFN, stratifin

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SFN, stratifin
Synonyms

YWHAS
Links

HGNC:10773

NCBI Gene ID: 2810

neXtProt AC: NX_P31947

UniProt: P31947
Chr Location

1p36.11; chr1:26863149-26864456 (+) GRCh38

MGI Vertebrate Homology

Sfn stringent orthology
1 human;1 mouse;2 rat;2 zebrafish
HCOP

vertebrate homology predictions: SFN
Protein SuperFamily

14-3-3
Gene Tree

Sfn

Diseases

2 with human SFN associations

				Human Disease	Mouse Models
				transitional cell carcinoma IDs transitional cell carcinoma DOID:2671 DOID:3995 MESH:D002295 NCI:C2930 NCI:C6783 UMLS_CUI:C0007138 UMLS_CUI:C0334265
				vulva squamous cell carcinoma IDs vulva squamous cell carcinoma DOID:2101 NCI:C4052 UMLS_CUI:C0280856

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

94 phenotypes from 3 alleles in 6 genetic backgrounds
18 phenotypes from multigenic genotypes
12 images
40 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

2
Endonuclease-mediated

3
Radiation induced

2
Targeted

7
Genomic Mutations

4 involving Sfn
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Nullizygous mice show impaired B-cell homeostasis, BCR signaling, and T cell-independent B-cell responses. Homozygous hypomorphs show altered mammary epithelial morphology. Spontaneous mutants die at birth from respiratory stress with severe anomalies inskin, limbs, tails, face and oral cavity.

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All GO Annotations

51
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

879
Tissues

145
cDNA Data

104
Literature Summary

36

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

27
RefSeq

2
UniProt

2
CCDS

CCDS18754.1

Ensembl

ENSMUSG00000047281 (Evidence)
NCBI Gene

55948

			Length	Strain/Species	Flank
genomic	55948	NCBI Gene Model \| MGI Sequence Detail	1297	C57BL/6J	± kb
transcript	NM_018754	RefSeq \| MGI Sequence Detail	1297	ZRU/MplStud
polypeptide	O70456	UniProt \| EBI \| MGI Sequence Detail	248	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014742 14-3-3 protein sigma

(term hierarchy)
InterPro Domains

IPR023410 14-3-3 domain

IPR036815 14-3-3 domain superfamily

IPR000308 14-3-3 protein

IPR023409 14-3-3 protein, conserved site

IPR037435 14-3-3 protein sigma

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All nucleic 115

Genomic 1

cDNA 104

Primer pair 6

Other 4

Microarray probesets 4

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MGD-MRK-9568, MGI:95409

Summaries

All 111

Developmental Gene Expression 36

Gene Ontology 13

Phenotypes 40
Earliest

J:6200 Guenet JL, et al., Repeated epilation: a genetic epidermal syndrome in mice. J Hered. 1979 Mar-Apr;70(2):90-4
Latest

J:355487 Han Z, et al., The subcortical maternal complex modulates the cell cycle during early mammalian embryogenesis via 14-3-3. Nat Commun. 2024 Oct 15;15(1):8887

TSS for Sfn:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr43775	Chr4:133329203-133329215 (-)	-46 bp
Tssr43774	Chr4:133329182-133329200 (-)	-28 bp
Tssr43773	Chr4:133329150-133329179 (-)	-2 bp
Tssr43772	Chr4:133329133-133329149 (-)	22 bp
Tssr43771	Chr4:133328788-133328826 (-)	356 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24