Hdac7 MGI Mouse Gene Detail - MGI:1891835

Symbol

Hdac7
Name

histone deacetylase 7
Synonyms

5830434K02Rik, Hdac7a

Feature Type

protein coding gene
IDs

MGI:1891835
NCBI Gene: 56233
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr15:97690545-97742383 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 53.79 cM, cytoband F2
Mapping Data

2 experiments

SNPs within 2kb

1307 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891835	protein coding gene	Chr15:97690542-97742383 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022280	protein coding gene	Chr15:99465444-99507879 (-)
A/J	MGP_AJ_G0022239	protein coding gene	Chr15:95533819-95574293 (-)
AKR/J	MGP_AKRJ_G0022214	protein coding gene	Chr15:98414236-98454348 (-)
BALB/cJ	MGP_BALBcJ_G0022245	protein coding gene	Chr15:95757001-95795945 (-)
C3H/HeJ	MGP_C3HHeJ_G0022015	protein coding gene	Chr15:98493343-98534064 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022690	protein coding gene	Chr15:103138698-103179682 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020216	protein coding gene	Chr15:91478723-91518221 (-)
CAST/EiJ	MGP_CASTEiJ_G0021537	protein coding gene	Chr15:99361993-99417824 (-)
CBA/J	MGP_CBAJ_G0021982	protein coding gene	Chr15:106598351-106636744 (-)
DBA/2J	MGP_DBA2J_G0022109	protein coding gene	Chr15:94983147-95021766 (-)
FVB/NJ	MGP_FVBNJ_G0022088	protein coding gene	Chr15:93971602-94014533 (-)
LP/J	MGP_LPJ_G0022180	protein coding gene	Chr15:99573572-99617751 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022108	protein coding gene	Chr15:110717983-110757656 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022705	protein coding gene	Chr15:98564440-98602708 (-)
PWK/PhJ	MGP_PWKPhJ_G0021278	protein coding gene	Chr15:95080411-95134676 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021112	protein coding gene	Chr15:98335366-98376620 (-)
WSB/EiJ	MGP_WSBEiJ_G0021586	protein coding gene	Chr15:99083874-99138478 (-)

Human Ortholog

HDAC7, histone deacetylase 7

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HDAC7, histone deacetylase 7
Synonyms

HD7, HD7A, HDAC7A
Links

HGNC:14067

NCBI Gene ID: 51564

neXtProt AC: NX_Q8WUI4

UniProt: Q8WUI4
Chr Location

12q13.11; chr12:47782722-47833132 (-) GRCh38

MGI Vertebrate Homology

Hdac7 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: HDAC7
Protein SuperFamily

HDAC_II_euk
Gene Tree

Hdac7

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References

1 with disease annotations

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Phenotype Summary

18 phenotypes from 3 alleles in 3 genetic backgrounds
39 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

4
Radiation induced

2
Targeted

5
Genomic Mutations

3 involving Hdac7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

49 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Deletion of this gene result in embryonic lethality by E11, due to vascular defects which are due to endothelial cell adhesion defects.

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All GO Annotations

62
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

768
Tissues

25
cDNA Data

103
Literature Summary

19

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA HDAC7

Xenbase hdac7

ZFIN hdac7b

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All Sequences

121
RefSeq

41
UniProt

10
CCDS

CCDS37188.1, CCDS57001.1, CCDS57002.1, CCDS57003.1, CCDS57004.1, CCDS57005.1, CCDS57006.1, CCDS57007.1

Ensembl

ENSMUSG00000022475 (Evidence)
NCBI Gene

56233

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022475	Ensembl Gene Model \| MGI Sequence Detail	51839	C57BL/6J	± kb
transcript	ENSMUST00000116409	Ensembl \| MGI Sequence Detail	4113	Not Applicable
polypeptide	ENSMUSP00000112110	Ensembl \| MGI Sequence Detail	953	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000008486 histone deacetylase 7

(term hierarchy)
EC

3.5.1.-, 3.5.1.98
InterPro Domains

IPR046949 Histone deacetylase 4/5/7/9

IPR050284 Histone deacetylase and polyamine deacetylase

IPR023801 Histone deacetylase domain

IPR037138 Histone deacetylase domain superfamily

IPR000286 Histone deacetylase family

IPR023696 Ureohydrolase domain superfamily

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All nucleic 106

cDNA 103

Primer pair 3

Microarray probesets 4

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MGI:2443780

Summaries

All 103

Developmental Gene Expression 19

Diseases 1

Gene Ontology 16

Phenotypes 39
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Hdac7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136174	Chr15:97742793-97742816 (-)	-422 bp
Tssr136173	Chr15:97742135-97742199 (-)	216 bp
Tssr136172	Chr15:97742115-97742126 (-)	262 bp
Tssr136171	Chr15:97729418-97729461 (-)	12,943 bp
Tssr136170	Chr15:97729341-97729400 (-)	13,012 bp
Tssr136169	Chr15:97722667-97722672 (-)	19,713 bp
Tssr136168	Chr15:97721567-97721587 (-)	20,806 bp
Tssr136167	Chr15:97721540-97721552 (-)	20,837 bp
Tssr136166	Chr15:97721509-97721521 (-)	20,868 bp
Tssr136165	Chr15:97718867-97718903 (-)	23,498 bp
Tssr136164	Chr15:97712711-97712759 (-)	29,648 bp
Tssr136163	Chr15:97710132-97710149 (-)	32,242 bp
Tssr136162	Chr15:97706296-97706312 (-)	36,079 bp
Tssr136161	Chr15:97701644-97701657 (-)	40,732 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24