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Nrip2 Gene Detail
Summary
  • Symbol
    Nrip2
  • Name
    nuclear receptor interacting protein 2
  • Synonyms
    NIX1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891884
    NCBI Gene: 60345
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:128374780-128386747 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 62.99 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    426 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891884
 protein coding gene Chr6:128374780-128393390 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031325
 protein coding gene Chr6:132008536-132025753 (+)
A/J MGP_AJ_G0031296
 protein coding gene Chr6:126942091-126959202 (+)
AKR/J MGP_AKRJ_G0031224
 protein coding gene Chr6:130358950-130376052 (+)
BALB/cJ MGP_BALBcJ_G0031303
 protein coding gene Chr6:126517292-126534390 (+)
C3H/HeJ MGP_C3HHeJ_G0031027
 protein coding gene Chr6:130498565-130516657 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031762
 protein coding gene Chr6:135438421-135456956 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028908
 protein coding gene Chr6:124151366-124168596 (+)
CAST/EiJ MGP_CASTEiJ_G0030408
 protein coding gene Chr6:130791579-130810118 (+)
CBA/J MGP_CBAJ_G0030988
 protein coding gene Chr6:140665872-140686113 (+)
DBA/2J MGP_DBA2J_G0031144
 protein coding gene Chr6:125839941-125857326 (+)
FVB/NJ MGP_FVBNJ_G0031094
 protein coding gene Chr6:124767887-124785067 (+)
LP/J MGP_LPJ_G0031224
 protein coding gene Chr6:132127058-132144576 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031132
 protein coding gene Chr6:144503847-144522332 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031795
 protein coding gene Chr6:130373763-130390818 (+)
PWK/PhJ MGP_PWKPhJ_G0030123
 protein coding gene Chr6:124134247-124152065 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029952
 protein coding gene Chr6:128495664-128512616 (+)
WSB/EiJ MGP_WSBEiJ_G0030493
 protein coding gene Chr6:130769993-130787208 (+)



Homology
more
  • Human Ortholog
    NRIP2, nuclear receptor interacting protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NRIP2, nuclear receptor interacting protein 2
  • Links
    NCBI Gene ID: 83714
    neXtProt AC: NX_Q9BQI9
    UniProt: Q9BQI9

  • Chr Location
    12p13.33; chr12:2825348-2835544 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    749
  • Tissues
    41
  • cDNA Data
    8
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 60345 NCBI Gene Model | MGI Sequence Detail 11968 C57BL/6J ±  kb
transcript NM_001411380 RefSeq | MGI Sequence Detail 1867 C57BL/6  
polypeptide Q9JHR9 UniProt | EBI | MGI Sequence Detail 270 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • InterPro Domains
    IPR019103 Aspartic peptidase, DDI1-type
    IPR021109 Aspartic peptidase domain superfamily
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 5
Other
Accession IDs
less
MGI:2141681
References
more
  • Summaries
    All 28
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:63034 Greiner EF, et al., Differential ligand-dependent protein-protein interactions between nuclear receptors and a neuronal-specific cofactor. Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7160-5
  • Latest
    J:317698 Hou Q, et al., Nuclear Receptor Interacting Protein-2 Mediates the Stabilization and Activation of beta-Catenin During Podocyte Injury. Front Cell Dev Biol. 2021;9:781792
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory