Psrc1 MGI Mouse Gene Detail - MGI:1913099 - proline/serine-rich coiled-coil 1

Symbol

Psrc1
Name

proline/serine-rich coiled-coil 1
Synonyms

5430413I02Rik, DDA3

Feature Type

protein coding gene
IDs

MGI:1913099
NCBI Gene: 56742
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr3:108291155-108295547 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 47.01 cM
Mapping Data

2 experiments

SNPs within 2kb

170 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913099	protein coding gene	Chr3:108291120-108295547 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027775	protein coding gene	Chr3:109932614-109937005 (+)
A/J	MGP_AJ_G0027735	protein coding gene	Chr3:106443335-106447726 (+)
AKR/J	MGP_AKRJ_G0027700	protein coding gene	Chr3:109036752-109041143 (+)
BALB/cJ	MGP_BALBcJ_G0027747	protein coding gene	Chr3:106145193-106149583 (+)
C3H/HeJ	MGP_C3HHeJ_G0027477	protein coding gene	Chr3:109388481-109392872 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028191	protein coding gene	Chr3:114037274-114041665 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025529	protein coding gene	Chr3:102591973-102596591 (+)
CAST/EiJ	MGP_CASTEiJ_G0026933	protein coding gene	Chr3:108770914-108776250 (+)
CBA/J	MGP_CBAJ_G0027452	protein coding gene	Chr3:117918380-117922771 (+)
DBA/2J	MGP_DBA2J_G0027594	protein coding gene	Chr3:105627876-105632267 (+)
FVB/NJ	MGP_FVBNJ_G0027562	protein coding gene	Chr3:103512593-103516984 (+)
LP/J	MGP_LPJ_G0027701	protein coding gene	Chr3:111351028-111355418 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027592	protein coding gene	Chr3:123971249-123975642 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028246	protein coding gene	Chr3:108635993-108640417 (+)
PWK/PhJ	MGP_PWKPhJ_G0026659	protein coding gene	Chr3:105376904-105381410 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026479	protein coding gene	Chr3:106774608-106779190 (+)
WSB/EiJ	MGP_WSBEiJ_G0027013	protein coding gene	Chr3:109173129-109177519 (+)

Human Ortholog

PSRC1, proline and serine rich coiled-coil 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PSRC1, proline and serine rich coiled-coil 1
Synonyms

DDA3, FP3214
Links

HGNC:24472

NCBI Gene ID: 84722

neXtProt AC: NX_Q6PGN9

UniProt: Q6PGN9
Chr Location

1p13.3; chr1:109279556-109283186 (-) GRCh38

MGI Vertebrate Homology

Psrc1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PSRC1
Gene Tree

Psrc1

less

References

1 with disease annotations

less

Phenotype Summary

10 phenotype references

All Mutations and Alleles

16
Chemically induced (other)

1
Gene trapped

11
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Psrc1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

22 strains or lines available

less

All GO Annotations

29
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

822
Tissues

16
cDNA Data

99
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

59
RefSeq

4
UniProt

5
CCDS

CCDS17758.1

Ensembl

ENSMUSG00000068744 (Evidence)
NCBI Gene

56742

			Length	Strain/Species	Flank
genomic	ENSMUSG00000068744	Ensembl Gene Model \| MGI Sequence Detail	4393	C57BL/6J	± kb
transcript	ENSMUST00000090561	Ensembl \| MGI Sequence Detail	1686	Not Applicable
polypeptide	ENSMUSP00000088049	Ensembl \| MGI Sequence Detail	329	Not Applicable

less

UniProt

5 Sequences
Protein Ontology

PR:000013406 proline/serine-rich coiled-coil protein 1

(term hierarchy)
InterPro Domains

IPR032768 G2 and S phase-expressed protein 1, N-terminal

IPR026657 Proline/serine-rich coiled-coil protein 1/G2 and S phase-expressed protein 1
GlyGen

Q9D0P7 1 site, 1 O-linked glycan (1 site)

less

All nucleic 99

cDNA 99

Microarray probesets 5

less

MGI:1914808, MGI:2139859

Summaries

All 47

Developmental Gene Expression 4

Diseases 1

Gene Ontology 7

Phenotypes 10
Earliest

J:64940 Lo PK, et al., Identification of a novel mouse p53 target gene DDA3. Oncogene. 1999 Dec 16;18(54):7765-74
Latest

J:345389 Pan H, et al., Proline/serine-rich coiled-coil protein 1 inhibits macrophage inflammation and delays atherosclerotic progression by binding to Annexin A2. Clin Transl Med. 2023 Mar;13(3):e1220

TSS for Psrc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31246	Chr3:108291145-108291202 (+)	19 bp
Tssr31247	Chr3:108291203-108291214 (+)	54 bp
Tssr31248	Chr3:108291299-108291317 (+)	153 bp
Tssr31249	Chr3:108291321-108291333 (+)	172 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24