Il1rl2 MGI Mouse Gene Detail - MGI:1913107 - interleukin 1 receptor-like 2

Symbol

Il1rl2
Name

interleukin 1 receptor-like 2

Feature Type

protein coding gene
IDs

MGI:1913107
NCBI Gene: 107527
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:40363770-40406722 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 18.96 cM
Mapping Data

2 experiments

SNPs within 2kb

1394 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913107	protein coding gene	Chr1:40363697-40406722 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0015966	protein coding gene	Chr1:39110880-39154880 (+)
A/J	MGP_AJ_G0015950	protein coding gene	Chr1:38005494-38051293 (+)
AKR/J	MGP_AKRJ_G0015905	protein coding gene	Chr1:38496798-38537465 (+)
BALB/cJ	MGP_BALBcJ_G0015904	protein coding gene	Chr1:37664451-37708969 (+)
C3H/HeJ	MGP_C3HHeJ_G0015737	protein coding gene	Chr1:38782638-38832666 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016357	protein coding gene	Chr1:40716932-40760767 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014079	protein coding gene	Chr1:34938889-34983667 (+)
CAST/EiJ	MGP_CASTEiJ_G0015318	protein coding gene	Chr1:38686002-38729345 (+)
CBA/J	MGP_CBAJ_G0015709	protein coding gene	Chr1:41926527-41974461 (+)
DBA/2J	MGP_DBA2J_G0015810	protein coding gene	Chr1:37282883-37328723 (+)
FVB/NJ	MGP_FVBNJ_G0015812	protein coding gene	Chr1:36834532-36876931 (+)
LP/J	MGP_LPJ_G0015880	protein coding gene	Chr1:39445302-39489650 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015832	protein coding gene	Chr1:43930778-43974564 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016404	protein coding gene	Chr1:38644710-38686007 (+)
PWK/PhJ	MGP_PWKPhJ_G0015101	protein coding gene	Chr1:37104836-37146224 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014883	protein coding gene	Chr1:38583478-38649538 (+)
WSB/EiJ	MGP_WSBEiJ_G0015380	protein coding gene	Chr1:38615391-38655071 (+)

Human Ortholog

IL1RL2, interleukin 1 receptor like 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL1RL2, interleukin 1 receptor like 2
Synonyms

IL-1Rrp2, IL1R-rp2, IL1RRP2, IL-36R
Links

HGNC:5999

NCBI Gene ID: 8808

neXtProt AC: NX_Q9HB29

UniProt: Q9HB29
Chr Location

2q12.1; chr2:102186973-102243086 (+) GRCh38

MGI Vertebrate Homology

Il1rl2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IL1RL2
Gene Tree

Il1rl2

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Phenotype Summary

18 phenotypes from 2 alleles in 3 genetic backgrounds
2 phenotypes from multigenic genotypes
1 images
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

8
Targeted

2
Genomic Mutations

1 involving Il1rl2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

46 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a reporter allele are viable and overtly normal and have normal skin in an unchallenged context.

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All GO Annotations

18
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

36
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

53
RefSeq

12
UniProt

4
CCDS

CCDS14910.1

Ensembl

ENSMUSG00000070942 (Evidence)
NCBI Gene

107527

			Length	Strain/Species	Flank
genomic	ENSMUSG00000070942	Ensembl Gene Model \| MGI Sequence Detail	42953	C57BL/6J	± kb
transcript	ENSMUST00000095020	Ensembl \| MGI Sequence Detail	1950	Not Applicable
polypeptide	ENSMUSP00000092630	Ensembl \| MGI Sequence Detail	574	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000008995 interleukin-1 receptor-like 2

(term hierarchy)
EC

3.2.2.6
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR015621 Interleukin-1 receptor family

IPR004076 Interleukin-1 receptor type 1

IPR004074 Interleukin-1 receptor type I/II

IPR000157 Toll/interleukin-1 receptor homology (TIR) domain

IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily
GlyGen

Q9ERS7 9 sites, 1 N-linked glycan (1 site)

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All nucleic 36

cDNA 36

Microarray probesets 4

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MGI:2138277, MGI:2138611

Summaries

All 61

Developmental Gene Expression 2

Gene Ontology 11

Phenotypes 26
Earliest

J:64721 Born TL, et al., Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. DELINEATION OF A NEW CLASS OF IL-1R-RELATED PROTEINS BASED ON SIGNALING. J Biol Chem. 2000 Sep 29;275(39):29946-54
Latest

J:348359 Tongmuang N, et al., Floxed Il1rl2 Locus with mCherry Reporter Element Reveals Distinct Expression Patterns of the IL-36 Receptor in Barrier Tissues. Cells. 2024 May 6;13(9)

TSS for Il1rl2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6425	Chr1:40363730-40363783 (+)	-13 bp
Tssr6426	Chr1:40364746-40364769 (+)	988 bp
Tssr6427	Chr1:40395413-40395433 (+)	31,653 bp
Tssr64	Chr1:40398323-40398329 (+)	34,556 bp
Tssr6428	Chr1:40402989-40402998 (+)	39,224 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24