Pias3 MGI Mouse Gene Detail - MGI:1913126 - protein inhibitor of activated STAT 3

Symbol

Pias3
Name

protein inhibitor of activated STAT 3
Synonyms

Pias3L

Feature Type

protein coding gene
IDs

MGI:1913126
NCBI Gene: 229615
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr3:96603700-96613386 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 41.95 cM
Mapping Data

1 experiment

SNPs within 2kb

255 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913126	protein coding gene	Chr3:96603679-96613386 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027629	protein coding gene	Chr3:97588432-97598111 (+)
A/J	MGP_AJ_G0027591	protein coding gene	Chr3:94465662-94475318 (+)
AKR/J	MGP_AKRJ_G0027558	protein coding gene	Chr3:96702248-96711882 (+)
BALB/cJ	MGP_BALBcJ_G0027601	protein coding gene	Chr3:94277108-94287031 (+)
C3H/HeJ	MGP_C3HHeJ_G0027333	protein coding gene	Chr3:96999789-97011706 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028047	protein coding gene	Chr3:101145229-101156514 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025388	protein coding gene	Chr3:90741466-90751192 (+)
CAST/EiJ	MGP_CASTEiJ_G0026788	protein coding gene	Chr3:96256960-96267596 (+)
CBA/J	MGP_CBAJ_G0027308	protein coding gene	Chr3:104854427-104866181 (+)
DBA/2J	MGP_DBA2J_G0027451	protein coding gene	Chr3:93795108-93805395 (+)
FVB/NJ	MGP_FVBNJ_G0027420	protein coding gene	Chr3:91806280-91815938 (+)
LP/J	MGP_LPJ_G0027556	protein coding gene	Chr3:98869535-98879225 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027446	protein coding gene	Chr3:110937781-110948554 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028101	protein coding gene	Chr3:96309874-96320240 (+)
PWK/PhJ	MGP_PWKPhJ_G0026513	protein coding gene	Chr3:93629479-93639301 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026335	protein coding gene	Chr3:94609589-94619463 (+)
WSB/EiJ	MGP_WSBEiJ_G0026866	protein coding gene	Chr3:96761220-96771047 (+)

Human Ortholog

PIAS3, protein inhibitor of activated STAT 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PIAS3, protein inhibitor of activated STAT 3
Synonyms

ZMIZ5
Links

HGNC:16861

NCBI Gene ID: 10401

neXtProt AC: NX_Q9Y6X2

UniProt: Q9Y6X2
Chr Location

1q21.1; chr1:145848522-145859836 (-) GRCh38

MGI Vertebrate Homology

Pias3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PIAS3
Gene Tree

Pias3

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
2 phenotypes from multigenic genotypes
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

8
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Pias3
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

39 strains or lines available

Mice homozygous for a null allele display decreased susceptibility to induced abdominal aortic aneurysm formation.

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All GO Annotations

43
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

810
Tissues

71
cDNA Data

12
Literature Summary

13

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pias3

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All Sequences

85
RefSeq

16
UniProt

7
CCDS

CCDS17645.2, CCDS38559.1, CCDS51007.1

Ensembl

ENSMUSG00000028101 (Evidence)
NCBI Gene

229615

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028101	Ensembl Gene Model \| MGI Sequence Detail	9687	C57BL/6J	± kb
transcript	ENSMUST00000064900	Ensembl \| MGI Sequence Detail	2931	Not Applicable
polypeptide	ENSMUSP00000069259	Ensembl \| MGI Sequence Detail	628	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000003446 E3 SUMO-protein ligase PIAS3

(term hierarchy)
EC

2.3.2.-
InterPro Domains

IPR023321 PINIT domain

IPR038654 PINIT domain superfamily

IPR003034 SAP domain

IPR036361 SAP domain superfamily

IPR004181 Zinc finger, MIZ-type

IPR013083 Zinc finger, RING/FYVE/PHD-type
GlyGen

O54714 4 sites, 1 O-linked glycan (4 sites)

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All nucleic 19

Genomic 2

cDNA 14

Primer pair 3

Microarray probesets 5

Summaries

All 77

Developmental Gene Expression 13

Diseases 1

Gene Ontology 16

Phenotypes 15
Earliest

J:52872 Chung CD, et al., Specific inhibition of Stat3 signal transduction by PIAS3. Science. 1997 Dec 5;278(5344):1803-5
Latest

J:345238 Fu W, et al., Genetic deficiency of protein inhibitor of activated STAT3 suppresses experimental abdominal aortic aneurysms. Front Cardiovasc Med. 2023;10:1092555

TSS for Pias3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30753	Chr3:96603695-96603712 (+)	4 bp
Tssr30754	Chr3:96603716-96603793 (+)	55 bp
Tssr30755	Chr3:96604392-96604406 (+)	699 bp
Tssr30756	Chr3:96604416-96604481 (+)	749 bp
Tssr30757	Chr3:96606567-96606583 (+)	2,875 bp
Tssr30758	Chr3:96606618-96606620 (+)	2,919 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24