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Pias3 Gene Detail
Summary
  • Symbol
    Pias3
  • Name
    protein inhibitor of activated STAT 3
  • Synonyms
    Pias3L
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913126
    NCBI Gene: 229615
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:96603700-96613386 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 41.95 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    255 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913126
 protein coding gene Chr3:96603679-96613386 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027629
 protein coding gene Chr3:97588432-97598111 (+)
A/J MGP_AJ_G0027591
 protein coding gene Chr3:94465662-94475318 (+)
AKR/J MGP_AKRJ_G0027558
 protein coding gene Chr3:96702248-96711882 (+)
BALB/cJ MGP_BALBcJ_G0027601
 protein coding gene Chr3:94277108-94287031 (+)
C3H/HeJ MGP_C3HHeJ_G0027333
 protein coding gene Chr3:96999789-97011706 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028047
 protein coding gene Chr3:101145229-101156514 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025388
 protein coding gene Chr3:90741466-90751192 (+)
CAST/EiJ MGP_CASTEiJ_G0026788
 protein coding gene Chr3:96256960-96267596 (+)
CBA/J MGP_CBAJ_G0027308
 protein coding gene Chr3:104854427-104866181 (+)
DBA/2J MGP_DBA2J_G0027451
 protein coding gene Chr3:93795108-93805395 (+)
FVB/NJ MGP_FVBNJ_G0027420
 protein coding gene Chr3:91806280-91815938 (+)
LP/J MGP_LPJ_G0027556
 protein coding gene Chr3:98869535-98879225 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027446
 protein coding gene Chr3:110937781-110948554 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028101
 protein coding gene Chr3:96309874-96320240 (+)
PWK/PhJ MGP_PWKPhJ_G0026513
 protein coding gene Chr3:93629479-93639301 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026335
 protein coding gene Chr3:94609589-94619463 (+)
WSB/EiJ MGP_WSBEiJ_G0026866
 protein coding gene Chr3:96761220-96771047 (+)



Homology
more
  • Human Ortholog
    PIAS3, protein inhibitor of activated STAT 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIAS3, protein inhibitor of activated STAT 3
  • Synonyms
    ZMIZ5
  • Links
    NCBI Gene ID: 10401
    neXtProt AC: NX_Q9Y6X2
    UniProt: Q9Y6X2

  • Chr Location
    1q21.1; chr1:145848522-145859836 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    8
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Pias3
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    39 strains or lines available
Mice homozygous for a null allele display decreased susceptibility to induced abdominal aortic aneurysm formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    808
  • Tissues
    70
  • cDNA Data
    12
  • Literature Summary
    13
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028101 Ensembl Gene Model | MGI Sequence Detail 9687 C57BL/6J ±  kb
transcript ENSMUST00000064900 Ensembl | MGI Sequence Detail 2931 Not Applicable  
polypeptide ENSMUSP00000069259 Ensembl | MGI Sequence Detail 628 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    Genomic 2
    cDNA 14
    Primer pair 2

    Microarray probesets 5
References
more
  • Summaries
    All 77
    Developmental Gene Expression 13
    Diseases 1
    Gene Ontology 16
    Phenotypes 15
  • Earliest
    J:52872 Chung CD, et al., Specific inhibition of Stat3 signal transduction by PIAS3. Science. 1997 Dec 5;278(5344):1803-5
  • Latest
    J:345238 Fu W, et al., Genetic deficiency of protein inhibitor of activated STAT3 suppresses experimental abdominal aortic aneurysms. Front Cardiovasc Med. 2023;10:1092555
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory