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Alyref2 Gene Detail
Summary
  • Symbol
    Alyref2
  • Name
    Aly/REF export factor 2
  • Synonyms
    C130042O11Rik, Refbp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913144
    NCBI Gene: 56009
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:171331046-171332318 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 79.48 cM, cytoband H2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    222 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913144
 protein coding gene Chr1:171331046-171332324 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016764
 protein coding gene Chr1:177304220-177305491 (+)
A/J MGP_AJ_G0016744
 protein coding gene Chr1:170071765-170073032 (+)
AKR/J MGP_AKRJ_G0016710
 protein coding gene Chr1:175182967-175184236 (+)
BALB/cJ MGP_BALBcJ_G0016705
 protein coding gene Chr1:170566373-170567644 (+)
C3H/HeJ MGP_C3HHeJ_G0016528
 protein coding gene Chr1:175444392-175445663 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017166
 protein coding gene Chr1:183201894-183203157 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014874
 protein coding gene Chr1:161760332-161761646 (+)
CAST/EiJ MGP_CASTEiJ_G0016109
 protein coding gene Chr1:175051698-175052962 (+)
CBA/J MGP_CBAJ_G0016503
 protein coding gene Chr1:189717501-189718767 (+)
DBA/2J MGP_DBA2J_G0016610
 protein coding gene Chr1:168914238-168915798 (+)
FVB/NJ MGP_FVBNJ_G0016606
 protein coding gene Chr1:167269422-167270691 (+)
LP/J MGP_LPJ_G0016681
 protein coding gene Chr1:178407135-178408406 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016633
 protein coding gene Chr1:196980082-196981353 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017203
 protein coding gene Chr1:175039791-175041057 (+)
PWK/PhJ MGP_PWKPhJ_G0015895
 protein coding gene Chr1:168148501-168149767 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015679
 protein coding gene Chr1:173834496-173835844 (+)
WSB/EiJ MGP_WSBEiJ_G0016171
 protein coding gene Chr1:175159399-175160666 (+)



Homology
more
  • Human Ortholog
    ALYREF, Aly/REF export factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALYREF, Aly/REF export factor
  • Synonyms
    ALY, ALY/REF, BEF, REF, THOC4
  • Links
    NCBI Gene ID: 10189
    neXtProt AC: NX_Q86V81
    UniProt: Q86V81

  • Chr Location
    17q25.3; chr17:81887835-81891587 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    732
  • Tissues
    26
  • cDNA Data
    5
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 56009 NCBI Gene Model | MGI Sequence Detail 1273 C57BL/6J ±  kb
transcript NM_019484 RefSeq | MGI Sequence Detail 1273 C57BL/6  
polypeptide Q9JJW6 UniProt | EBI | MGI Sequence Detail 218 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    Genomic 1
    cDNA 5
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2443343
References
more
  • Summaries
    All 28
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 2
  • Earliest
    J:65157 Stutz F, et al., REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export. RNA. 2000 Apr;6(4):638-50
  • Latest
    J:326286 Tunnicliffe RB, et al., Competitive and cooperative interactions mediate RNA transfer from herpesvirus saimiri ORF57 to the mammalian export adaptor ALYREF. PLoS Pathog. 2014 Feb;10(2):e1003907
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory