Lamtor4 MGI Mouse Gene Detail - MGI:1913346 - late endosomal/lysosomal adaptor, MAPK and MTOR activator 4

Symbol

Lamtor4
Name

late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
Synonyms

0910001L09Rik

Feature Type

protein coding gene
IDs

MGI:1913346
NCBI Gene: 66096
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr5:138253744-138257657 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 77.00 cM
Mapping Data

2 experiments

SNPs within 2kb

177 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913346	protein coding gene	Chr5:138253744-138257660 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030263	protein coding gene	Chr5:143105281-143109191 (+)
A/J	MGP_AJ_G0030231	protein coding gene	Chr5:136984535-136988444 (+)
AKR/J	MGP_AKRJ_G0030163	protein coding gene	Chr5:141354084-141360488 (+)
BALB/cJ	MGP_BALBcJ_G0030245	protein coding gene	Chr5:138318961-138322878 (+)
C3H/HeJ	MGP_C3HHeJ_G0029958	protein coding gene	Chr5:142080227-142084138 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030692	protein coding gene	Chr5:148403356-148407273 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027909	protein coding gene	Chr5:131003585-131007407 (+)
CAST/EiJ	MGP_CASTEiJ_G0029364	protein coding gene	Chr5:141416111-141420072 (+)
CBA/J	MGP_CBAJ_G0029929	protein coding gene	Chr5:154455129-154459091 (+)
DBA/2J	MGP_DBA2J_G0030077	protein coding gene	Chr5:136878040-136882004 (+)
FVB/NJ	MGP_FVBNJ_G0030035	protein coding gene	Chr5:135980374-135984292 (+)
LP/J	MGP_LPJ_G0030166	protein coding gene	Chr5:143652315-143656225 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030066	protein coding gene	Chr5:157207404-157211315 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030733	protein coding gene	Chr5:141161798-141165714 (+)
PWK/PhJ	MGP_PWKPhJ_G0029078	protein coding gene	Chr5:135844489-135848514 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028913	protein coding gene	Chr5:138766040-138769940 (+)
WSB/EiJ	MGP_WSBEiJ_G0029439	protein coding gene	Chr5:141848613-141853802 (+)

Human Ortholog

LAMTOR4, late endosomal/lysosomal adaptor, MAPK and MTOR activator 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LAMTOR4, late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
Synonyms

C7orf59
Links

HGNC:33772

NCBI Gene ID: 389541

neXtProt AC: NX_Q0VGL1

UniProt: Q0VGL1
Chr Location

7q22.1; chr7:100148912-100155944 (+) GRCh38

MGI Vertebrate Homology

Lamtor4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LAMTOR4
Gene Tree

Lamtor4

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Gene trapped

2
Targeted

1
Incidental Mutations

APF
Find Mice (IMSR)

7 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

33
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

8
cDNA Data

67
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lamtor4

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All Sequences

36
RefSeq

2
UniProt

1
CCDS

CCDS39342.1

Ensembl

ENSMUSG00000050552 (Evidence)
NCBI Gene

66096

			Length	Strain/Species	Flank
genomic	66096	NCBI Gene Model \| MGI Sequence Detail	3914	C57BL/6J	± kb
transcript	NM_001081108	RefSeq \| MGI Sequence Detail	900	C57BL/6
polypeptide	Q8CF66	UniProt \| EBI \| MGI Sequence Detail	99	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000039137 ragulator complex protein LAMTOR4

(term hierarchy)
InterPro Domains

IPR034601 Ragulator complex protein LAMTOR4

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All nucleic 68

cDNA 68

Microarray probesets 3

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MGI:2141100

Summaries

All 36

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lamtor4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr49434	Chr5:138253976-138253987 (+)	238 bp
Tssr49435	Chr5:138253989-138254050 (+)	276 bp
Tssr49436	Chr5:138254117-138254128 (+)	379 bp
Tssr49437	Chr5:138254329-138254385 (+)	613 bp
Tssr49438	Chr5:138254386-138254397 (+)	648 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24