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Fkbp11 Gene Detail
Summary
  • Symbol
    Fkbp11
  • Name
    FK506 binding protein 11
  • Synonyms
    1110002O23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913370
    NCBI Gene: 66120
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:98622249-98626079 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 54.65 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    169 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913370
 protein coding gene Chr15:98622247-98626079 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022308
 protein coding gene Chr15:100474566-100480541 (-)
A/J MGP_AJ_G0022266
 protein coding gene Chr15:96512035-96516283 (-)
AKR/J MGP_AKRJ_G0022241
 protein coding gene Chr15:99483568-99489009 (-)
BALB/cJ MGP_BALBcJ_G0022273
 protein coding gene Chr15:96705347-96709172 (-)
C3H/HeJ MGP_C3HHeJ_G0022041
 protein coding gene Chr15:99530996-99536053 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022718
 protein coding gene Chr15:104198871-104202767 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020243
 protein coding gene Chr15:92426851-92430928 (-)
CAST/EiJ MGP_CASTEiJ_G0021564
 protein coding gene Chr15:100376293-100380119 (-)
CBA/J MGP_CBAJ_G0022010
 protein coding gene Chr15:107738693-107742901 (-)
DBA/2J MGP_DBA2J_G0022136
 protein coding gene Chr15:95954354-95958608 (-)
FVB/NJ MGP_FVBNJ_G0022116
 protein coding gene Chr15:94932572-94936963 (-)
LP/J MGP_LPJ_G0022208
 protein coding gene Chr15:100627135-100631714 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022136
 protein coding gene Chr15:111754914-111758739 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022733
 protein coding gene Chr15:99564617-99568491 (-)
PWK/PhJ MGP_PWKPhJ_G0021305
 protein coding gene Chr15:96073164-96077438 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021140
 protein coding gene Chr15:99409119-99413282 (-)
WSB/EiJ MGP_WSBEiJ_G0021614
 protein coding gene Chr15:100108845-100113090 (-)



Homology
more
  • Human Ortholog
    FKBP11, FKBP prolyl isomerase 11
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FKBP11, FKBP prolyl isomerase 11
  • Synonyms
    FKBP19
  • Links
    NCBI Gene ID: 51303
    neXtProt AC: NX_Q9NYL4
    UniProt: Q9NYL4

  • Chr Location
    12q13.12; chr12:48921518-48939034 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions of this gene display increased antibody response to antibody challenge and increased inflammatory responses. Measurements of bone density are also increased.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    847
  • Tissues
    17
  • cDNA Data
    53
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66120 NCBI Gene Model | MGI Sequence Detail 3831 C57BL/6J ±  kb
    transcript NM_024169 RefSeq | MGI Sequence Detail 736 C57BL/6  
    polypeptide Q9D1M7 UniProt | EBI | MGI Sequence Detail 201 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000007533 peptidyl-prolyl cis-trans isomerase FKBP11
      (term hierarchy)
    • EC
      5.2.1.8
    • InterPro Domains
      IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain
      IPR046357 Peptidyl-prolyl cis-trans isomerase domain superfamily
      IPR044609 Peptidyl-prolyl cis-trans isomerase FKBP2/11
    • GlyGen
      Q9D1M7 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 53
      cDNA 53

      Microarray probesets 6
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 5
      Phenotypes 31
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory