Prorp MGI Mouse Gene Detail - MGI:1913382 - protein only RNase P catalytic subunit

Symbol

Prorp
Name

protein only RNase P catalytic subunit
Synonyms

1110008L16Rik, Mrpp3

Feature Type

protein coding gene
IDs

MGI:1913382
NCBI Gene: 66132
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr12:55349422-55429276 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 23.91 cM, cytoband C1
Mapping Data

3 experiments

SNPs within 2kb

2235 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913382	protein coding gene	Chr12:55346362-55429318 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019747	protein coding gene	Chr12:54336720-54424574 (+)
A/J	MGP_AJ_G0019706	protein coding gene	Chr12:52375812-52460671 (+)
AKR/J	MGP_AKRJ_G0019681	protein coding gene	Chr12:54042607-54131871 (+)
BALB/cJ	MGP_BALBcJ_G0019686	protein coding gene	Chr12:52747698-52835036 (+)
C3H/HeJ	MGP_C3HHeJ_G0019491	protein coding gene	Chr12:54087407-54189288 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020138	protein coding gene	Chr12:55960295-56050989 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017758	protein coding gene	Chr12:50487154-50973246 (+)
CAST/EiJ	MGP_CASTEiJ_G0019043	protein coding gene	Chr12:48941769-49040902 (+)
CBA/J	MGP_CBAJ_G0019460	protein coding gene	Chr12:57919377-58016050 (+)
DBA/2J	MGP_DBA2J_G0019576	protein coding gene	Chr12:52292013-52388469 (+)
FVB/NJ	MGP_FVBNJ_G0019564	protein coding gene	Chr12:51589910-51684755 (+)
LP/J	MGP_LPJ_G0019648	protein coding gene	Chr12:54255398-54419993 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019602	protein coding gene	Chr12:59493295-59600046 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020172	protein coding gene	Chr12:53487113-53571359 (+)
PWK/PhJ	MGP_PWKPhJ_G0018810	protein coding gene	Chr12:46646703-46733688 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018603	protein coding gene	Chr12:47878118-47975358 (+)
WSB/EiJ	MGP_WSBEiJ_G0019094	protein coding gene	Chr12:53987892-54081585 (+)

Human Ortholog

PRORP, protein only RNase P catalytic subunit

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRORP, protein only RNase P catalytic subunit
Synonyms

COXPD54, KIAA0391, MRPP3
Links

HGNC:19958

NCBI Gene ID: 9692

neXtProt AC: NX_O15091

UniProt: O15091
Chr Location

14q13.2; chr14:35121839-35277622 (+) GRCh38

MGI Vertebrate Homology

Prorp stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PRORP
Gene Tree

Prorp

Diseases

1 with human PRORP associations

				Human Disease	Mouse Models
				combined oxidative phosphorylation deficiency 54 IDs combined oxidative phosphorylation deficiency 54 DOID:0070427 OMIM:619737

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

69
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

65
Targeted

2
Genomic Mutations

1 involving Prorp
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

46 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit embryonic lethality. Mice homozygous for a conditional allele activated in skeletal and cardiac muscle exhibit premature death associated with cardiac myopathy and impaired mitochondrial function due to decreased tRNA 5' end processing.

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All GO Annotations

16
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

35

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase prorp

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All Sequences

52
RefSeq

2
UniProt

4
CCDS

CCDS49068.1

Ensembl

ENSMUSG00000021023 (Evidence)
NCBI Gene

66132

			Length	Strain/Species	Flank
genomic	66132	NCBI Gene Model \| MGI Sequence Detail	79855	C57BL/6J	± kb
transcript	NM_025373	RefSeq \| MGI Sequence Detail	3117	C57BL/6
polypeptide	Q8JZY4	UniProt \| EBI \| MGI Sequence Detail	584	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000060169 mitochondrial ribonuclease P catalytic subunit

(term hierarchy)
EC

3.1.26.5
InterPro Domains

IPR033495 Mitochondrial ribonuclease P catalytic subunit, PIN domain

IPR031595 Protein-only RNase P, C-terminal

IPR011990 Tetratricopeptide-like helical domain superfamily

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All nucleic 36

cDNA 36

Microarray probesets 3

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MGI:6295976

Summaries

All 36

Gene Ontology 6

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:249591 Kuznetsova I, et al., Simultaneous processing and degradation of mitochondrial RNAs revealed by circularized RNA sequencing. Nucleic Acids Res. 2017 May 19;45(9):5487-5500

TSS for Prorp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113481	Chr12:55349529-55349569 (+)	127 bp
Tssr113482	Chr12:55349609-55349649 (+)	207 bp
Tssr113483	Chr12:55350026-55350069 (+)	626 bp
Tssr113484	Chr12:55408133-55408176 (+)	58,733 bp
Tssr113485	Chr12:55423924-55423943 (+)	74,512 bp
Tssr113486	Chr12:55423945-55423996 (+)	74,549 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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