Ska2 MGI Mouse Gene Detail - MGI:1913390 - spindle and kinetochore associated complex subunit 2

Symbol

Ska2
Name

spindle and kinetochore associated complex subunit 2
Synonyms

1110001A07Rik, Fam33a

Feature Type

protein coding gene
IDs

MGI:1913390
NCBI Gene: 66140
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:87000087-87013800 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 51.91 cM
Mapping Data

2 experiments

SNPs within 2kb

60 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913390	protein coding gene	Chr11:87000060-87015461 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018900	protein coding gene	Chr11:88686211-88702258 (+)
A/J	MGP_AJ_G0018867	protein coding gene	Chr11:85279953-85295331 (+)
AKR/J	MGP_AKRJ_G0018837	protein coding gene	Chr11:87824944-87839998 (+)
BALB/cJ	MGP_BALBcJ_G0018840	protein coding gene	Chr11:85664902-85680214 (+)
C3H/HeJ	MGP_C3HHeJ_G0018654	protein coding gene	Chr11:87849425-87865795 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019292	protein coding gene	Chr11:91359285-91374652 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016925	protein coding gene	Chr11:82307909-82323945 (+)
CAST/EiJ	MGP_CASTEiJ_G0018209	protein coding gene	Chr11:88559858-88575940 (+)
CBA/J	MGP_CBAJ_G0018625	protein coding gene	Chr11:95203399-95218963 (+)
DBA/2J	MGP_DBA2J_G0018733	protein coding gene	Chr11:84839977-84855376 (+)
FVB/NJ	MGP_FVBNJ_G0018722	protein coding gene	Chr11:84345957-84361531 (+)
LP/J	MGP_LPJ_G0018803	protein coding gene	Chr11:89189630-89205730 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018749	protein coding gene	Chr11:95290487-95305581 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019332	protein coding gene	Chr11:88068795-88083917 (+)
PWK/PhJ	MGP_PWKPhJ_G0017979	protein coding gene	Chr11:85653511-85669019 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017771	protein coding gene	Chr11:87636092-87651547 (+)
WSB/EiJ	MGP_WSBEiJ_G0018260	protein coding gene	Chr11:87946254-87961625 (+)

Human Ortholog

SKA2, spindle and kinetochore associated complex subunit 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SKA2, spindle and kinetochore associated complex subunit 2
Synonyms

FAM33A
Links

HGNC:28006

NCBI Gene ID: 348235

neXtProt AC: NX_Q8WVK7

UniProt: Q8WVK7
Chr Location

17q22; chr17:59109857-59155260 (-) GRCh38

MGI Vertebrate Homology

Ska2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SKA2
Gene Tree

Ska2

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Phenotype Summary

18 phenotypes from 1 allele in 1 genetic background
1 images
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

58
Chemically induced (other)

1
Gene trapped

53
Targeted

4
Genomic Mutations

2 involving Ska2
Incidental Mutations

APF
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete lethality prior to organogenesis.

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All GO Annotations

27
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

849
Tissues

59
cDNA Data

86
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ska2

ZFIN ska2

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All Sequences

45
RefSeq

2
UniProt

2
CCDS

CCDS25209.1

Ensembl

ENSMUSG00000020492 (Evidence)
NCBI Gene

66140

			Length	Strain/Species	Flank
genomic	66140	NCBI Gene Model \| MGI Sequence Detail	13714	C57BL/6J	± kb
transcript	NM_025377	RefSeq \| MGI Sequence Detail	1349	C57BL/6
polypeptide	Q9CR46	UniProt \| EBI \| MGI Sequence Detail	120	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000029757 spindle and kinetochore-associated protein 2

(term hierarchy)
InterPro Domains

IPR042091 Ska2, N-terminal

IPR026762 Spindle and kinetochore-associated protein 2
GlyGen

Q9CR46 1 site, 1 O-linked glycan (1 site)

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All nucleic 87

cDNA 86

Primer pair 1

Microarray probesets 5

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MGI:2144644

Summaries

All 50

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 20
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ska2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103905	Chr11:87000007-87000021 (+)	-73 bp
Tssr103906	Chr11:87000047-87000065 (+)	-31 bp
Tssr103907	Chr11:87000078-87000100 (+)	2 bp
Tssr103908	Chr11:87000386-87000409 (+)	311 bp
Tssr103910	Chr11:87012406-87012409 (+)	12,321 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24