Cox7b MGI Mouse Gene Detail - MGI:1913392 - cytochrome c oxidase subunit 7B

Symbol

Cox7b
Name

cytochrome c oxidase subunit 7B
Synonyms

1110004F07Rik

Feature Type

protein coding gene
IDs

MGI:1913392
NCBI Gene: 66142
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

ChrX:105059306-105066056 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 47.36 cM, cytoband C3
Mapping Data

2 experiments

SNPs within 2kb

227 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913392	protein coding gene	ChrX:105059306-105066056 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0036001	protein coding gene	ChrX:102798756-102808847 (+)
A/J	MGP_AJ_G0035980	protein coding gene	ChrX:102567397-102574060 (+)
AKR/J	MGP_AKRJ_G0035899	protein coding gene	ChrX:105858563-105865221 (+)
BALB/cJ	MGP_BALBcJ_G0035970	protein coding gene	ChrX:101410138-101417060 (+)
C3H/HeJ	MGP_C3HHeJ_G0035677	protein coding gene	ChrX:103236011-103242704 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036497	protein coding gene	ChrX:105732556-105739238 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033325	protein coding gene	ChrX:100040458-100047183 (+)
CAST/EiJ	MGP_CASTEiJ_G0034964	protein coding gene	ChrX:87382992-87389521 (+)
CBA/J	MGP_CBAJ_G0035652	protein coding gene	ChrX:109052719-109061253 (+)
DBA/2J	MGP_DBA2J_G0035806	protein coding gene	ChrX:101860027-101866860 (+)
FVB/NJ	MGP_FVBNJ_G0035747	protein coding gene	ChrX:101173690-101180345 (+)
LP/J	MGP_LPJ_G0035899	protein coding gene	ChrX:103753562-103760254 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035779	protein coding gene	ChrX:113736865-113746038 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036523	protein coding gene	ChrX:102434277-102440997 (+)
PWK/PhJ	MGP_PWKPhJ_G0034660	protein coding gene	ChrX:84911633-84918511 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034489	protein coding gene	ChrX:88117604-88124018 (+)
WSB/EiJ	MGP_WSBEiJ_G0035102	protein coding gene	ChrX:101136731-101143432 (+)

Human Ortholog

COX7B, cytochrome c oxidase subunit 7B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

COX7B, cytochrome c oxidase subunit 7B
Synonyms

APLCC, LSDMCA2
Links

HGNC:2291

NCBI Gene ID: 1349

neXtProt AC: NX_P24311

UniProt: P24311
Chr Location

Xq21.1; chrX:77899440-77907376 (+) GRCh38

MGI Vertebrate Homology

Cox7b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: COX7B
Gene Tree

Cox7b

Diseases

1 with human COX7B associations

				Human Disease	Mouse Models
				linear skin defects with multiple congenital anomalies 2 IDs linear skin defects with multiple congenital anomalies 2 DOID:0111877 OMIM:300887

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
3 images
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

68
Gene trapped

68
Incidental Mutations

APF
Find Mice (IMSR)

7 strains or lines available

Male chimeras hemizygous for a gene trapped allele appear normal at E6.5. However, no embryos fully derived from mutant ES cells can be generated.

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All GO Annotations

10
GO References

7

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

812
Tissues

101
cDNA Data

225
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cox7b

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All Sequences

34
RefSeq

2
UniProt

2
CCDS

CCDS41096.1

Ensembl

ENSMUSG00000031231 (Evidence)
NCBI Gene

66142

			Length	Strain/Species	Flank
genomic	66142	NCBI Gene Model \| MGI Sequence Detail	6751	C57BL/6J	± kb
transcript	NM_025379	RefSeq \| MGI Sequence Detail	1176	Not Specified
polypeptide	P56393	UniProt \| EBI \| MGI Sequence Detail	80	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005789 cytochrome c oxidase subunit 7B, mitochondrial

(term hierarchy)
PDB

7O37, 7O3C, 7O3E, 8PW5, 8PW6, 8PW7
InterPro Domains

IPR008433 Cytochrome C oxidase, subunit VIIB

IPR023272 Cytochrome C oxidase, subunit VIIB domain superfamily
GlyGen

P56393 1 site, 1 O-linked glycan (1 site)

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All nucleic 228

cDNA 225

Primer pair 3

Microarray probesets 2

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MGI:2138693

Summaries

All 41

Developmental Gene Expression 8

Gene Ontology 7

Phenotypes 6
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:355679 Vercellino I, et al., SCAF1 drives the compositional diversity of mammalian respirasomes. Nat Struct Mol Biol. 2024 Jul;31(7):1061-1071

TSS for Cox7b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr161755	ChrX:105059305-105059365 (+)	29 bp
Tssr161756	ChrX:105059370-105059372 (+)	65 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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