Dnajc15 MGI Mouse Gene Detail - MGI:1913398 - DnaJ heat shock protein family (Hsp40) member C15

Symbol

Dnajc15
Name

DnaJ heat shock protein family (Hsp40) member C15
Synonyms

1110003P16Rik, Dnajd1, MCJ

Feature Type

protein coding gene
IDs

MGI:1913398
NCBI Gene: 66148
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr14:78063657-78112357 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 41.04 cM, cytoband D3
Mapping Data

2 experiments

SNPs within 2kb

1220 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913398	protein coding gene	Chr14:78058121-78112565 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021586	protein coding gene	Chr14:72840688-72896376 (-)
A/J	MGP_AJ_G0021544	protein coding gene	Chr14:71111355-71159690 (-)
AKR/J	MGP_AKRJ_G0021521	protein coding gene	Chr14:73220752-73270328 (-)
BALB/cJ	MGP_BALBcJ_G0021551	protein coding gene	Chr14:70915056-70963216 (-)
C3H/HeJ	MGP_C3HHeJ_G0021328	protein coding gene	Chr14:72933867-72983220 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021991	protein coding gene	Chr14:75962431-76039807 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019529	protein coding gene	Chr14:68683937-68737711 (-)
CAST/EiJ	MGP_CASTEiJ_G0020845	protein coding gene	Chr14:69707643-69763304 (-)
CBA/J	MGP_CBAJ_G0021296	protein coding gene	Chr14:78415647-78468315 (-)
DBA/2J	MGP_DBA2J_G0021419	protein coding gene	Chr14:70497331-70546047 (-)
FVB/NJ	MGP_FVBNJ_G0021397	protein coding gene	Chr14:69840012-69888070 (-)
LP/J	MGP_LPJ_G0021489	protein coding gene	Chr14:73965292-74020278 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021424	protein coding gene	Chr14:77067306-77125874 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022014	protein coding gene	Chr14:72512401-72562751 (-)
PWK/PhJ	MGP_PWKPhJ_G0020588	protein coding gene	Chr14:67272398-67325488 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020425	protein coding gene	Chr14:68477617-68535707 (-)
WSB/EiJ	MGP_WSBEiJ_G0020898	protein coding gene	Chr14:72842836-72893194 (-)

Human Ortholog

DNAJC15, DnaJ heat shock protein family (Hsp40) member C15

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNAJC15, DnaJ heat shock protein family (Hsp40) member C15
Synonyms

DNAJD1, HSD18, MCJ
Links

HGNC:20325

NCBI Gene ID: 29103

neXtProt AC: NX_Q9Y5T4

UniProt: Q9Y5T4
Chr Location

13q14.11; chr13:43023203-43114213 (+) GRCh38

MGI Vertebrate Homology

Dnajc15 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DNAJC15
Gene Tree

Dnajc15

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Phenotype Summary

17 phenotypes from 2 alleles in 2 genetic backgrounds
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

18
Targeted

3
Genomic Mutations

1 involving Dnajc15
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased mitochondrial activity that results in rapid metabolism in fasted mice or mice fed a high fat diet.

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All GO Annotations

14
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

789
Tissues

49
cDNA Data

81
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dnajc15

ZFIN dnajc15

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All Sequences

36
RefSeq

2
UniProt

2
CCDS

CCDS27292.1

Ensembl

ENSMUSG00000022013 (Evidence)
NCBI Gene

66148

			Length	Strain/Species	Flank
genomic	66148	NCBI Gene Model \| MGI Sequence Detail	48701	C57BL/6J	± kb
transcript	NM_025384	RefSeq \| MGI Sequence Detail	671	C57BL/6
polypeptide	Q78YY6	UniProt \| EBI \| MGI Sequence Detail	149	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000029418 DnaJ homolog subfamily C member 15

(term hierarchy)
InterPro Domains

IPR036869 Chaperone J-domain superfamily

IPR001623 DnaJ domain

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All nucleic 81

cDNA 81

Microarray probesets 2

Summaries

All 53

Developmental Gene Expression 6

Gene Ontology 4

Phenotypes 27
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:349002 Wu MH, et al., Deleting the mitochondrial respiration negative regulator MCJ enhances the efficacy of CD8(+) T cell adoptive therapies in pre-clinical studies. Nat Commun. 2024 May 24;15(1):4444

TSS for Dnajc15:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr129851	Chr14:78112567-78112574 (-)	-214 bp
Tssr129850	Chr14:78112533-78112548 (-)	-184 bp
Tssr129849	Chr14:78112493-78112507 (-)	-143 bp
Tssr129848	Chr14:78112327-78112381 (-)	3 bp
Tssr129847	Chr14:78112306-78112317 (-)	45 bp
Tssr129846	Chr14:78112285-78112296 (-)	66 bp
Tssr129845	Chr14:78098756-78098783 (-)	13,587 bp
Tssr129844	Chr14:78098728-78098736 (-)	13,625 bp
Tssr129843	Chr14:78094406-78094431 (-)	17,938 bp
Tssr129842	Chr14:78093734-78093738 (-)	18,621 bp
Tssr129841	Chr14:78081795-78081800 (-)	30,559 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24