Bola2 MGI Mouse Gene Detail - MGI:1913412

Symbol

Bola2
Name

bolA family member 2
Synonyms

1110025L05Rik

Feature Type

protein coding gene
IDs

MGI:1913412
NCBI Gene: 66162
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr7:126295172-126295865 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 69.25 cM
Mapping Data

1 experiment

SNPs within 2kb

122 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913412	protein coding gene	Chr7:126294573-126298970 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032993	protein coding gene	Chr7:130982565-130986984 (+)
A/J	MGP_AJ_G0032976	protein coding gene	Chr7:127518909-127523305 (+)
AKR/J	MGP_AKRJ_G0032908	protein coding gene	Chr7:130751339-130755742 (+)
BALB/cJ	MGP_BALBcJ_G0032981	protein coding gene	Chr7:127174824-127179227 (+)
C3H/HeJ	MGP_C3HHeJ_G0032691	protein coding gene	Chr7:130684253-130688632 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033487	protein coding gene	Chr7:136083784-136088181 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030459	protein coding gene	Chr7:128711015-128715272 (+)
CAST/EiJ	MGP_CASTEiJ_G0032020	protein coding gene	Chr7:122464993-122469394 (+)
CBA/J	MGP_CBAJ_G0032664	protein coding gene	Chr7:140662802-140667199 (+)
DBA/2J	MGP_DBA2J_G0032816	protein coding gene	Chr7:125494850-125499247 (+)
FVB/NJ	MGP_FVBNJ_G0032769	protein coding gene	Chr7:125341353-125345602 (+)
LP/J	MGP_LPJ_G0032910	protein coding gene	Chr7:132450583-132454950 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032801	protein coding gene	Chr7:141845053-141849438 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033506	protein coding gene	Chr7:129759403-129763799 (+)
PWK/PhJ	MGP_PWKPhJ_G0031727	protein coding gene	Chr7:118484445-118488842 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031573	protein coding gene	Chr7:116602522-116606780 (+)
WSB/EiJ	MGP_WSBEiJ_G0032132	protein coding gene	Chr7:130733566-130744443 (+)

Human Ortholog

BOLA2, bolA family member 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BOLA2, bolA family member 2
Synonyms

BOLA2A, BOLA2B, My016
Links

HGNC:29488

NCBI Gene ID: 552900

neXtProt AC: NX_Q9H3K6

UniProt: Q9H3K6
Chr Location

16p11.2

Human Ortholog

BOLA2B, bolA family member 2B
Synonyms

BOLA2
Links

HGNC:32479

NCBI Gene ID: 654483

neXtProt AC: NX_Q9H3K6

UniProt: Q9H3K6
Chr Location

16p11.2; chr16:30192932-30194306 (-) GRCh38

MGI Vertebrate Homology

Bola2 stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BOLA2, BOLA2B
Protein SuperFamily

BolA
Gene Tree

Bola2

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References

2 with disease annotations

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
44 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Gene trapped

4
Targeted

6
Genomic Mutations

4 involving Bola2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

5 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

12
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

50

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase bola2

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All Sequences

39
RefSeq

2
UniProt

1
CCDS

CCDS40129.1

Ensembl

ENSMUSG00000047721 (Evidence)
NCBI Gene

66162

			Length	Strain/Species	Flank
genomic	66162	NCBI Gene Model \| MGI Sequence Detail	694	C57BL/6J	± kb
transcript	NM_175103	RefSeq \| MGI Sequence Detail	337	C57BL/6
polypeptide	Q8BGS2	UniProt \| EBI \| MGI Sequence Detail	86	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000004787 BolA-like protein 2

(term hierarchy)
PDB

1V9J
InterPro Domains

IPR045115 BolA-like protein 2

IPR036065 BolA-like superfamily

IPR002634 BolA protein

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All nucleic 50

cDNA 50

Microarray probesets 2

Summaries

All 65

Diseases 2

Gene Ontology 4

Phenotypes 44
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:349484 Henis M, et al., The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation. Sci Adv. 2024 Apr 12;10(15):eadf7001

TSS for Bola2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr69055	Chr7:126294527-126294603 (+)	-607 bp
Tssr69056	Chr7:126295114-126295181 (+)	-24 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24