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P3h4 Gene Detail
Summary
  • Symbol
    P3h4
  • Name
    prolyl 3-hydroxylase family member 4 (non-enzymatic)
  • Synonyms
    1110036O03Rik, Leprel4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913430
    NCBI Gene: 66180
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100299293-100305542 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 63.47 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    203 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913430
 protein coding gene Chr11:100299282-100305662 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019153
 protein coding gene Chr11:103166775-103173170 (-)
A/J MGP_AJ_G0019121
 protein coding gene Chr11:98856250-98862639 (-)
AKR/J MGP_AKRJ_G0019090
 protein coding gene Chr11:101903425-101909791 (-)
BALB/cJ MGP_BALBcJ_G0019095
 protein coding gene Chr11:99336669-99343064 (-)
C3H/HeJ MGP_C3HHeJ_G0018904
 protein coding gene Chr11:102100645-102107078 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019544
 protein coding gene Chr11:106372475-106378855 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017170
 protein coding gene Chr11:96273422-96280103 (-)
CAST/EiJ MGP_CASTEiJ_G0018458
 protein coding gene Chr11:103071883-103078974 (-)
CBA/J MGP_CBAJ_G0018873
 protein coding gene Chr11:110798568-110804963 (-)
DBA/2J MGP_DBA2J_G0018985
 protein coding gene Chr11:98394898-98401293 (-)
FVB/NJ MGP_FVBNJ_G0018975
 protein coding gene Chr11:97925779-97932485 (-)
LP/J MGP_LPJ_G0019054
 protein coding gene Chr11:103710794-103717189 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019006
 protein coding gene Chr11:110411139-110417517 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019582
 protein coding gene Chr11:102247447-102253842 (-)
PWK/PhJ MGP_PWKPhJ_G0018221
 protein coding gene Chr11:99432045-99438482 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018013
 protein coding gene Chr11:101963763-101970200 (-)
WSB/EiJ MGP_WSBEiJ_G0018507
 protein coding gene Chr11:102232200-102238586 (-)



Homology
more
  • Human Ortholog
    P3H4, prolyl 3-hydroxylase family member 4 (inactive)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    P3H4, prolyl 3-hydroxylase family member 4 (inactive)
  • Synonyms
    LEPREL4, NO55, NOL55, SC65
  • Links
    NCBI Gene ID: 10609
    neXtProt AC: NX_Q92791
    UniProt: Q92791

  • Chr Location
    17q21.2; chr17:41801947-41812604 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased trabecular volume, compact bone thickness, skin tensile strength and muscle below the hypodermis with decreased cutaneous collagen fiber density.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    886
  • Tissues
    117
  • cDNA Data
    52
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66180 NCBI Gene Model | MGI Sequence Detail 6250 C57BL/6J ±  kb
    transcript NM_001378981 RefSeq | MGI Sequence Detail 2146 C57BL/6  
    polypeptide Q8K2B0 UniProt | EBI | MGI Sequence Detail 443 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000014481 endoplasmic reticulum protein SC65
      (term hierarchy)
    • InterPro Domains
      IPR052284 Collagen-modifying leprecan protein
      IPR011990 Tetratricopeptide-like helical domain superfamily
    • GlyGen
      Q8K2B0 2 sites, 3 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 54
      cDNA 52
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2144143
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:50799 Liu P, et al., Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11. Genetics. 1998 Nov;150(3):1155-68
    • Latest
      J:251120 Klank RL, et al., Biphasic Dependence of Glioma Survival and Cell Migration on CD44 Expression Level. Cell Rep. 2017 Jan 3;18(1):23-31
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory