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Thoc7 Gene Detail
Summary
  • Symbol
    Thoc7
  • Name
    THO complex 7
  • Synonyms
    1500006O09Rik, 9230101K24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913481
    NCBI Gene: 66231
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:8507911-8520751 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 7.08 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    458 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913481
 protein coding gene Chr14:8507911-8520751 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021004
 protein coding gene Chr14:6471383-6485809 (-)
A/J MGP_AJ_G0020952
 protein coding gene Chr14:6320874-6333950 (-)
AKR/J MGP_AKRJ_G0020929
 protein coding gene Chr14:6417478-6431789 (-)
BALB/cJ MGP_BALBcJ_G0020955
 protein coding gene Chr14:6327620-6340242 (-)
C3H/HeJ MGP_C3HHeJ_G0020739
 protein coding gene Chr14:6519049-6531302 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021388
 protein coding gene Chr14:6651000-6663485 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018957
 protein coding gene Chr14:6968170-6980469 (-)
CAST/EiJ MGP_CASTEiJ_G0020261
 protein coding gene Chr14:6498626-6514160 (-)
CBA/J MGP_CBAJ_G0020705
 protein coding gene Chr14:6892309-6904467 (-)
DBA/2J MGP_DBA2J_G0020828
 protein coding gene Chr14:6238186-6251930 (-)
FVB/NJ MGP_FVBNJ_G0020810
 protein coding gene Chr14:6171010-6178376 (-)
LP/J MGP_LPJ_G0020904
 protein coding gene Chr14:6485321-6499781 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020836
 protein coding gene Chr14:6944448-6956444 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021421
 protein coding gene Chr14:6375340-6387582 (-)
PWK/PhJ MGP_PWKPhJ_G0020013
 protein coding gene Chr14:6236065-6249281 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019833
 protein coding gene Chr14:6475354-6487404 (-)
WSB/EiJ MGP_WSBEiJ_G0020319
 protein coding gene Chr14:6409788-6423164 (-)



Homology
more
  • Human Ortholog
    THOC7, THO complex subunit 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    THOC7, THO complex subunit 7
  • Synonyms
    fSAP24, hTREX30, NIF3L1BP1
  • Links
    NCBI Gene ID: 80145
    neXtProt AC: NX_Q6I9Y2
    UniProt: Q6I9Y2

  • Chr Location
    3p14.1; chr3:63833870-63864484 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    1 images
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality between implantation and somite formation. In vitro outgrowth assays show that blastocysts hatch from the zona pellucida but form irregular outgrowths.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    5
  • cDNA Data
    21
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66231 NCBI Gene Model | MGI Sequence Detail 12841 C57BL/6J ±  kb
    transcript NM_001426030 RefSeq | MGI Sequence Detail 1277 C57BL/6  
    polypeptide Q7TMY4 UniProt | EBI | MGI Sequence Detail 204 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 21

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2444366
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory