Dmap1 MGI Mouse Gene Detail - MGI:1913483 - DNA methyltransferase 1-associated protein 1

Symbol

Dmap1
Name

DNA methyltransferase 1-associated protein 1
Synonyms

1500016M21Rik, mKIAA1425

Feature Type

protein coding gene
IDs

MGI:1913483
NCBI Gene: 66233
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr4:117531878-117539450 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 53.46 cM, cytoband D1
Mapping Data

2 experiments

SNPs within 2kb

191 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913483	protein coding gene	Chr4:117531878-117539470 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028652	protein coding gene	Chr4:118673507-118681099 (-)
A/J	MGP_AJ_G0028613	protein coding gene	Chr4:114098942-114106534 (-)
AKR/J	MGP_AKRJ_G0028563	protein coding gene	Chr4:116594973-116602565 (-)
BALB/cJ	MGP_BALBcJ_G0028634	protein coding gene	Chr4:114721076-114728667 (-)
C3H/HeJ	MGP_C3HHeJ_G0028348	protein coding gene	Chr4:118174971-118182567 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029075	protein coding gene	Chr4:123235134-123242726 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026359	protein coding gene	Chr4:108124475-108132455 (-)
CAST/EiJ	MGP_CASTEiJ_G0027782	protein coding gene	Chr4:115383708-115391281 (-)
CBA/J	MGP_CBAJ_G0028315	protein coding gene	Chr4:126615795-126623426 (-)
DBA/2J	MGP_DBA2J_G0028463	protein coding gene	Chr4:114717464-114725056 (-)
FVB/NJ	MGP_FVBNJ_G0028431	protein coding gene	Chr4:113233823-113241416 (-)
LP/J	MGP_LPJ_G0028565	protein coding gene	Chr4:118844357-118851949 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028458	protein coding gene	Chr4:131528688-131536281 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029112	protein coding gene	Chr4:117739076-117746668 (-)
PWK/PhJ	MGP_PWKPhJ_G0027508	protein coding gene	Chr4:111533227-111540867 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027331	protein coding gene	Chr4:114049138-114056725 (-)
WSB/EiJ	MGP_WSBEiJ_G0027861	protein coding gene	Chr4:117629524-117637117 (-)

Human Ortholog

DMAP1, DNA methyltransferase 1 associated protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DMAP1, DNA methyltransferase 1 associated protein 1
Synonyms

DNMAP1, DNMTAP1, EAF2, MEAF2, SWC4
Links

HGNC:18291

NCBI Gene ID: 55929

neXtProt AC: NX_Q9NPF5

UniProt: Q9NPF5
Chr Location

1p34.1; chr1:44213455-44220681 (+) GRCh38

MGI Vertebrate Homology

Dmap1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DMAP1
Gene Tree

Dmap1

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Gene trapped

1
Radiation induced

1
Targeted

6
Genomic Mutations

4 involving Dmap1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available

Mice homozygous for a knock-out allele die prior to implantation with no 8-cell embryos detected.

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All GO Annotations

41
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

758
Tissues

45
cDNA Data

71
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dmap1

ZFIN dmap1

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All Sequences

47
RefSeq

8
UniProt

1
CCDS

CCDS18536.1

Ensembl

ENSMUSG00000009640 (Evidence)
NCBI Gene

66233

			Length	Strain/Species	Flank
genomic	66233	NCBI Gene Model \| MGI Sequence Detail	7573	C57BL/6J	± kb
transcript	NM_001419061	RefSeq \| MGI Sequence Detail	1678	C57BL/6
polypeptide	Q9JI44	UniProt \| EBI \| MGI Sequence Detail	468	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006533 DNA methyltransferase 1-associated protein 1

(term hierarchy)
InterPro Domains

IPR032563 DAMP1, SANT/Myb-like domain

IPR008468 DNA methyltransferase 1-associated 1

IPR027109 SWR1-complex protein 4/DNA methyltransferase 1-associated protein 1

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All nucleic 71

cDNA 71

Microarray probesets 3

Summaries

All 51

Developmental Gene Expression 2

Gene Ontology 10

Phenotypes 14
Earliest

J:81304 Rountree MR, et al., DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nat Genet. 2000 Jul;25(3):269-77
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dmap1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr42991	Chr4:117539430-117539476 (-)	-3 bp
Tssr42990	Chr4:117539413-117539422 (-)	32 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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