Taf13 MGI Mouse Gene Detail - MGI:1913500 - TATA-box binding protein associated factor 13

Symbol

Taf13
Name

TATA-box binding protein associated factor 13
Synonyms

1810004N01Rik, 2010309N11Rik

Feature Type

protein coding gene
IDs

MGI:1913500
NCBI Gene: 99730
Alliance

gene page

Sequence Map

Chr3:108479015-108489384 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 47.34 cM
Mapping Data

2 experiments

SNPs within 2kb

339 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913500	protein coding gene	Chr3:108479014-108490538 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027781	protein coding gene	Chr3:110132482-110148463 (+)
A/J	MGP_AJ_G0027741	protein coding gene	Chr3:106637663-106649411 (+)
AKR/J	MGP_AKRJ_G0027706	protein coding gene	Chr3:109230217-109241215 (+)
BALB/cJ	MGP_BALBcJ_G0027753	protein coding gene	Chr3:106337924-106349551 (+)
C3H/HeJ	MGP_C3HHeJ_G0027483	protein coding gene	Chr3:109590386-109601912 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028197	protein coding gene	Chr3:114235607-114248283 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025535	protein coding gene	Chr3:102775114-102787080 (+)
CAST/EiJ	MGP_CASTEiJ_G0026939	protein coding gene	Chr3:108983918-108993321 (+)
CBA/J	MGP_CBAJ_G0027458	protein coding gene	Chr3:118131075-118148920 (+)
DBA/2J	MGP_DBA2J_G0027600	protein coding gene	Chr3:105815715-105827241 (+)
FVB/NJ	MGP_FVBNJ_G0027568	protein coding gene	Chr3:103703937-103716748 (+)
LP/J	MGP_LPJ_G0027707	protein coding gene	Chr3:111549641-111563092 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027598	protein coding gene	Chr3:124183912-124198559 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028252	protein coding gene	Chr3:108834267-108849852 (+)
PWK/PhJ	MGP_PWKPhJ_G0026665	protein coding gene	Chr3:105568841-105580711 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026485	protein coding gene	Chr3:106975831-106977418 (+)
WSB/EiJ	MGP_WSBEiJ_G0027019	protein coding gene	Chr3:109369463-109381212 (+)

Human Ortholog

TAF13, TATA-box binding protein associated factor 13

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TAF13, TATA-box binding protein associated factor 13
Synonyms

MRT60, TAF2K, TAF(II)18, TAFII-18, TAFII18
Links

HGNC:11546

NCBI Gene ID: 6884

neXtProt AC: NX_Q15543

UniProt: Q15543
Chr Location

1p13.3; chr1:109062496-109076012 (-) GRCh38

MGI Vertebrate Homology

Taf13 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TAF13
Gene Tree

Taf13

Diseases

1 with human TAF13 associations

				Human Disease	Mouse Models
				autosomal recessive intellectual developmental disorder 60 IDs autosomal recessive intellectual developmental disorder 60 DOID:0081222 OMIM:617432

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

21 phenotypes from 1 allele in 1 genetic background
1 images
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

11
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Taf13
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele reach the egg-cylinder stage but fail to initiate gastrulation and show embryonic growth retardation, a size reduction of the epiblast, extraembryonic ectoderm and pro-amniotic cavity, absence of the primitive node, head folds, allantois, amnion and chorion, and complete embryonic lethality prior to organogenesis.

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All GO Annotations

27
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

791
Tissues

27
cDNA Data

52
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase taf13

ZFIN taf13

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All Sequences

35
RefSeq

2
UniProt

1
CCDS

CCDS17764.1

Ensembl

ENSMUSG00000048100 (Evidence)
NCBI Gene

99730

			Length	Strain/Species	Flank
genomic	99730	NCBI Gene Model \| MGI Sequence Detail	10370	C57BL/6J	± kb
transcript	NM_025444	RefSeq \| MGI Sequence Detail	1289	C57BL/6
polypeptide	P61216	UniProt \| EBI \| MGI Sequence Detail	124	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000016018 transcription initiation factor TFIID subunit 13

(term hierarchy)
InterPro Domains

IPR009072 Histone-fold

IPR003195 Transcription initiation factor IID, subunit 13

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All nucleic 56

cDNA 54

Primer pair 2

Microarray probesets 6

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MGI:1919442, MGI:2139811

Summaries

All 48

Developmental Gene Expression 10

Diseases 1

Gene Ontology 8

Phenotypes 15
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:348275 He XD, et al., TATA-binding associated factors have distinct roles during early mammalian development. Dev Biol. 2024 Jul;511:53-62

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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