Tmem126a MGI Mouse Gene Detail - MGI:1913521

Symbol

Tmem126a
Name

transmembrane protein 126A
Synonyms

1810020E01Rik

Feature Type

protein coding gene
IDs

MGI:1913521
NCBI Gene: 66271
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr7:90099908-90106411 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 50.59 cM, cytoband E1
Mapping Data

2 experiments

SNPs within 2kb

226 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913521	protein coding gene	Chr7:90099908-90106437 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032508	protein coding gene	Chr7:92877299-92883792 (-)
A/J	MGP_AJ_G0032482	protein coding gene	Chr7:90636713-90643215 (-)
AKR/J	MGP_AKRJ_G0032418	protein coding gene	Chr7:92761081-92768452 (-)
BALB/cJ	MGP_BALBcJ_G0032493	protein coding gene	Chr7:90283153-90289988 (-)
C3H/HeJ	MGP_C3HHeJ_G0032208	protein coding gene	Chr7:93144637-93152014 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0032991	protein coding gene	Chr7:96502890-96510058 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029986	protein coding gene	Chr7:93519403-93526109 (-)
CAST/EiJ	MGP_CASTEiJ_G0031535	protein coding gene	Chr7:84582784-84590001 (-)
CBA/J	MGP_CBAJ_G0032175	protein coding gene	Chr7:99715194-99722186 (-)
DBA/2J	MGP_DBA2J_G0032327	protein coding gene	Chr7:89071096-89077576 (-)
FVB/NJ	MGP_FVBNJ_G0032283	protein coding gene	Chr7:88939538-88945993 (-)
LP/J	MGP_LPJ_G0032416	protein coding gene	Chr7:94149128-94155870 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032317	protein coding gene	Chr7:100721359-100729279 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033013	protein coding gene	Chr7:92039620-92046129 (-)
PWK/PhJ	MGP_PWKPhJ_G0031253	protein coding gene	Chr7:82111787-82118319 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031096	protein coding gene	Chr7:79360720-79366850 (-)
WSB/EiJ	MGP_WSBEiJ_G0031652	protein coding gene	Chr7:92713311-92719788 (-)

Human Ortholog

TMEM126A, transmembrane protein 126A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM126A, transmembrane protein 126A
Synonyms

OPA7
Links

HGNC:25382

NCBI Gene ID: 84233

neXtProt AC: NX_Q9H061

UniProt: Q9H061
Chr Location

11q14.1; chr11:85647967-85656547 (+) GRCh38

MGI Vertebrate Homology

Tmem126a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMEM126A
Gene Tree

Tmem126a

Diseases

1 with human TMEM126A associations

				Human Disease	Mouse Models
				optic atrophy 7 IDs optic atrophy 7 DOID:0111437 MESH:C567833 OMIM:612989

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
37 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

7
Radiation induced

3
Targeted

5
Genomic Mutations

4 involving Tmem126a
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

17 strains or lines available

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All GO Annotations

17
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

65
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem126a

ZFIN tmem126a

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All Sequences

41
RefSeq

3
UniProt

3
CCDS

CCDS21447.1

Ensembl

ENSMUSG00000030615 (Evidence)
NCBI Gene

66271

			Length	Strain/Species	Flank
genomic	66271	NCBI Gene Model \| MGI Sequence Detail	6504	C57BL/6J	± kb
transcript	NM_025460	RefSeq \| MGI Sequence Detail	773	C57BL/6
polypeptide	Q9D8Y1	UniProt \| EBI \| MGI Sequence Detail	196	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000032736 transmembrane protein 126A

(term hierarchy)
InterPro Domains

IPR009801 Transmembrane protein 126
GlyGen

Q9D8Y1 1 site, 1 O-linked glycan (1 site)

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All nucleic 65

cDNA 65

Microarray probesets 3

Summaries

All 64

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 37
Earliest

J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tmem126a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr73539	Chr7:90106375-90106421 (-)	13 bp
Tssr73538	Chr7:90106350-90106361 (-)	55 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24