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Cox16 Gene Detail
Summary
  • Symbol
    Cox16
  • Name
    cytochrome c oxidase assembly protein 16
  • Synonyms
    1810020G14Rik, 1810055I05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913522
    NCBI Gene: 66272
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:81405800-81531901 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 37.60 cM, cytoband D2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1698 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913522
 protein coding gene Chr12:81405626-81531911 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019900
 protein coding gene Chr12:81811561-81944837 (-)
A/J MGP_AJ_G0019858
 protein coding gene Chr12:78811268-78954351 (-)
AKR/J MGP_AKRJ_G0019833
 protein coding gene Chr12:80977700-81109772 (-)
BALB/cJ MGP_BALBcJ_G0019837
 protein coding gene Chr12:79052086-79182414 (-)
C3H/HeJ MGP_C3HHeJ_G0019643
 protein coding gene Chr12:81433849-81566436 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020289
 protein coding gene Chr12:84188196-84344504 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017908
 protein coding gene Chr12:75900687-75915359 (-)
CAST/EiJ MGP_CASTEiJ_G0019193
 protein coding gene Chr12:76301286-76443813 (-)
CBA/J MGP_CBAJ_G0019614
 protein coding gene Chr12:87453870-87610192 (-)
DBA/2J MGP_DBA2J_G0019729
 protein coding gene Chr12:78403713-78535391 (-)
FVB/NJ MGP_FVBNJ_G0019715
 protein coding gene Chr12:77240941-77393985 (-)
LP/J MGP_LPJ_G0019801
 protein coding gene Chr12:81708865-81858438 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019754
 protein coding gene Chr12:90451288-90612274 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020324
 protein coding gene Chr12:80493180-80638702 (-)
PWK/PhJ MGP_PWKPhJ_G0018959
 protein coding gene Chr12:72821267-72947442 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018753
 protein coding gene Chr12:75016886-75140309 (-)
WSB/EiJ MGP_WSBEiJ_G0019246
 protein coding gene Chr12:81136388-81281559 (-)



Homology
more
  • Human Ortholog
    COX16, cytochrome c oxidase assembly factor COX16
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COX16, cytochrome c oxidase assembly factor COX16
  • Synonyms
    C14orf112, hCOX16, HSPC203, MC4DN22
  • Links
    NCBI Gene ID: 51241
    neXtProt AC: NX_Q9P0S2
    UniProt: Q9P0S2

  • Chr Location
    14q24.2; chr14:70325081-70416984 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human COX16 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    1
  • Targeted
    1
  • Genomic Mutations
    1 involving Cox16
  • Find Mice (IMSR)
    20 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    7
  • cDNA Data
    18
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000091803 Ensembl Gene Model | MGI Sequence Detail 126102 C57BL/6J ±  kb
transcript ENSMUST00000002757 Ensembl | MGI Sequence Detail 2007 Not Applicable  
polypeptide ENSMUSP00000002757 Ensembl | MGI Sequence Detail 106 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000005772 cytochrome c oxidase assembly protein COX16, mitochondrial
    (term hierarchy)
  • InterPro Domains
    IPR020164 Cytochrome c oxidase assembly protein COX16
Molecular
Reagents
less
  • All nucleic 21
    cDNA 20
    Other 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:1922914, MGI:3034740
References
more
  • Summaries
    All 35
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory