Smim20 MGI Mouse Gene Detail - MGI:1913528 - small integral membrane protein 20

Symbol

Smim20
Name

small integral membrane protein 20
Synonyms

1110067B18Rik, 1810013D10Rik

Feature Type

protein coding gene
IDs

MGI:1913528
NCBI Gene: 66278
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr5:53424448-53435882 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 29.05 cM
Mapping Data

2 experiments

SNPs within 2kb

392 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913528	protein coding gene	Chr5:53424425-53435882 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029553	protein coding gene	Chr5:52298786-52310238 (+)
A/J	MGP_AJ_G0029521	protein coding gene	Chr5:50460380-50471997 (+)
AKR/J	MGP_AKRJ_G0029469	protein coding gene	Chr5:52197796-52209304 (+)
BALB/cJ	MGP_BALBcJ_G0029530	protein coding gene	Chr5:50949064-50960236 (+)
C3H/HeJ	MGP_C3HHeJ_G0029253	protein coding gene	Chr5:52336500-52351942 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029984	protein coding gene	Chr5:54459871-54471201 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027224	protein coding gene	Chr5:47215642-47226826 (+)
CAST/EiJ	MGP_CASTEiJ_G0028661	protein coding gene	Chr5:51345010-51358075 (+)
CBA/J	MGP_CBAJ_G0029222	protein coding gene	Chr5:56137586-56149047 (+)
DBA/2J	MGP_DBA2J_G0029368	protein coding gene	Chr5:50524491-50536708 (+)
FVB/NJ	MGP_FVBNJ_G0029328	protein coding gene	Chr5:49861415-49874113 (+)
LP/J	MGP_LPJ_G0029453	protein coding gene	Chr5:52763909-52775366 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029356	protein coding gene	Chr5:57208126-57219581 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030017	protein coding gene	Chr5:51673409-51685673 (+)
PWK/PhJ	MGP_PWKPhJ_G0028385	protein coding gene	Chr5:49585740-49598207 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028219	protein coding gene	Chr5:51115071-51128665 (+)
WSB/EiJ	MGP_WSBEiJ_G0028742	protein coding gene	Chr5:51730881-51744158 (+)

Human Ortholog

SMIM20, small integral membrane protein 20

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SMIM20, small integral membrane protein 20
Synonyms

C4orf52, MITRAC7, PNX
Links

HGNC:37260

NCBI Gene ID: 389203

neXtProt AC: NX_Q8N5G0

UniProt: Q8N5G0
Chr Location

4p15.2; chr4:25861830-25929813 (+) GRCh38

MGI Vertebrate Homology

Smim20 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SMIM20
Gene Tree

Smim20

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

2
Endonuclease-mediated

2
Radiation induced

1
Spontaneous

1
Targeted

1
Genomic Mutations

4 involving Smim20
Find Mice (IMSR)

6 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for knock-out allele exhibit normal fertility and have no major alterations in their metabolic response to a high-fat diet but show altered behavior in an open field test.

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All GO Annotations

7
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN smim20

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All Sequences

47
RefSeq

2
UniProt

3
CCDS

CCDS51502.1

Ensembl

ENSMUSG00000061461 (Evidence)
NCBI Gene

66278

			Length	Strain/Species	Flank
genomic	66278	NCBI Gene Model \| MGI Sequence Detail	11435	C57BL/6J	± kb
transcript	NM_001145433	RefSeq \| MGI Sequence Detail	1036	C57BL/6
polypeptide	D3Z7Q2	UniProt \| EBI \| MGI Sequence Detail	69	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000059933 small integral membrane protein 20

(term hierarchy)
InterPro Domains

IPR027917 Small integral membrane protein 20

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All nucleic 10

Genomic 2

cDNA 8

Microarray probesets 3

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MGI:1919046, MGI:2141348

Summaries

All 45

Gene Ontology 4

Phenotypes 23
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:350521 McIlwraith EK, et al., Phoenixin knockout mice show no impairment in fertility or differences in metabolic response to a high-fat diet, but exhibit behavioral differences in an open field test. J Neuroendocrinol. 2024 May 10;:e13398

TSS for Smim20:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr46209	Chr5:53424445-53424469 (+)	9 bp
Tssr46210	Chr5:53424472-53424531 (+)	54 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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