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Sec11c Gene Detail
Summary
  • Symbol
    Sec11c
  • Name
    SEC11 homolog C, signal peptidase complex subunit
  • Synonyms
    1810029G24Rik, Sec11l3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913536
    NCBI Gene: 66286
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:65933649-65950731 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 38.98 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    640 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913536
 protein coding gene Chr18:65933586-65950755 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024511
 protein coding gene Chr18:65961067-65978388 (+)
A/J MGP_AJ_G0024478
 protein coding gene Chr18:63091711-63108881 (+)
AKR/J MGP_AKRJ_G0024448
 protein coding gene Chr18:64876090-64893214 (+)
BALB/cJ MGP_BALBcJ_G0024477
 protein coding gene Chr18:63233693-63251022 (+)
C3H/HeJ MGP_C3HHeJ_G0024245
 protein coding gene Chr18:65084182-65101308 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024924
 protein coding gene Chr18:67715518-67732823 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022355
 protein coding gene Chr18:62541506-62558756 (+)
CAST/EiJ MGP_CASTEiJ_G0023718
 protein coding gene Chr18:65079321-65098142 (+)
CBA/J MGP_CBAJ_G0024215
 protein coding gene Chr18:69956790-69974114 (+)
DBA/2J MGP_DBA2J_G0024345
 protein coding gene Chr18:62761357-62778381 (+)
FVB/NJ MGP_FVBNJ_G0024311
 protein coding gene Chr18:62142923-62159940 (+)
LP/J MGP_LPJ_G0024429
 protein coding gene Chr18:65815185-65832304 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024340
 protein coding gene Chr18:71352724-71369866 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024971
 protein coding gene Chr18:65082398-65099417 (+)
PWK/PhJ MGP_PWKPhJ_G0023461
 protein coding gene Chr18:63009972-63027209 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023266
 protein coding gene Chr18:65240187-65260567 (+)
WSB/EiJ MGP_WSBEiJ_G0023782
 protein coding gene Chr18:64948387-64965461 (+)



Homology
more
  • Human Ortholog
    SEC11C, SEC11 homolog C, signal peptidase complex subunit
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEC11C, SEC11 homolog C, signal peptidase complex subunit
  • Synonyms
    SEC11L3, SPC21, SPCS4C
  • Links
    NCBI Gene ID: 90701
    neXtProt AC: NX_Q9BY50
    UniProt: Q9BY50

  • Chr Location
    18q21.32; chr18:59139866-59158832 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    831
  • Tissues
    100
  • cDNA Data
    73
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 66286 NCBI Gene Model | MGI Sequence Detail 17083 C57BL/6J ±  kb
transcript NM_025468 RefSeq | MGI Sequence Detail 770 C57BL/6  
polypeptide Q9D8V7 UniProt | EBI | MGI Sequence Detail 192 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 73
    cDNA 73

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory