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Smurf2 Gene Detail
Summary
  • Symbol
    Smurf2
  • Name
    SMAD specific E3 ubiquitin protein ligase 2
  • Synonyms
    2810411E22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913563
    NCBI Gene: 66313
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:106710892-106811541 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 70.03 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1970 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913563
 protein coding gene Chr11:106710887-106811544 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019315
 protein coding gene Chr11:110157724-110269796 (-)
A/J MGP_AJ_G0019283
 protein coding gene Chr11:105452922-105555300 (-)
AKR/J MGP_AKRJ_G0019252
 protein coding gene Chr11:108595412-108701613 (-)
BALB/cJ MGP_BALBcJ_G0019257
 protein coding gene Chr11:105868750-105969132 (-)
C3H/HeJ MGP_C3HHeJ_G0019066
 protein coding gene Chr11:108890493-108994008 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019707
 protein coding gene Chr11:113559098-113671381 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017331
 protein coding gene Chr11:102722255-102826760 (-)
CAST/EiJ MGP_CASTEiJ_G0018619
 protein coding gene Chr11:109979365-110086234 (-)
CBA/J MGP_CBAJ_G0019035
 protein coding gene Chr11:118259125-118365818 (-)
DBA/2J MGP_DBA2J_G0019147
 protein coding gene Chr11:104922649-105023806 (-)
FVB/NJ MGP_FVBNJ_G0019138
 protein coding gene Chr11:104436763-104537669 (-)
LP/J MGP_LPJ_G0019217
 protein coding gene Chr11:110607807-110710685 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019168
 protein coding gene Chr11:117501719-117609984 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019744
 protein coding gene Chr11:109116468-109221145 (-)
PWK/PhJ MGP_PWKPhJ_G0018384
 protein coding gene Chr11:106038139-106146955 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018175
 protein coding gene Chr11:108888169-108996594 (-)
WSB/EiJ MGP_WSBEiJ_G0018670
 protein coding gene Chr11:109091144-109193860 (-)



Homology
more
  • Human Ortholog
    SMURF2, SMAD specific E3 ubiquitin protein ligase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMURF2, SMAD specific E3 ubiquitin protein ligase 2
  • Links
    NCBI Gene ID: 64750
    neXtProt AC: NX_Q9HAU4
    UniProt: Q9HAU4

  • Chr Location
    17q23.3-q24.1; chr17:64542282-64662307 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Smurf2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 4 alleles in 4 genetic backgrounds
    16 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele occasionally exhibit kinked or looped tails and abnormal vertebrae. Mice homozygous or heterozygous for a gene trap allele exhibit increased tumor incidence and delayed cellular senescence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    755
  • Tissues
    37
  • cDNA Data
    141
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018363 Ensembl Gene Model | MGI Sequence Detail 100650 C57BL/6J ±  kb
    transcript ENSMUST00000092517 Ensembl | MGI Sequence Detail 3125 Not Applicable  
    polypeptide ENSMUSP00000090177 Ensembl | MGI Sequence Detail 748 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 142
      cDNA 141
      Primer pair 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:2144225, MGI:2144252
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 7
      Phenotypes 23
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory