Tpd52l2 Gene Detail

Summary

• Symbol
  Tpd52l2
• Name
  tumor protein D52-like 2
• Synonyms
  2810411G23Rik, D54

• Feature Type
  protein coding gene
• IDs
  MGI:1913564
  NCBI Gene: 66314
• Alliance
  gene page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr2:181138935-181159759 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 2, 103.63 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  335 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913564	protein coding gene	Chr2:181138935-181160103 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027026	protein coding gene	Chr2:188094724-188118661 (+)
A/J	MGP_AJ_G0026992	protein coding gene	Chr2:180348141-180369052 (+)
AKR/J	MGP_AKRJ_G0026962	protein coding gene	Chr2:185758374-185779339 (+)
BALB/cJ	MGP_BALBcJ_G0027000	protein coding gene	Chr2:180827761-180848552 (+)
C3H/HeJ	MGP_C3HHeJ_G0026742	protein coding gene	Chr2:186108515-186129324 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027446	protein coding gene	Chr2:193543092-193569296 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024810	protein coding gene	Chr2:171035367-171056096 (+)
CAST/EiJ	MGP_CASTEiJ_G0026201	protein coding gene	Chr2:184372000-184394852 (+)
CBA/J	MGP_CBAJ_G0026719	protein coding gene	Chr2:200542376-200563176 (+)
DBA/2J	MGP_DBA2J_G0026856	protein coding gene	Chr2:179448086-179468856 (+)
FVB/NJ	MGP_FVBNJ_G0026822	protein coding gene	Chr2:178064477-178086270 (+)
LP/J	MGP_LPJ_G0026958	protein coding gene	Chr2:188119844-188140740 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026842	protein coding gene	Chr2:203106390-203128045 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027506	protein coding gene	Chr2:185725589-185746601 (+)
PWK/PhJ	MGP_PWKPhJ_G0025937	protein coding gene	Chr2:176973153-176994054 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025737	protein coding gene	Chr2:182226370-182247187 (+)
WSB/EiJ	MGP_WSBEiJ_G0026273	protein coding gene	Chr2:186712401-186733340 (+)

Homology

• Human Ortholog
  TPD52L2, TPD52 like 2

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  TPD52L2, TPD52 like 2
  
• Synonyms
  D54, TPD54
• Links
  HGNC:12007

  NCBI Gene ID: 7165

  neXtProt AC: NX_O43399

  UniProt: O43399

  
  
• Chr Location
  20q13.33; chr20:63865228-63891545 (+)  GRCh38

---

• MGI Vertebrate Homology
  Tpd52l2 stringent orthology
  1 human;1 mouse;1 rat;2 zebrafish
  
• HCOP
  vertebrate homology predictions: TPD52L2
• Gene Tree
  Tpd52l2
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotypes from 1 allele in 1 genetic background
  7 phenotype references
  

• All Mutations and Alleles
  7
• Gene trapped
  5
• Targeted
  2
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  17 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Female mice homozygous for a knock-out allele exhibit decreased body length and absent or minimal hepatic lipidosis.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  6
• GO References
  3

Expression

• Assay Results
  706
• cDNA Data
  19

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  GEISHA TPD52L2
  Xenbase tpd52l2
  ZFIN tpd52l2a, tpd52l2b

Sequences &
Gene Models

• All Sequences
  125
• RefSeq
  52
• UniProt
  9
• CCDS
  CCDS17214.1, CCDS71219.1, CCDS71220.1, CCDS71221.1, CCDS89610.1

• Ensembl
  ENSMUSG00000000827 (Evidence)
• NCBI Gene
  66314

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000000827	Ensembl Gene Model | MGI Sequence Detail	20825	C57BL/6J
transcript	ENSMUST00000108799	Ensembl | MGI Sequence Detail	985	Not Applicable
polypeptide	ENSMUSP00000104427	Ensembl | MGI Sequence Detail	229	Not Applicable

Protein
Information

• UniProt
  9 Sequences
• Protein Ontology
  PR:000016573 tumor protein D54
  (term hierarchy)
• InterPro Domains
  IPR012341 Six-hairpin glycosidase-like superfamily
  IPR007327 Tumour protein D52
• GlyGen
  Q9CYZ2 5 sites, 1 O-linked glycan (5 sites)

Molecular
Reagents

• All nucleic 19

  cDNA 19

  
  

  Microarray probesets 6

Other
Accession IDs

MGI:2139162, MGI:2139523

References

• Summaries
  All 31

  Gene Ontology 3

  Phenotypes 7
• Earliest
  J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
• Latest
  J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tpd52l2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr22313	Chr2:181138962-181139009 (+)	51 bp
Tssr22314	Chr2:181139016-181139037 (+)	92 bp
Tssr22315	Chr2:181148495-181148499 (+)	9,562 bp