Aqp11 MGI Mouse Gene Detail - MGI:1913583

Symbol

Aqp11
Name

aquaporin 11
Synonyms

1700015P13Rik, sjds

Feature Type

protein coding gene
IDs

MGI:1913583
NCBI Gene: 66333
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr7:97375586-97387454 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 53.57 cM
Mapping Data

2 experiments

SNPs within 2kb

450 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913583	protein coding gene	Chr7:97373213-97387496 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032530	protein coding gene	Chr7:100432104-100446417 (-)
A/J	MGP_AJ_G0032504	protein coding gene	Chr7:97943067-97957384 (-)
AKR/J	MGP_AKRJ_G0032440	protein coding gene	Chr7:100279856-100294162 (-)
BALB/cJ	MGP_BALBcJ_G0032515	protein coding gene	Chr7:97632769-97647078 (-)
C3H/HeJ	MGP_C3HHeJ_G0032230	protein coding gene	Chr7:100630435-100644824 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033013	protein coding gene	Chr7:104344080-104358363 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030008	protein coding gene	Chr7:100390383-100405178 (-)
CAST/EiJ	MGP_CASTEiJ_G0031557	protein coding gene	Chr7:92152680-92167013 (-)
CBA/J	MGP_CBAJ_G0032197	protein coding gene	Chr7:107865234-107879606 (-)
DBA/2J	MGP_DBA2J_G0032349	protein coding gene	Chr7:96299738-96314123 (-)
FVB/NJ	MGP_FVBNJ_G0032305	protein coding gene	Chr7:96090985-96105263 (-)
LP/J	MGP_LPJ_G0032438	protein coding gene	Chr7:101752348-101766662 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032338	protein coding gene	Chr7:109401230-109420473 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033035	protein coding gene	Chr7:99560217-99574521 (-)
PWK/PhJ	MGP_PWKPhJ_G0031275	protein coding gene	Chr7:89360957-89376186 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031118	protein coding gene	Chr7:86804100-86818410 (-)
WSB/EiJ	MGP_WSBEiJ_G0031674	protein coding gene	Chr7:100202158-100216804 (-)

Human Ortholog

AQP11, aquaporin 11

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AQP11, aquaporin 11
Synonyms

AQPX1
Links

HGNC:19940

NCBI Gene ID: 282679

neXtProt AC: NX_Q8NBQ7

UniProt: Q8NBQ7
Chr Location

11q14.1; chr11:77589391-77610356 (+) GRCh38

MGI Vertebrate Homology

Aqp11 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AQP11
Protein SuperFamily

Aquaporin_11/12
Gene Tree

Aqp11

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Phenotype Summary

29 phenotypes from 4 alleles in 7 genetic backgrounds
38 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

3
Radiation induced

2
Targeted

4
Genomic Mutations

3 involving Aqp11
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display premature death, kidney failure, polycystic kidneys with cysts originating from the proximal tubules, and growth retardation. Mice homozygous for an ENU-induced mutation are apparently healthy but exhibit sudden death between2 and 3 weeks of age.

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All GO Annotations

44
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

867
Tissues

125
cDNA Data

16
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA AQP11

Xenbase aqp11

ZFIN aqp11

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All Sequences

47
RefSeq

2
UniProt

3
CCDS

CCDS21463.1

Ensembl

ENSMUSG00000042797 (Evidence)
NCBI Gene

66333

			Length	Strain/Species	Flank
genomic	66333	NCBI Gene Model \| MGI Sequence Detail	11869	C57BL/6J	± kb
transcript	NM_175105	RefSeq \| MGI Sequence Detail	1322	C57BL/6
polypeptide	Q8BHH1	UniProt \| EBI \| MGI Sequence Detail	271	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000004179 aquaporin-11

(term hierarchy)
InterPro Domains

IPR023266 Aquaporin 11

IPR016697 Aquaporin 11/12

IPR051883 Aquaporin-11/12 water channel

IPR023271 Aquaporin-like

IPR000425 Major intrinsic protein

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All nucleic 22

cDNA 17

Primer pair 3

Other 2

Microarray probesets 6

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MGI:1338787, MGI:2142021

Summaries

All 77

Developmental Gene Expression 9

Gene Ontology 15

Phenotypes 38
Earliest

J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Aqp11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr73591	Chr7:97387429-97387524 (-)	-23 bp
Tssr73590	Chr7:97387201-97387263 (-)	222 bp
Tssr73589	Chr7:97387184-97387191 (-)	266 bp
Tssr73588	Chr7:97386818-97386838 (-)	626 bp
Tssr73587	Chr7:97379848-97379867 (-)	7,596 bp
Tssr73586	Chr7:97378577-97378601 (-)	8,865 bp
Tssr73585	Chr7:97378276-97378287 (-)	9,172 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24