Lce3b Gene Detail

Summary

• Symbol
  Lce3b
• Name
  late cornified envelope 3B
• Synonyms
  2310007F04Rik, Sprrl6A

• Feature Type
  protein coding gene
• IDs
  MGI:1913594
  NCBI Gene: 66344
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr3:92840286-92841404 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 3, 40.14 cM, cytoband F2
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  192 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913594	protein coding gene	Chr3:92840286-92841404 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027523	protein coding gene	Chr3:93408259-93409377 (+)
A/J	MGP_AJ_G0027490	protein coding gene	Chr3:90461456-90462686 (+)
AKR/J	MGP_AKRJ_G0027455	protein coding gene	Chr3:92583094-92587262 (+)
BALB/cJ	MGP_BALBcJ_G0027498	protein coding gene	Chr3:90272039-90273157 (+)
C3H/HeJ	MGP_C3HHeJ_G0027236	protein coding gene	Chr3:92801977-92803095 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027940	protein coding gene	Chr3:96951699-96952817 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025289	protein coding gene	Chr3:87082098-87083380 (+)
CAST/EiJ	MGP_CASTEiJ_G0026684	protein coding gene	Chr3:92228610-92239994 (+)
CBA/J	MGP_CBAJ_G0027212	protein coding gene	Chr3:100275891-100277009 (+)
DBA/2J	MGP_DBA2J_G0027349	protein coding gene	Chr3:89792271-89793489 (+)
FVB/NJ	MGP_FVBNJ_G0027317	protein coding gene	Chr3:87947865-87948983 (+)
LP/J	MGP_LPJ_G0027457	protein coding gene	Chr3:94618187-94619305 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027343	protein coding gene	Chr3:106572686-106573804 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028000	protein coding gene	Chr3:92325261-92326477 (+)
PWK/PhJ	MGP_PWKPhJ_G0026413	protein coding gene	Chr3:89673284-89674441 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026234	protein coding gene	Chr3:90658414-90659530 (+)
WSB/EiJ	MGP_WSBEiJ_G0026766	protein coding gene	Chr3:92687303-92688421 (+)

Homology

• Human Ortholog
  LCE3B, late cornified envelope 3B

• Vertebrate Orthologs
  5

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  LCE3B, late cornified envelope 3B
  
• Synonyms
  LEP14
• Links
  HGNC:29462

  NCBI Gene ID: 353143

  neXtProt AC: NX_Q5TA77

  UniProt: Q5TA77

  
  
• Chr Location
  1q21.3; chr1:152613811-152614098 (+)  GRCh38

---

• Human Ortholog
  LCE3C, late cornified envelope 3C
  
• Synonyms
  LEP15, SPRL3A
• Links
  HGNC:16612

  NCBI Gene ID: 353144

  neXtProt AC: NX_Q5T5A8

  UniProt: Q5T5A8

  
  
• Chr Location
  1q21.3; chr1:152600234-152601086 (+)  GRCh38

---

• Human Ortholog
  LCE3D, late cornified envelope 3D
  
• Synonyms
  LEP16, SPRL6A, SPRL6B
• Links
  HGNC:16615

  NCBI Gene ID: 84648

  neXtProt AC: NX_Q9BYE3

  UniProt: Q9BYE3

  
  
• Chr Location
  1q21.3; chr1:152579381-152580516 (-)  GRCh38

---

• Human Ortholog
  LCE3E, late cornified envelope 3E
  
• Synonyms
  LEP17
• Links
  HGNC:29463

  NCBI Gene ID: 353145

  neXtProt AC: NX_Q5T5B0

  UniProt: Q5T5B0

  
  
• Chr Location
  1q21.3; chr1:152565654-152566780 (-)  GRCh38

---

• MGI Vertebrate Homology
  Lce3b stringent orthology
  4 human;1 mouse;1 rat
  
• HCOP
  vertebrate homology predictions: LCE3B, LCE3C, LCE3D, LCE3E
• Gene Tree
  Lce3b
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  8 phenotype references
  

• All Mutations and Alleles
  6
• Chemically induced (other)
  1
• Endonuclease-mediated
  2
• Radiation induced
  1
• Targeted
  2
• Genomic Mutations
  2 involving Lce3b
• Find Mice (IMSR)
  6 strains or lines available

Expression

• Assay Results
  706
• cDNA Data
  5
• Literature Summary
  3

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  31
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS38520.1

• Ensembl
  ENSMUSG00000042031 (Evidence)
• NCBI Gene
  66344

Representative Sequences			Length	Strain/Species
genomic	66344	NCBI Gene Model | MGI Sequence Detail	1119	C57BL/6J
transcript	NM_025501	RefSeq | MGI Sequence Detail	562	C57BL/6
polypeptide	NP_079777	RefSeq | MGI Sequence Detail	98	C57BL/6

Protein
Information

• UniProt
  1 Sequence
• InterPro Domains
  IPR028205 Late cornified envelope protein

Molecular
Reagents

• All nucleic 5

  cDNA 5

  
  

  Microarray probesets 3

References

• Summaries
  All 25

  Developmental Gene Expression 3

  Diseases 1

  Phenotypes 8
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426

TSS for Lce3b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30313	Chr3:92840282-92840290 (+)	0 bp