Gmpr MGI Mouse Gene Detail - MGI:1913605 - guanosine monophosphate reductase

Symbol

Gmpr
Name

guanosine monophosphate reductase
Synonyms

2310004P21Rik

Feature Type

protein coding gene
IDs

MGI:1913605
NCBI Gene: 66355
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr13:45660905-45699862 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 21.94 cM
Mapping Data

2 experiments

SNPs within 2kb

1207 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913605	protein coding gene	Chr13:45660905-45707276 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020508	protein coding gene	Chr13:44221597-44268158 (+)
A/J	MGP_AJ_G0020462	protein coding gene	Chr13:42681912-42721349 (+)
AKR/J	MGP_AKRJ_G0020439	protein coding gene	Chr13:43869925-43908551 (+)
BALB/cJ	MGP_BALBcJ_G0020458	protein coding gene	Chr13:42890649-42929853 (+)
C3H/HeJ	MGP_C3HHeJ_G0020257	protein coding gene	Chr13:43707396-43747856 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020891	protein coding gene	Chr13:45567674-45607325 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018478	protein coding gene	Chr13:40755350-40794650 (+)
CAST/EiJ	MGP_CASTEiJ_G0019772	protein coding gene	Chr13:43645192-43684347 (+)
CBA/J	MGP_CBAJ_G0020218	protein coding gene	Chr13:47457953-47504715 (+)
DBA/2J	MGP_DBA2J_G0020340	protein coding gene	Chr13:42252592-42291423 (+)
FVB/NJ	MGP_FVBNJ_G0020319	protein coding gene	Chr13:41770978-41810387 (+)
LP/J	MGP_LPJ_G0020415	protein coding gene	Chr13:44443592-44482817 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020348	protein coding gene	Chr13:47323186-47362392 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020934	protein coding gene	Chr13:43542589-43582700 (+)
PWK/PhJ	MGP_PWKPhJ_G0019528	protein coding gene	Chr13:42367687-42407637 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019356	protein coding gene	Chr13:42212692-42252862 (+)
WSB/EiJ	MGP_WSBEiJ_G0019834	protein coding gene	Chr13:43858069-43898140 (+)

Human Ortholog

GMPR, guanosine monophosphate reductase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GMPR, guanosine monophosphate reductase
Synonyms

GMPR 1, GMPR1
Links

HGNC:4376

NCBI Gene ID: 2766

neXtProt AC: NX_P36959

UniProt: P36959
Chr Location

6p22.3; chr6:16238587-16295549 (+) GRCh38

MGI Vertebrate Homology

Gmpr stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GMPR
Protein SuperFamily

GMP_reductase
Gene Tree

Gmpr

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

5
Genomic Mutations

1 involving Gmpr
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

5
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

829
Tissues

97
cDNA Data

66
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gmpr

ZFIN gmpr

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All Sequences

59
RefSeq

8
UniProt

2
CCDS

CCDS26482.1

Ensembl

ENSMUSG00000000253 (Evidence)
NCBI Gene

66355

			Length	Strain/Species	Flank
genomic	66355	NCBI Gene Model \| MGI Sequence Detail	38958	C57BL/6J	± kb
transcript	NM_025508	RefSeq \| MGI Sequence Detail	1584	C57BL/6
polypeptide	Q9DCZ1	UniProt \| EBI \| MGI Sequence Detail	345	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008077 GMP reductase 1

(term hierarchy)
EC

1.7.1.7
InterPro Domains

IPR013785 Aldolase-type TIM barrel

IPR005993 GMP reductase

IPR050139 Guanosine monophosphate reductase

IPR001093 IMP dehydrogenase/GMP reductase

IPR015875 IMP dehydrogenase / GMP reductase, conserved site
GlyGen

Q9DCZ1 1 site, 1 O-linked glycan (1 site)

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All nucleic 67

cDNA 66

Other 1

Microarray probesets 3

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MGI:2145389

Summaries

All 36

Developmental Gene Expression 4

Gene Ontology 4

Phenotypes 10
Earliest

J:306715 Mager J, et al., Guanosine 5'-phosphate reductase and its role in the interconversion of purine nucleotides. J Biol Chem. 1960 May;235:1474-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gmpr:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119576	Chr13:45660914-45660991 (+)	48 bp
Tssr119577	Chr13:45661003-45661025 (+)	109 bp
Tssr119578	Chr13:45661040-45661052 (+)	141 bp
Tssr119579	Chr13:45661074-45661126 (+)	195 bp
Tssr119580	Chr13:45670455-45670501 (+)	9,573 bp
Tssr119581	Chr13:45692282-45692315 (+)	31,394 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24