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Ergic3 Gene Detail
Summary
  • Symbol
    Ergic3
  • Name
    ERGIC and golgi 3
  • Synonyms
    2310015B14Rik, CGI-54, D2Ucla1, NY-BR-84, Sdbcag84
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913616
    NCBI Gene: 66366
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:155849965-155860199 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 77.32 cM, cytoband H2
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    390 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913616
 protein coding gene Chr2:155849948-155860199 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026752
 protein coding gene Chr2:160865819-160875930 (+)
A/J MGP_AJ_G0026718
 protein coding gene Chr2:154477963-154488247 (+)
AKR/J MGP_AKRJ_G0026689
 protein coding gene Chr2:158960086-158970319 (+)
BALB/cJ MGP_BALBcJ_G0026727
 protein coding gene Chr2:154774397-154784508 (+)
C3H/HeJ MGP_C3HHeJ_G0026470
 protein coding gene Chr2:159325432-159335543 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027176
 protein coding gene Chr2:165591728-165602000 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024546
 protein coding gene Chr2:147972725-147983184 (+)
CAST/EiJ MGP_CASTEiJ_G0025931
 protein coding gene Chr2:159647606-159657802 (+)
CBA/J MGP_CBAJ_G0026447
 protein coding gene Chr2:171597966-171608077 (+)
DBA/2J MGP_DBA2J_G0026584
 protein coding gene Chr2:153651241-153661471 (+)
FVB/NJ MGP_FVBNJ_G0026551
 protein coding gene Chr2:152031171-152041282 (+)
LP/J MGP_LPJ_G0026689
 protein coding gene Chr2:161007185-161017296 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026572
 protein coding gene Chr2:175565366-175575477 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027232
 protein coding gene Chr2:158843096-158853207 (+)
PWK/PhJ MGP_PWKPhJ_G0025665
 protein coding gene Chr2:153155029-153165493 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025468
 protein coding gene Chr2:157786453-157797953 (+)
WSB/EiJ MGP_WSBEiJ_G0026001
 protein coding gene Chr2:159727249-159737358 (+)



Homology
more
  • Human Ortholog
    ERGIC3, ERGIC and golgi 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ERGIC3, ERGIC and golgi 3
  • Synonyms
    C20orf47, C2orf47, CGI-54, dJ477O4.2, Erv46, NY-BR-84, PRO0989, SDBCAG84
  • Links
    NCBI Gene ID: 51614
    neXtProt AC: NX_Q9Y282
    UniProt: Q9Y282

  • Chr Location
    20q11.22; chr20:35542038-35557634 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Knockout mice exhibit enlarged heart ventricles and decreased heart ventricular contractility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    4
  • cDNA Data
    147
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005881 Ensembl Gene Model | MGI Sequence Detail 10235 C57BL/6J ±  kb
    transcript ENSMUST00000088650 Ensembl | MGI Sequence Detail 1349 Not Applicable  
    polypeptide ENSMUSP00000086025 Ensembl | MGI Sequence Detail 394 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000007176 endoplasmic reticulum-Golgi intermediate compartment protein 3
      (term hierarchy)
    • InterPro Domains
      IPR045888 Endoplasmic reticulum vesicle transporter
      IPR012936 Endoplasmic reticulum vesicle transporter, C-terminal
      IPR039542 Endoplasmic reticulum vesicle transporter, N-terminal
    • GlyGen
      Q9CQE7 3 sites, 5 N-linked glycans (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 149
      cDNA 147
      Primer pair 1
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-6181, MGI:2139267, MGI:92308
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 6
    • Earliest
      J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
    • Latest
      J:345070 Guan L, et al., ERGIC2 and ERGIC3 regulate the ER-to-Golgi transport of gap junction proteins in metazoans. Traffic. 2022 Mar;23(3):140-157
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory