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Tsfm Gene Detail
Summary
  • Symbol
    Tsfm
  • Name
    Ts translation elongation factor, mitochondrial
  • Synonyms
    2310050B20Rik, 9430024O13Rik, EF-TS, EF-Tsmt
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913649
    NCBI Gene: 66399
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:126858201-126866683 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 74.50 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    406 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913649
 protein coding gene Chr10:126847441-126866709 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017799
 protein coding gene Chr10:130583193-130605347 (-)
A/J MGP_AJ_G0017774
 protein coding gene Chr10:125355626-125374866 (-)
AKR/J MGP_AKRJ_G0017737
 protein coding gene Chr10:129066496-129085715 (-)
BALB/cJ MGP_BALBcJ_G0017738
 protein coding gene Chr10:125762896-125782187 (-)
C3H/HeJ MGP_C3HHeJ_G0017562
 protein coding gene Chr10:129196964-129218376 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018193
 protein coding gene Chr10:135010044-135034325 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015873
 protein coding gene Chr10:119379326-119398422 (-)
CAST/EiJ MGP_CASTEiJ_G0017122
 protein coding gene Chr10:129849872-129869814 (-)
CBA/J MGP_CBAJ_G0017531
 protein coding gene Chr10:140427740-140448302 (-)
DBA/2J MGP_DBA2J_G0017637
 protein coding gene Chr10:124442782-124462600 (-)
FVB/NJ MGP_FVBNJ_G0017632
 protein coding gene Chr10:123392944-123414002 (-)
LP/J MGP_LPJ_G0017711
 protein coding gene Chr10:131154835-131174111 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017660
 protein coding gene Chr10:143168028-143188802 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018233
 protein coding gene Chr10:129122224-129142722 (-)
PWK/PhJ MGP_PWKPhJ_G0016907
 protein coding gene Chr10:124632199-124652112 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016699
 protein coding gene Chr10:128146222-128166760 (-)
WSB/EiJ MGP_WSBEiJ_G0017183
 protein coding gene Chr10:129343264-129366323 (-)



Homology
more
  • Human Ortholog
    TSFM, Ts translation elongation factor, mitochondrial
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSFM, Ts translation elongation factor, mitochondrial
  • Synonyms
    EFTS, EFTSMT
  • Links
    NCBI Gene ID: 10102
    neXtProt AC: NX_P43897
    UniProt: P43897

  • Chr Location
    12q14.1; chr12:57782761-57808071 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TSFM associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    47
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66399 NCBI Gene Model | MGI Sequence Detail 8483 C57BL/6J ±  kb
    transcript NM_025537 RefSeq | MGI Sequence Detail 1180 C57BL/6  
    polypeptide Q9CZR8 UniProt | EBI | MGI Sequence Detail 324 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000016718 elongation factor Ts, mitochondrial
      (term hierarchy)
    • InterPro Domains
      IPR036402 Elongation factor Ts, dimerisation domain superfamily
      IPR001816 Translation elongation factor EFTs/EF1B
      IPR014039 Translation elongation factor EFTs/EF1B, dimerisation
      IPR018101 Translation elongation factor Ts, conserved site
      IPR009060 UBA-like superfamily
    • GlyGen
      Q9CZR8 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 47

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1924571
    References
    more
    • Summaries
      All 37
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:350560 Tomar A, et al., Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs. Nature. 2024 Jun;630(8017):720-727
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory