Rtf2 MGI Mouse Gene Detail - MGI:1913654 - replication termination factor 2

Symbol

Rtf2
Name

replication termination factor 2
Synonyms

1700067C04Rik, 2410001C21Rik, 5730427M17Rik, Rtfdc1

Feature Type

protein coding gene
IDs

MGI:1913654
NCBI Gene: 66404
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:172282498-172311819 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 94.86 cM, cytoband H3
Mapping Data

3 experiments

SNPs within 2kb

1002 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913654	protein coding gene	Chr2:172282476-172311828 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026945	protein coding gene	Chr2:178612910-178642654 (+)
A/J	MGP_AJ_G0026912	protein coding gene	Chr2:171135506-171165492 (+)
AKR/J	MGP_AKRJ_G0026883	protein coding gene	Chr2:176303832-176335161 (+)
BALB/cJ	MGP_BALBcJ_G0026921	protein coding gene	Chr2:171526608-171563314 (+)
C3H/HeJ	MGP_C3HHeJ_G0026663	protein coding gene	Chr2:176654673-176685598 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027368	protein coding gene	Chr2:183780216-183811201 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024738	protein coding gene	Chr2:164383741-164414645 (+)
CAST/EiJ	MGP_CASTEiJ_G0026121	protein coding gene	Chr2:177325350-177356247 (+)
CBA/J	MGP_CBAJ_G0026640	protein coding gene	Chr2:190638901-190668222 (+)
DBA/2J	MGP_DBA2J_G0026778	protein coding gene	Chr2:170230188-170259514 (+)
FVB/NJ	MGP_FVBNJ_G0026744	protein coding gene	Chr2:168831890-168861842 (+)
LP/J	MGP_LPJ_G0026879	protein coding gene	Chr2:178544859-178575528 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026763	protein coding gene	Chr2:193627849-193662202 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027425	protein coding gene	Chr2:176272009-176302296 (+)
PWK/PhJ	MGP_PWKPhJ_G0025858	protein coding gene	Chr2:169989597-170027331 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025658	protein coding gene	Chr2:175270178-175300887 (+)
WSB/EiJ	MGP_WSBEiJ_G0026194	protein coding gene	Chr2:177245407-177274759 (+)

Human Ortholog

RTF2, replication termination factor 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RTF2, replication termination factor 2
Synonyms

C20orf43, CDAO5, HSPC164, RTFDC1, SHUJUN-3
Links

HGNC:15890

NCBI Gene ID: 51507

neXtProt AC: NX_Q9BY42

UniProt: Q9BY42
Chr Location

20q13.31; chr20:56468585-56519449 (+) GRCh38

MGI Vertebrate Homology

Rtf2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RTF2
Gene Tree

Rtf2

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Phenotype Summary

4 phenotypes from 3 alleles in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Gene trapped

10
Targeted

5
Incidental Mutations

APF
Find Mice (IMSR)

17 strains or lines available

Mice homozygous for a null allele display embryonic lethality. Null MEFs display decreased DNA replication and slowed proliferation.

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

159
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rtf2

ZFIN rtf2

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All Sequences

55
RefSeq

2
UniProt

6
CCDS

CCDS17132.1

Ensembl

ENSMUSG00000027502 (Evidence)
NCBI Gene

66404

			Length	Strain/Species	Flank
genomic	66404	NCBI Gene Model \| MGI Sequence Detail	29322	C57BL/6J	± kb
transcript	NM_025542	RefSeq \| MGI Sequence Detail	2142	C57BL/6
polypeptide	Q99K95	UniProt \| EBI \| MGI Sequence Detail	307	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000060058 replication termination factor 2

(term hierarchy)
InterPro Domains

IPR006735 Replication termination factor 2

IPR027799 Replication termination factor 2, RING-finger

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All nucleic 160

cDNA 160

Microarray probesets 3

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MGI:1921524, MGI:2138797, MGI:6107623

Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:360903 Conti BA, et al., RTF2 controls replication repriming and ribonucleotide excision at the replisome. Nat Commun. 2024 Mar 2;15(1):1943

TSS for Rtf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21953	Chr2:172282485-172282550 (+)	20 bp
Tssr21954	Chr2:172282570-172282577 (+)	76 bp
Tssr21955	Chr2:172284110-172284117 (+)	1,616 bp
Tssr21956	Chr2:172297409-172297416 (+)	14,915 bp
Tssr21957	Chr2:172303284-172303314 (+)	20,801 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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