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Fis1 Gene Detail
Summary
  • Symbol
    Fis1
  • Name
    fission, mitochondrial 1
  • Synonyms
    2010003O14Rik, Ttc11
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913687
    NCBI Gene: 66437
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:136982129-136995088 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 76.06 cM, cytoband G1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    468 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913687
 protein coding gene Chr5:136982129-136995088 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030210
 protein coding gene Chr5:141654822-141668023 (+)
A/J MGP_AJ_G0030178
 protein coding gene Chr5:135523410-135537041 (+)
AKR/J MGP_AKRJ_G0030111
 protein coding gene Chr5:139916155-139928883 (+)
BALB/cJ MGP_BALBcJ_G0030188
 protein coding gene Chr5:136885428-136898169 (+)
C3H/HeJ MGP_C3HHeJ_G0029904
 protein coding gene Chr5:140536881-140549618 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030640
 protein coding gene Chr5:146932015-146947003 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027861
 protein coding gene Chr5:129808638-129813158 (+)
CAST/EiJ MGP_CASTEiJ_G0029314
 protein coding gene Chr5:139951834-139965838 (+)
CBA/J MGP_CBAJ_G0029874
 protein coding gene Chr5:152659827-152675691 (+)
DBA/2J MGP_DBA2J_G0030025
 protein coding gene Chr5:135419244-135431979 (+)
FVB/NJ MGP_FVBNJ_G0029980
 protein coding gene Chr5:134597061-134610205 (+)
LP/J MGP_LPJ_G0030114
 protein coding gene Chr5:142093381-142107935 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030012
 protein coding gene Chr5:155570015-155583447 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030681
 protein coding gene Chr5:139741153-139753875 (+)
PWK/PhJ MGP_PWKPhJ_G0029027
 protein coding gene Chr5:134507236-134520254 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028863
 protein coding gene Chr5:137332476-137345859 (+)
WSB/EiJ MGP_WSBEiJ_G0029387
 protein coding gene Chr5:140484620-140500443 (+)



Homology
more
  • Human Ortholog
    FIS1, fission, mitochondrial 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FIS1, fission, mitochondrial 1
  • Synonyms
    CGI-135, TTC11
  • Links
    NCBI Gene ID: 51024
    neXtProt AC: NX_Q9Y3D6
    UniProt: Q9Y3D6

  • Chr Location
    7q22.1; chr7:101239458-101252316 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in skeletal muscle exhibit impaired exercise endurance with abnormal mitochondria. Mice homozygous for another conditional allele activated in male germ cells exhibit abnormal mitochondrial morphology and arrested spermatid maturation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    2
  • cDNA Data
    136
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66437 NCBI Gene Model | MGI Sequence Detail 12960 C57BL/6J ±  kb
    transcript NM_001163243 RefSeq | MGI Sequence Detail 966 C57BL/6  
    polypeptide Q9CQ92 UniProt | EBI | MGI Sequence Detail 152 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000007527 mitochondrial fission 1 protein
      (term hierarchy)
    • PDB
      1IYG
    • InterPro Domains
      IPR028061 Fis1, C-terminal tetratricopeptide repeat
      IPR028058 Fis1, N-terminal tetratricopeptide repeat
      IPR016543 Mitochondria fission 1 protein
      IPR033745 Mitochondria fission protein Fis1, cytosolic domain
      IPR011990 Tetratricopeptide-like helical domain superfamily
    • GlyGen
      Q9CQ92 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 137
      cDNA 136
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 7
      Gene Ontology 13
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:347601 Shen T, et al., Cardiac-specific deletion of heat shock protein 60 induces mitochondrial stress and disrupts heart development in mice. Biochem Biophys Res Commun. 2024 May 28;710:149883
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory